Mechanochemistry of ibuprofen pharmaceutical

Andini, Salvatore; Bolognese, Adele; Formisano, Domenico; Manfra, Michele; Montagnaro, Fabio; Santoro, L.

doi:10.1016/j.chemosphere.2012.03.025

Cited by 37 publications

(32 citation statements)

References 41 publications

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“…Ball milling can also be used to degrade chemical species. Mechanochemical degradation has been used to treat wastes such as aromatic compounds, halogenated compounds and pharmaceuticals [18-24]. Unlike traditional degradation methods which use oxidizing agents, milling utilizes the mechanical energy to activate chemical reactions, suggesting possible merit as an eco-friendly process [25].…”

Section: Introductionmentioning

confidence: 99%

Preparation of ultrafine magnetic biochar and activated carbon for pharmaceutical adsorption and subsequent degradation by ball milling

Shan

Deng

Zhao

et al. 2016

Journal of Hazardous Materials

357

118

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Ball milling was used to prepare two ultrafine magnetic biochar/Fe3O4 and activated carbon (AC)/Fe3O4 hybrid materials targeted for use in pharmaceutical removal by adsorption and mechanochemical degradation of pharmaceutical compounds. Both hybrid adsorbents prepared after 2 hours milling exhibited high removal of carbamazepine (CBZ), and were easily separated magnetically. These adsorbents exhibited fast adsorption of CBZ and tetracycline (TC) in the initial 1 hour. The biochar/Fe3O4 had a maximum adsorption capacity of 62.7 mg/g for CBZ and 94.2 mg/g for TC, while values obtained for AC/Fe3O4 were 135.1 mg/g for CBZ and 45.3 mg/g for TC respectively when data were fitted using the Langmuir expression. Solution pH values slightly affected the sorption of TC on the adsorbents, while CBZ sorption was almost pH-independent. The spent adsorbents with adsorbed CBZ and TC were milled to degrade the adsorbed pollutants. The adsorbed TC itself was over 97% degraded after 3 hours of milling, while about half of adsorbed CBZ were remained. The addition of quartz sand was found to improve the mechanochemical degradation of CBZ on biochar/Fe3O4, and its degradation percent was up to 98.4% at the dose of 0.3 g quarts sand/g adsorbent. This research provided an easy method to prepare ultrafine magnetic adsorbents for the effective removal of typical pharmaceuticals from water or wastewater and degrade them using ball milling.

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Section: Introductionmentioning

confidence: 99%

Preparation of ultrafine magnetic biochar and activated carbon for pharmaceutical adsorption and subsequent degradation by ball milling

Shan

Deng

Zhao

et al. 2016

Journal of Hazardous Materials

357

118

View full text Add to dashboard Cite

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“…Another one tends to tribochemistry via organic mechanochemistry [76]. The same is due to review papers [13,[16][17] and book chapters [48][49][50].…”

Section: Selected Books and Review Publicationsmentioning

confidence: 99%

“…Thereafter, mechanochemical treatments are environmentally sound for general approach to detoxify chemical-pharmaceutical waste. Thus, in this case a type of molecular mechanolysis without solvent or usual thermal contribution can be considered [76].…”

Section: Practical Aspects Of Mechanochemistrymentioning

confidence: 99%

“…Another study [76] demonstrates that the mechanochemical treatment of an expired drug as ibufren, may be very useful and non-polluting way to change the bioactive molecule of a pharmaceutical formulation into non-toxic product. In the degradation mechanism two major steps are considered.…”

Section: Practical Aspects Of Mechanochemistrymentioning

confidence: 99%

“…The term mechanochemistry was coined by Oswald for the corresponding branch of chemical physics. In this sense, mechanochemistry should be considered along with thermochemistry, electrochemistry, photochemistry, sonochemistry, chemistry of high pressures, shock waves, or microwave effects [76]. In fact, organic solids are very liable to attrition; inorganic materials appear to be more resistant [81] and the attrition represents wear caused by rubbing or friction which already relates to tribochemistry.…”

Section: Mechanochemistry Vs Tribochemistrymentioning

confidence: 99%

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General Approach to Mechanochemistry and Its Relation to Tribochemistry

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Opportunities and Challenges in Applying Solid‐State NMR Spectroscopy in Organic Mechanochemistry

et al. 2023

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In recent years it was shown that mechanochemical strategies can be beneficial in directed conversions of organic compounds. Finding new reactions proved difficult, and due to the lack of mechanistic understanding of mechanochemical reaction events, respective efforts have mostly remained empirical. Spectroscopic techniques are crucial in shedding light on these questions. In this overview, the opportunities and challenges of solid‐state nuclear magnetic resonance (NMR) spectroscopy in the field of organic mechanochemistry are discussed. After a brief discussion of the basics of high‐resolution solid‐state NMR under magic‐angle spinning (MAS) conditions, seven opportunities for solid‐state NMR in the field of organic mechanochemistry are presented, ranging from ex‐situ approaches to structurally elucidate reaction products obtained by milling to the potential and limitations of in‐situ solid‐state NMR approaches. Particular strengths of solid‐state NMR, for instance in differentiating polymorphs, in NMR‐crystallographic structure‐determination protocols, or in detecting weak noncovalent interactions in molecular‐recognition events employing proton‐detected solid‐state NMR experiments at fast MAS frequencies, are discussed.This article is protected by copyright. All rights reserved

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Mechanochemistry of ibuprofen pharmaceutical

Cited by 37 publications

References 41 publications

Preparation of ultrafine magnetic biochar and activated carbon for pharmaceutical adsorption and subsequent degradation by ball milling

Preparation of ultrafine magnetic biochar and activated carbon for pharmaceutical adsorption and subsequent degradation by ball milling

General Approach to Mechanochemistry and Its Relation to Tribochemistry

Opportunities and Challenges in Applying Solid‐State NMR Spectroscopy in Organic Mechanochemistry

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