2022
DOI: 10.1016/j.molstruc.2021.132052
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Mechanochemical synthesis and characterization of a novel AAs–Flucytosine drug–drug cocrystal: A versatile model system for green approaches

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Cited by 9 publications
(5 citation statements)
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“…Raman spectra of all SE powders have comparable peak positions to DAP and PEG ( Figure 6 I), whereby only some minor peak shifts can be observed, indicating the successful formation of co-crystals ( Table 8 ). Moreover, it is difficult to say, based on the spectra, if there are any pure single components left over in SE powders as large spectra changes might not be expected even if there are changes in intermolecular interactions (transformation from single components to co-crystals) [ 46 ]. However, the spectrum of SECC1500B does not show the same Raman pattern as the other SECCs ( Figure 6 ), as a peak at 1020 cm −1 is shown that does not represent the presence of DAP form III or PEGs or DAP-PEG co-crystals.…”
Section: Resultsmentioning
confidence: 99%
“…Raman spectra of all SE powders have comparable peak positions to DAP and PEG ( Figure 6 I), whereby only some minor peak shifts can be observed, indicating the successful formation of co-crystals ( Table 8 ). Moreover, it is difficult to say, based on the spectra, if there are any pure single components left over in SE powders as large spectra changes might not be expected even if there are changes in intermolecular interactions (transformation from single components to co-crystals) [ 46 ]. However, the spectrum of SECC1500B does not show the same Raman pattern as the other SECCs ( Figure 6 ), as a peak at 1020 cm −1 is shown that does not represent the presence of DAP form III or PEGs or DAP-PEG co-crystals.…”
Section: Resultsmentioning
confidence: 99%
“…Cocrystallization has been considered an effective method to alter the physicochemical properties of active ingredients in pharmaceutical drugs. The cocrystals can be created through various processes, including grinding (neat or dry and solvent-assisted grinding), slurry conversion, antisolvent addition, and solvent evaporation [14,15]. Obtaining good structure and quality of cocrystal particles required developing new or/and a combination of various fabrication methods.…”
Section: Cocrystal Engineeringmentioning
confidence: 99%
“…Kokristals piracetam dengan asam sitrat dan asam tartrat diperoleh melalui teknik ini [26]. Grinding dan milling merupakan teknik yang berbeda, karena grinding adalah prosedur mekanokimia yang bekerja dalam mortal dan milling dilakukan dalam perangkat ball mills [27]. Ball milling digunakan ketika diperlukan input energy lebih tinggi, waktu yang lebih sistematis diperlukan untuk reaksi dan pencampuran yang lebih baik di laboratorium.…”
Section: Gambar 2 Metode Mekanokimia Pada Pembuatan Kokristal Farmasiunclassified