Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator Tono

Zhang, Xu; Avellaneda, Jerome; Spletter, Maria L.; Lemke, Sandra B.; Mangeol, Pierre; Habermann, Bianca H.; Schnorrer, Frank

doi:10.1016/j.cub.2024.07.079

Current Biology

2024

DOI: 10.1016/j.cub.2024.07.079

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Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator Tono

Xu Zhang,

Jerome Avellaneda,

Maria L. Spletter

et al.

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2024

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Transcriptional Dynamics Uncover the Role of BNIP3 in Mitophagy during Muscle Remodeling inDrosophila

Taoka,

Murakawa,

Kohei

et al. 2024

Preprint

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Differentiated muscle cells contain myofibrils and well-organized organelles, enabling powerful contractions. Muscle cell reorganization occurs in response to various physiological stimuli; however, the mechanisms behind this remodeling remain enigmatic due to the lack of a genetically trackable system. Previously, we reported that a subset of larval muscle cells is remodeled into adult abdominal muscle through an autophagy-dependent mechanism in Drosophila. To unveil the underlying mechanisms of this remodeling, we performed a comparative time-course RNA-seq analysis of isolated muscle cells with or without autophagy. It revealed both transcriptional dynamics independent of autophagy and highlighted the significance of BNIP3-mediated mitophagy in muscle remodeling. Mechanistically, we found that BNIP3 recruits autophagic machinery to mitochondria through its LC3-interacting (LIR) motif and minimal essential region (MER), which interact with Atg8a and Atg18a, respectively. Loss of BNIP3 leads to a substantial accumulation of larval mitochondria, ultimately impairing muscle remodeling. In summary, this study demonstrates that BNIP3-dependent mitophagy is critical for orchestrating the dynamic process of muscle remodeling.

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Transcriptional Dynamics Uncover the Role of BNIP3 in Mitophagy during Muscle Remodeling inDrosophila

Taoka,

Murakawa,

Kohei

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator Tono

Cited by 1 publication

References 107 publications

Transcriptional Dynamics Uncover the Role of BNIP3 in Mitophagy during Muscle Remodeling inDrosophila

Transcriptional Dynamics Uncover the Role of BNIP3 in Mitophagy during Muscle Remodeling inDrosophila

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