Mechanoresponsive Drug Release from a Flexible, Tissue‐Adherent, Hybrid Hydrogel Actuator

Mendez, Keegan; Whyte, William; Freedman, Benjamin R.; Rothenbucher, Sandra E; Fan, Yiling; Singh, Manisha; Cruz, Juan C.; Varela, Claudia E.; Li, Jianyu; Mooney, David J.; Roche, Ellen T.

doi:10.1002/adma.202303301

Cited by 22 publications

(1 citation statement)

References 44 publications

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“…These results emphasize the value of stimuli-responsive hydrogel-based robots as effective drug delivery systems, capable of delivering therapeutic agents to target sites while minimizing off-target effects which opens up new possibilities for personalized medicine and improved treatment strategies in cancer therapy. Mendez et al introduced a novel hybrid hydrogel actuator (HHA) [87]. The actuator can be securely adhered to tissue through a flexible, drug-permeable adhesive that can withstand the device's actuation.…”

Section: Drug Deliverymentioning

confidence: 99%

Biomedical Applications of Deformable Hydrogel Microrobots

Cao,

Chen,

Zhong

et al. 2023

Micromachines

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Hydrogel, a material with outstanding biocompatibility and shape deformation ability, has recently become a hot topic for researchers studying innovative functional materials due to the growth of new biomedicine. Due to their stimulus responsiveness to external environments, hydrogels have progressively evolved into “smart” responsive (such as to pH, light, electricity, magnetism, temperature, and humidity) materials in recent years. The physical and chemical properties of hydrogels have been used to construct hydrogel micro-nano robots which have demonstrated significant promise for biomedical applications. The different responsive deformation mechanisms in hydrogels are initially discussed in this study; after which, a number of preparation techniques and a variety of structural designs are introduced. This study also highlights the most recent developments in hydrogel micro-nano robots’ biological applications, such as drug delivery, stem cell treatment, and cargo manipulation. On the basis of the hydrogel micro-nano robots’ current state of development, current difficulties and potential future growth paths are identified.

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Section: Drug Deliverymentioning

confidence: 99%

Biomedical Applications of Deformable Hydrogel Microrobots

Cao,

Chen,

Zhong

et al. 2023

Micromachines

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Injectable Dynamic Hydrogel with Responsive Mechanical Reinforcing Ability Reverses Intervertebral Disc Degeneration by Suppressing Ferroptosis and Restoring Matrix Homeostasis

Wang,

Tan,

Zhang

et al. 2023

Adv Funct Materials

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Intervertebral disc degeneration (IDD) remains an essential challenge in the clinics due to the ferroptosis of nucleus pulposus cells (NPCs) and the imbalance of extracellular matrix (ECM) metabolism. Here, a dynamic hydrogel (HPGO) based on oxidized hyaluronic acid (OHA) and polyvinyl alcohol (PVA) for the integration of oridonin (Ori)‐loaded NPC membrane‐based nanovesicles is proposed, which is further grafted with growth and differentiation factor 5 (GDF5) on the OHA chain via Schiff base ligation. The precursors can rapidly form mechanically resilience hydrogels after injection into nucleus pulposus (NP) through the formation of various dynamic bonds. Meanwhile, the acidic pH in the degenerated NP can trigger the responsive release of GDF5, which may cooperate with Ori to alleviate inflammation in the microenvironment for restoring the metabolic homeostasis of ECM. In addition, the Schiff base moieties in HPGO hydrogel can scavenge free ferrous ions in the microenvironment to strengthen the dynamic bonds for self‐regulated reinforcement, thus providing mechanical support for the degenerated intervertebral discs (IVDs). Furthermore, HPGO hydrogel can enhance ferroptosis resistance of NPCs by activating the nuclear factor erythoid 2‐related factor 2 signaling pathway. Overall, HPGO hydrogel can mechanically support the damaged IVDs as well as reversing their degenerative status through cooperative ferroptosis inhibition, which provides an approach for the clinical treatment of IDD.

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Hydrophobic and Adhesive Elastomer Encapsulation for Anti‐Drying, Non‐Swelling, and Adhesive Hydrogels

Yuan,

Zhu,

Huang

et al. 2024

Adv Funct Materials

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Traditional hydrogels often face issues like dehydration, excessive swelling, and poor adhesion, limiting their practical applications. This study presents a facile and universal method to create elastomer‐encapsulated hydrogels with improved water retention, non‐swelling, and enhanced adhesion. n‐Butyl acrylate (BA) and 2,2,3,4,4,4‐hexafluorobutyl methacrylate (HFBMA) are utilized as the “soft” and “hard” monomers, respectively, to in situ construct the elastomer coatings on the hydrogel surface through surface‐confined copolymerization. The resulting transparent, hydrophobic, and adhesive elastomer coating is tightly bound to the hydrogel surface, conferring upon it a robust defense against dehydration and swelling in various media, and strong adhesion to diverse substrates in both aerial and submerged conditions. Furthermore, this encapsulation strategy also augments the mechanical attributes of the bulk hydrogel, including its tensile properties and puncture resistance, and is applicable to a wide array of hydrogel types and configurations. Additionally, the in situ encapsulation method applied to conductive hydrogels results in flexible sensors with high sensitivity, reversible resistance change, exceptional sensing stability, and significantly enhanced durability in both air and underwater environments. These properties suggest potential applications in harsh environments, such as underwater acoustic detection and sonar scanning camouflage for submarines.

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Mechanoresponsive Drug Release from a Flexible, Tissue‐Adherent, Hybrid Hydrogel Actuator

Cited by 22 publications

References 44 publications

Biomedical Applications of Deformable Hydrogel Microrobots

Biomedical Applications of Deformable Hydrogel Microrobots

Injectable Dynamic Hydrogel with Responsive Mechanical Reinforcing Ability Reverses Intervertebral Disc Degeneration by Suppressing Ferroptosis and Restoring Matrix Homeostasis

Hydrophobic and Adhesive Elastomer Encapsulation for Anti‐Drying, Non‐Swelling, and Adhesive Hydrogels

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