Mechanosensation circuitry in Caenorhabditis elegans: A focus on gentle touch

Campbell, Jason C.; Chin-Sang, Ian D.; Bendena, William G.

doi:10.1016/j.peptides.2014.12.004

Cited by 11 publications

(10 citation statements)

References 78 publications

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“…From a functional connectomic perspective, this suggests that not all stimuli utilize the same pathways and connections. This suggests a non-linearity and complexity in the information processing of stimuli, for example, the polymodal, amphid, single-ciliated, nociceptive neuron, ASH, detects a myriad of different mechano, osmo, and chemo stimuli that result in aversive behaviors [23,24,25,26,27,28,29]. The diversity in neuronal circuitries may also be due to the intracellular machinery used within individual neurons.…”

Section: Functional Characterization Of Neural Circuits: Using Conmentioning

confidence: 99%

Novel Technological Advances in Functional Connectomics in C. elegans

DiLoreto

Chute

Bryce

et al. 2019

JDB

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The complete structure and connectivity of the Caenorhabditis elegans nervous system (“mind of a worm”) was first published in 1986, representing a critical milestone in the field of connectomics. The reconstruction of the nervous system (connectome) at the level of synapses provided a unique perspective of understanding how behavior can be coded within the nervous system. The following decades have seen the development of technologies that help understand how neural activity patterns are connected to behavior and modulated by sensory input. Investigations on the developmental origins of the connectome highlight the importance of role of neuronal cell lineages in the final connectivity matrix of the nervous system. Computational modeling of neuronal dynamics not only helps reconstruct the biophysical properties of individual neurons but also allows for subsequent reconstruction of whole-organism neuronal network models. Hence, combining experimental datasets with theoretical modeling of neurons generates a better understanding of organismal behavior. This review discusses some recent technological advances used to analyze and perturb whole-organism neuronal function along with developments in computational modeling, which allows for interrogation of both local and global neural circuits, leading to different behaviors. Combining these approaches will shed light into how neural networks process sensory information to generate the appropriate behavioral output, providing a complete understanding of the worm nervous system.

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Section: Functional Characterization Of Neural Circuits: Using Conmentioning

confidence: 99%

Novel Technological Advances in Functional Connectomics in C. elegans

DiLoreto

Chute

Bryce

et al. 2019

JDB

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“…By contrast, touching a worm on the posterior end triggers sensation by cells PLM and PVM, which results in forward movement generated by PVC, AVB, VB, and DB motor neurons ( Pirri and Alkema, 2012 ). Additional cells such as ASH and RIM are involved in the control of head and recoil movements, respectively ( Zhao et al, 2003 ; Campbell et al, 2015 ). While our first-mover strategies do not explain the emergence of this circuit, cells associated with two behavioral components (reversal and head control and recoil) correspond to two sets of strategies: the P–N strategy for cells ASH and RIM head control and recoil), and the XOR first-mover and XOR second-mover strategies for cells ALM, AVA, AVB, and AVD (reversal).…”

Section: Discussionmentioning

confidence: 99%

Raising the Connectome: The Emergence of Neuronal Activity and Behavior in Caenorhabditis elegans

Alicea

2020

Front. Cell. Neurosci.

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The differentiation of neurons and formation of connections between cells is the basis of both the adult phenotype and behaviors tied to cognition, perception, reproduction, and survival. Such behaviors are associated with local (circuits) and global (connectome) brain networks. A solid understanding of how these networks emerge is critical. This opinion piece features a guided tour of early developmental events in the emerging connectome, which is crucial to a new view on the connectogenetic process. Connectogenesis includes associating cell identities with broader functional and developmental relationships. During this process, the transition from developmental cells to terminally differentiated cells is defined by an accumulation of traits that ultimately results in neuronal-driven behavior. The well-characterized developmental and cell biology of Caenorhabditis elegans will be used to build a synthesis of developmental events that result in a functioning connectome. Specifically, our view of connectogenesis enables a first-mover model of synaptic connectivity to be demonstrated using data representing larval synaptogenesis. In a first-mover model of Stackelberg competition, potential pre- and postsynaptic relationships are shown to yield various strategies for establishing various types of synaptic connections. By comparing these results to what is known regarding principles for establishing complex network connectivity, these strategies are generalizable to other species and developmental systems. In conclusion, we will discuss the broader implications of this approach, as what is presented here informs an understanding of behavioral emergence and the ability to simulate related biological phenomena.

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“…It is well documented how in the C. elegans connectome, a single neuronal class can be involved in the sensation of diverse stimuli or elicit different behaviors. For example, the polymodal, nociceptive neuron, ASH, detects a myriad of different mechano-, osmo-, and chemo-stimuli that result in aversive behavior (22)(23)(24)(25)(26)(27)(28). However, not all stimuli utilize the same pathways and connections as one might expect given detection by a single sensory neuron serving as progenitor for these circuits.…”

Section: Functional Focusmentioning

confidence: 99%

Functional Connectomics in <em>C. elegans</em>

DiLoreto¹,

Chute²,

Bryce³

et al. 2018

Preprint

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The complete structure and connectivity of the Caenorhabditis elegans nervous system was first published in 1986. The ‘mind of a worm’ was the first organism to have its nervous system to be reconstructed at the level of synapses, and represented a critical milestone considering today it remains the only organism to be mapped to that level of connection. Recently, the extrasynaptic connectome of neuropeptides and monoamines has been described. This review discusses recent technological advances used to perturb whole-organism neuronal function, such as: whole brain imaging, optogenetics, sonogenetics and mutant analysis, which have allowed for interrogations of both local and global neural circuits, leading to different behaviors. A better understanding of a whole organism requires combining experimental datasets with biophysical neuronal modelling, and behavioral quantification. Combining these approaches will provide a complete understanding of the worm nervous system and shed light into how networks function and interact with the synaptic network to modulate information processing and behavioral output.

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Mechanosensation circuitry in Caenorhabditis elegans: A focus on gentle touch

Cited by 11 publications

References 78 publications

Novel Technological Advances in Functional Connectomics in C. elegans

Novel Technological Advances in Functional Connectomics in C. elegans

Raising the Connectome: The Emergence of Neuronal Activity and Behavior in Caenorhabditis elegans

Functional Connectomics in <em>C. elegans</em>

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