Mechanoreceptors and nerve endings of the triangular fibrocartilage in the human wrist

Cavalcante, Maria Luzete Costa; Rodrigues, Consuelo Junqueira; Mattar, Rames

doi:10.1016/j.jhsa.2004.01.001

Cited by 39 publications

(37 citation statements)

References 11 publications

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“…The articular disc had only free nerve endings in its ulnar portion. This is in contrast to Calvacante et al [2], who reported that the central area was noninnervated, but the periphery of the articular disc had all types of sensory nerve endings. The primary difference between our study and that of Calvacante et al [2] is that we mapped the mechanoreceptor population using a combination of immunohistochemical markers: S-100 protein, the neurotrophic receptor p75, and PGP 9.5.…”

Section: Interstructural Distribution and Mechanoreceptor Typescontrasting

confidence: 83%

“…This is in contrast to Calvacante et al [2], who reported that the central area was noninnervated, but the periphery of the articular disc had all types of sensory nerve endings. The primary difference between our study and that of Calvacante et al [2] is that we mapped the mechanoreceptor population using a combination of immunohistochemical markers: S-100 protein, the neurotrophic receptor p75, and PGP 9.5. These three antibodies allow precise differentiation of mechanoreceptors owing to selective delineation of specific neural and perineural structures in sensory nerve endings [22].…”

Section: Interstructural Distribution and Mechanoreceptor Typescontrasting

confidence: 83%

“…A previous histologic analysis of the triangular fibrocartilage, separated in five areas according to dorsal, palmar, ulnar, radial, or central position, showed that the central area is noninnervated, but the periphery of the triangular fibrocartilage has all types of sensory nerve endings [2]. However, a gold chloride technique was used, which impregnates not only nerve tissue, but also elastic fibers in blood vessels and reticular fibers, thus providing nonspecific imaging of neural elements in tissue [6,15,25].…”

Section: Introductionmentioning

confidence: 98%

“…Questions/purposes We aimed to (1) analyze the general distribution of sensory nerve endings and blood vessels; (2) examine interstructural distribution of sensory nerve endings and blood vessels; (3) compare the number and types of mechanoreceptors in each part; and (4) analyze intrastructural distribution of nerve endings at different tissue depth. Methods The subsheath of the extensor carpi ulnaris tendon sheath, the ulnocarpal meniscoid, the articular disc, the dorsal and volar radioulnar ligaments, and the ulnolunate and ulnotriquetral ligaments were dissected from 11 human cadaver wrists.…”

mentioning

confidence: 99%

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Immunohistochemical Mapping of Sensory Nerve Endings in the Human Triangular Fibrocartilage Complex

Rein

Semisch

García-Elias

et al. 2015

Clin Orthop Relat Res

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Background The triangular fibrocartilage complex is the main stabilizer of the distal radioulnar joint. While static joint stability is constituted by osseous and ligamentous integrity, the dynamic aspects of joint stability chiefly concern proprioceptive control of the compressive and directional muscular forces acting on the joint. Therefore, an investigation of the pattern and types of sensory nerve endings gives more insight in dynamic distal radioulnar joint stability.Questions/purposes We aimed to (1) analyze the general distribution of sensory nerve endings and blood vessels; (2) examine interstructural distribution of sensory nerve endings and blood vessels; (3) compare the number and types of mechanoreceptors in each part; and (4) analyze intrastructural distribution of nerve endings at different tissue depth. Methods The subsheath of the extensor carpi ulnaris tendon sheath, the ulnocarpal meniscoid, the articular disc, the dorsal and volar radioulnar ligaments, and the ulnolunate and ulnotriquetral ligaments were dissected from 11 human cadaver wrists. Sensory nerve endings were counted in five levels per specimen as total cell amount/ cm 2 after staining with low-affinity neurotrophin receptor p75, protein gene product 9.5, and S-100 protein and thereafter classified according to Freeman and Wyke. Results All types of sensory corpuscles were found in the various structures of the triangular fibrocartilage complex with the exception of the ulnolunate ligament, which contained only Golgi-like endings, free nerve endings, and unclassifiable corpuscles. The articular disc had only free nerve endings. Furthermore, free nerve endings were the predominant sensory nerve ending (median, 72.6/cm 2 ; range, 0-469.4/cm 2 ) and more prevalent than all other types of mechanoreceptors: Ruffini (median, 0; range, 0-5.6/cm 2 ; difference of medians, 72.6; p \ 0.001), Pacini (median, 0; range, 0-3.8/cm 2 ; difference of medians, 72.6; p \ 0.001), Golgi-like (median, 0; range, 0-2.1/cm 2 ; difference of medians, 72.6; p \ 0.001), and unclassifiable corpuscles (median, 0; range, 0-2.5/cm 2 ; difference of medians, 72.6; p \ 0.001). The articular disc contained fewer free nerve endings (median, 1.8; range, 0-17.8/cm 2 ) and fewer blood vessels (median, 29.8; range, 0-112.2/ cm 2 ; difference of medians: 255.9) than all other structures of the triangular fibrocartilage complex (p B 0.001, respectively) except the ulnolunate ligament. More blood vessels were seen in the volar radioulnar ligament (median, 363.62; range, 117.8-871.8/cm 2 ) compared with the ulnolunate ligament (median, 107.7; range, 15.9-410.3/cm 2 ; difference of medians: 255.91; p = 0.002) and the dorsal radioulnar ligament (median, 116.2; range, 53.9-185.1/ cm 2 ; difference of medians: 247.47; p = 0.001). Free nerve endings were obtained in each structure more often than all other types of sensory nerve endings (p \ 0.001, respectively). The intrastructural analysis revealed no differences in mechanoreceptor distribution in all investigat...

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Section: Interstructural Distribution and Mechanoreceptor Typescontrasting

confidence: 83%

Section: Interstructural Distribution and Mechanoreceptor Typescontrasting

confidence: 83%

Section: Introductionmentioning

confidence: 98%

mentioning

confidence: 99%

See 2 more Smart Citations

Immunohistochemical Mapping of Sensory Nerve Endings in the Human Triangular Fibrocartilage Complex

Rein

Semisch

García-Elias

et al. 2015

Clin Orthop Relat Res

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“…1 Histological examination of wrist joint structures including the triangular fibrocartilage complex and the intercarpal ligament has demonstrated the presence of various mechanoreceptors and sensory nerve endings. [2][3][4][5] Pain from nerve endings in the wrist joint is transmitted to the dorsal root ganglia (DRG) and spinal dorsal horn.…”

mentioning

confidence: 99%

Role of Low-Affinity Nerve Growth Factor Receptor Inhibitory Antibody in Reducing Pain Behavior and Calcitonin Gene-Related Peptide Expression in a Rat Model of Wrist Joint Inflammatory Pain

Iwakura

Ohtori

Orita

et al. 2010

The Journal of Hand Surgery

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Mechanoreceptors of the ligaments and tendons around the knee

Çabuk

2016

Clinical Anatomy

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Proprioceptive inputs from the joints and limbs arise from mechanoreceptors in the muscles, ligaments and tendons. The knee joint has a wide range of movements, and proper neuroanatomical organization is critical for knee stability. Four ligaments (the anterior (ACL) and posterior (PCL) cruciate ligaments and the medial (MCL) and lateral (LCL) collateral ligaments) and four tendons (the semitendinosus (STT), gracilis (GT), popliteal (PoT), and patellar (PaT) tendons) from eight fresh frozen cadavers were harvested. Each harvested tissue was divided into its bone insertion side and its tendinous part for immunohistochemical examination using S100 staining. Freeman-Wyke's classification was used to identify the mechanoreceptors. The mechanoreceptors were usually located close to the bone insertion. Free nerve endings followed by Ruffini endings were the most common mechanoreceptors overall. No Pacini corpuscles were observed; free nerve endings and Golgi-like endings were most frequent in the PCL (PCL-PaT: P = 0.0.1, PCL-STT: P = 0.00), and Ruffini endings in the popliteal tendon (PoT-PaT: P = 0.00, Pot-STT: P = 0.00, PoT-LCL: P = 0.00, PoT-GT: P = 0.00, PoT-ACL: P = 0.09). The cruciate ligaments had more mechanoreceptors than the medial structures (MS) or the patellar tendon (CR-Pat: P = 0.000, CR-MS: P = 0.01). The differences in mechanoreceptor distributions between the ligaments and tendons could reflect the different roles of these structures in the dynamic coordination of knee motion. Clin. Anat. 29:789-795, 2016. © 2016 Wiley Periodicals, Inc.

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Mechanoreceptors and nerve endings of the triangular fibrocartilage in the human wrist

Cited by 39 publications

References 11 publications

Immunohistochemical Mapping of Sensory Nerve Endings in the Human Triangular Fibrocartilage Complex

Immunohistochemical Mapping of Sensory Nerve Endings in the Human Triangular Fibrocartilage Complex

Role of Low-Affinity Nerve Growth Factor Receptor Inhibitory Antibody in Reducing Pain Behavior and Calcitonin Gene-Related Peptide Expression in a Rat Model of Wrist Joint Inflammatory Pain

Mechanoreceptors of the ligaments and tendons around the knee

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