Mechanoresponsive Drug Delivery Systems for Vascular Diseases

Navarro, Josep Fumadó; Lomora, Mihai

doi:10.1002/mabi.202200466

Cited by 2 publications

(1 citation statement)

References 194 publications

(449 reference statements)

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“…Mechanical force as an external/internal stimulus may induce breakage of the chemical bonds or cause structural destabilization for responsive drug delivery purposes. , Rifaie-Graham et al designed a block copolymer-based polymersome nanoreactor to study the permeabilization phenomenon. Under normal circumstances, nucleobases of its hydrophobic block remained in paired form, and the polymersome membrane stayed in an impermeable state.…”

Section: Permeability Tuningmentioning

confidence: 99%

Polymersome Membrane Engineering with Active Targeting or Controlled Permeability for Responsive Drug Delivery

Kayani,

Raza,

et al. 2023

Biomacromolecules

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Polymersomes have been extensively investigated for drug delivery as nanocarriers for two decades due to a series of advantages including high stability under physiological conditions, simultaneous encapsulation of hydrophilic and hydrophobic drugs inside inner cavities and membranes, respectively, and facile adjustment of membrane and surface properties, as well as controlled drug release through incorporation of stimuliresponsive components. Despite these features, polymersome nanocarriers frequently suffer from nontargeting delivery and poor membrane permeability. In recent years, polymersomes have been functionalized for more efficient drug delivery. The surface shells were explored to be modified with diverse active targeting groups to improve disease-targeting delivery. The membrane permeability of the polymersomes was adjusted by incorporation of the stimuliresponsive components for smart controlled transportation of the encapsulated drugs. Therefore, being the polymersome-biointerface, tailorable properties can be introduced by its carefully modulated engineering. This review elaborates on the role of polymersome membranes as a platform to incorporate versatile features. First, we discuss how surface functionalization facilitates the directional journey to the targeting sites toward specific diseases, cells, or intracellular organelles via active targeting. Moreover, recent advances in the past decade related to membrane permeability to control drug release are also summarized. We finally discuss future development to promote polymersomes as in vivo drug delivery nanocarriers.

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Section: Permeability Tuningmentioning

confidence: 99%

Polymersome Membrane Engineering with Active Targeting or Controlled Permeability for Responsive Drug Delivery

Kayani,

Raza,

et al. 2023

Biomacromolecules

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A New Class of Mechano‐Responsive Polyurethane Via Anthracene ‐TAD Diels‐Alder (DA) Click Chemistry

Chakraborty,

Choudhury,

Singha

2024

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Smart or stimuli‐responsive polymers have garnered significant interest in the scientific community due to their response to different stimuli like pH, temperature, light, mechanical force, etc. Mechanophoric polymer is an intriguing class of smart polymers that respond to external mechanical force by producing fluorescent moieties and can be utilized for damage detection and stress‐sensing assessment. In recent reports on mechanophoric polymers, different mechanophoric motifs such as spiropyran, rhodamine, coumarin, etc. are explored. This investigation reports a new kind of mechanophoric polyurethane (PU) adduct based on Diels‐Alder (DA) click chemistry. Here, an anthracene(An)‐end capped tri‐armed urethane system is synthesized, followed by a DA reaction using bis‐(1,2,4‐triazoline‐3,5‐dione) (bis‐TAD) derivative. The incorporation of bis‐TAD in the urethane system renders the anthracene inactive (“turn‐off”) by dismantling its conjugation as a result of a successful DA reaction. The soft PU translated into a harder material through bis‐TAD linkages between polymer chains as evident from nanoindentation (NINT) analysis. The resulting material reverts back to its fluorescent “turned‐on” mode owing to a force‐accelerated retro‐Diels‐Alder (r‐DA) reaction. Besides the mechanophoric attributes, the material demonstrates self‐healing behavior examined by microscopic investigations. This innovative approach can be a potential route to design responsive polymers with dynamic functionalities for advanced material applications.

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Mechanoresponsive Drug Delivery Systems for Vascular Diseases

Cited by 2 publications

References 194 publications

Polymersome Membrane Engineering with Active Targeting or Controlled Permeability for Responsive Drug Delivery

Polymersome Membrane Engineering with Active Targeting or Controlled Permeability for Responsive Drug Delivery

A New Class of Mechano‐Responsive Polyurethane Via Anthracene ‐TAD Diels‐Alder (DA) Click Chemistry

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