Mechanochemical synthesis, characterization and thermoanalytical study of a new curcumin derivative

Moura, Aniele de; Gaglieri, Caroline; Silva‐Filho, Luiz Carlos da; Caires, Flávio Júnior

doi:10.1007/s10973-020-10000-w

Cited by 5 publications

(19 citation statements)

References 32 publications

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“…As shown in Figure 3 Both epinephrine and collagen are potent platelet activators and cause significan platelet aggregation, and epinephrine has a significant vasoconstrictive effect [39]. A pre In addition, for Cur, a sharp endothermic peak was observed at 186 • C, which is the melting point of pure Cur [36]. In Physical mixture 2, there were endothermic peaks at 59 • C and 186 • C and an exothermic peak at 254 • C. In contrast, no endothermic (melting) peak of Cur was observed in the DSC thermogram of DG1/Cur-NPs.…”

Section: Dsc Analysismentioning

confidence: 99%

Chitosan/Alginate Nanoparticles for the Enhanced Oral Antithrombotic Activity of Clam Heparinoid from the Clam Coelomactra antiquata

et al. 2022

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Chitosan/alginate nanoparticles (DG1-NPs and DG1/Cur-NPs) aiming to enhance the oral antithrombotic activity of clam heparinoid DG1 were prepared by ionotropic pre-gelation. The influence of parameters, such as the concentration of sodium alginate (SA), chitosan (CTS), CaCl2, clam heparinoid DG1, and curcumin (Cur), on the characteristics of the nanoparticles, were investigated. Results indicate that chitosan and alginate can be used as polymer matrices to encapsulate DG1, and nanoparticle characteristics depend on the preparation parameters. Nano-particles should be prepared using 0.6 mg/mL SA, 0.33 mg/mL CaCl2, 0.6 mg/mL CTS, 7.2 mg/mL DG1, and 0.24 mg/mL Cur under vigorous stirring to produce DG1-NPS and DG1/Cur-NPS with small size, high encapsulation efficiency, high loading capacity, and negative zeta potential from approximately −20 to 30 mV. Data from scanning electron microscopy, Fourier-transform infrared spectrometry, and differential scanning calorimetry analyses showed no chemical reaction between DG1, Cur, and the polymers; only physical mixing. Moreover, the drug was loaded in the amorphous phase within the nanoparticle matrix. In the acute pulmonary embolism murine model, DG1-NPs enhanced the oral antithrombotic activity of DG1, but DG1/Cur-NPs did not exhibit higher antithrombotic activity than DG1-NPs. Therefore, the chitosan/alginate nanoparticles enhanced the oral antithrombotic activity of DG1, but curcumin did not further enhance this effect.

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Section: Dsc Analysismentioning

confidence: 99%

Chitosan/Alginate Nanoparticles for the Enhanced Oral Antithrombotic Activity of Clam Heparinoid from the Clam Coelomactra antiquata

et al. 2022

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“…Moreover, some authors suggest that the band at 1603 cm À 1 is associated with aromatic C=C stretching overlapped with C=O absorption. [5,51] The C=C stretching of aromatic ring appears as two bands at 1509 cm À 1 and 1429 cm À 1 .…”

Section: Mirmentioning

confidence: 99%

“…The curcumin (CUR) is the major component present in Curcuma longa turmeric rhizomes; other curcuminoids are also present, such as demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), however, in a minor concentration. [1][2][3][4][5] Curcuma longa is one of the most extensively studied plants, due to its wide-ranging pharmacological activities safety. Curcumin is a hydrophobic phenol, which displays a variety of pharmacological effects, among them, anticancer, anti-inflammatory, anti-HIV agent, and antioxidant biological activities.…”

Section: Introductionmentioning

confidence: 99%

“…Curcumin is a hydrophobic phenol, which displays a variety of pharmacological effects, among them, anticancer, anti-inflammatory, anti-HIV agent, and antioxidant biological activities. [1][2][3][4][5] In addition, curcumin presents low cytotoxicity, even at a high dose of 12 g per day in animal and human experiments, although it has poor absorption and consequently low bioavailability, due to its low solubility in water. [1][2][3][4][5][6] Then, the development of curcumin derivatives has been widespread, aiming to increase its biological properties or improve its solubility.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] In addition, curcumin presents low cytotoxicity, even at a high dose of 12 g per day in animal and human experiments, although it has poor absorption and consequently low bioavailability, due to its low solubility in water. [1][2][3][4][5][6] Then, the development of curcumin derivatives has been widespread, aiming to increase its biological properties or improve its solubility. [1][2][3] Another compound, which plays a role in biological studies, is the coumarins, which is found in Cumaru seeds, its wide range of biological properties can be mainly related to the anticoagulant, antioxidant, antimicrobial, anti-inflammatory, and antitumor activities.…”

Section: Introductionmentioning

confidence: 99%

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A New Curcuminoids‐Coumarin Derivative: Mechanochemical Synthesis, Characterization and Evaluation of Its In Vitro Cytotoxicity and Antimicrobial Properties

et al. 2021

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Over the years, several drugs have been developed deriving from plants to investigate possible therapeutic roles. Among them, curcuminoids and coumarins, which, display a wide range of biological activity against several strains. Therefore, it was synthesized a curcuminoids-coumarin derivative by a mechanochemical multicomponent reaction. By NMR and HRMS results confirmed the formation of a mixture of three curcuminoids-coumarin derivatives in the same sample. The Influence of time during the milling process was evaluated, resulting in a crystalline product in only 30 min. The LAG milling carried out with different solvents showed that the product is obtained regardless of the solvent polarity. Furthermore, the biological evaluation showed that the curcuminoidscoumarin derivative has better activity against S. aureus than curcumin and 4-hydroxycoumarin. Lastly, the cell viability study exhibited a decrease of cytotoxicity of the derivative, compared to curcumin, against NIH3T3 cells.

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Green synthesis of a Schiff base ligand and its Co(II), Cu(II) and Zn(II) complexes: thermoanalytical and spectroscopic studies

Moura

Júnior

Carvalho

et al. 2022

J Therm Anal Calorim

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Mechanochemical synthesis, characterization and thermoanalytical study of a new curcumin derivative

Cited by 5 publications

References 32 publications

Chitosan/Alginate Nanoparticles for the Enhanced Oral Antithrombotic Activity of Clam Heparinoid from the Clam Coelomactra antiquata

Chitosan/Alginate Nanoparticles for the Enhanced Oral Antithrombotic Activity of Clam Heparinoid from the Clam Coelomactra antiquata

A New Curcuminoids‐Coumarin Derivative: Mechanochemical Synthesis, Characterization and Evaluation of Its In Vitro Cytotoxicity and Antimicrobial Properties

Green synthesis of a Schiff base ligand and its Co(II), Cu(II) and Zn(II) complexes: thermoanalytical and spectroscopic studies

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