Mechanosensitive Channel Activation by Diffusio-Osmotic Force

Bonthuis, Douwe Jan; Golestanian, Ramin

doi:10.1103/physrevlett.113.148101

Cited by 15 publications

(15 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent work has even shown that the diffusioosmotic force, arising from the interactions of nonuniform solute with channel boundaries, is critical for the activation of mechanosensitive channels. 3 On the other hand, chemical gradients have been exploited in synthetic microfluidic systems. [4][5][6] Particularly, the diffusio-osmosis was recently proposed to pump fluids, 7,8 manipulate mesoscale particles, 9,10 and to harvest chemical energy.…”

Section: Introductionmentioning

confidence: 99%

Chemically driven fluid transport in long microchannels

Shen

et al. 2016

The Journal of Chemical Physics

View full text Add to dashboard Cite

Chemical gradients maintained along surfaces can drive fluid flows by diffusio-osmosis, which become significant at micro- and nano-scales. Here, by means of mesoscopic simulations, we show that a concentration drop across microchannels with periodically inhomogeneous boundary walls can laterally transport fluids over arbitrarily long distances along the microchannel. The driving field is the secondary local chemical gradient parallel to the channel induced by the periodic inhomogeneity of the channel wall. The flow velocity depends on the concentration drop across the channel and the structure and composition of the channel walls, but it is independent of the overall channel length. Our work thus presents new insight into the fluid transport in long microchannels commonly found in nature and is useful for designing novel micro- or nano-fluidic pumps.

show abstract

Section: Introductionmentioning

confidence: 99%

Chemically driven fluid transport in long microchannels

Shen

et al. 2016

The Journal of Chemical Physics

View full text Add to dashboard Cite

show abstract

“…T he dynamics of nano-confined liquids are central to processes such as filtration, energy storage, lubrication, cell membrane pumps and channels, and a multitude of other technological and biological scenarios. When the confinement lengthscale is comparable to the molecular size of the contained liquid a spectrum of dynamic phenomena are possible depending on the detailed intermolecular and surface interactions at play (1)(2)(3)(4)(5)(6). In light of such strong relevance it is surprising that one of the simplest model systems of confined fluid -a non-polar molecular liquid confined between two atomically smooth surfaces -still evades full explanation.…”

mentioning

confidence: 99%

Solidification and superlubricity with molecular alkane films

Smith

Hallett

Perkin

2019

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Hydrocarbon films confined between smooth mica surfaces have long provided an experimental playground for model studies of structure and dynamics of confined liquids. However fundamental questions regarding the phase behavior and shear properties in this simple system remain unsolved. With ultra-sensitive resolution in film thickness and shear stress, and control over the crystallographic alignment of the confining surfaces, we here investigate the shear forces transmitted across nanoscale films of dodecane down to a single molecular layer. We resolve the conditions under which liquidsolid phase transitions occur and explain friction coefficients spanning several orders of magnitude. We find that commensurate surface alignment and presence of water at the interfaces each lead to moderate or high friction, whereas friction coefficients down to µ ∼ 0.001 are observed for a single molecular layer of dodecane trapped between crystallographically misaligned dry surfaces. This ultralow friction is attributed to sliding at the incommensurate interface between one of the mica surfaces and the laterally ordered solid molecular film, reconciling previous interpretations.Confined liquids | Nanotribology | Friction mechanisms | Surface Force Apparatus www.pnas.org/cgi/

show abstract

“…On the other hand, continuum modeling has been adopted widely in recent studies where the transduction of membrane tension to SA channels is found to depend on the molecular details of lipid binding in the channels (13). For example, the channel gating was shown to depend on the protein surface charge and hydrophobicity (23).…”

mentioning

confidence: 99%

“…Such idealized model systems for gating of MS channels in cells are suitable for elucidating the detailed gating mechanism coupled with the membrane dynamics, which is intrinsically multiscale both in space and in time. Coarse-grained MD simulations of such systems would take too long, given the current computational power, and thus are not practical.Motivated by the recent success of continuum modeling of MS channels (13,20,23), in this paper we propose a multiscale continuum model to study the gating of a single MS channel by tension in a membrane exposed to fluid stress. In particular, as highlighted in Fig.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Gating of a mechanosensitive channel due to cellular flows

Pak

Young

Marple

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

A multiscale continuum model is constructed for a mechanosensitive (MS) channel gated by tension in a lipid bilayer membrane under stresses due to fluid flows. We illustrate that for typical physiological conditions vesicle hydrodynamics driven by a fluid flow may render the membrane tension sufficiently large to gate a MS channel open. In particular, we focus on the dynamic opening/ closing of a MS channel in a vesicle membrane under a planar shear flow and a pressure-driven flow across a constriction channel. Our modeling and numerical simulation results quantify the critical flow strength or flow channel geometry for intracellular transport through a MS channel. In particular, we determine the percentage of MS channels that are open or closed as a function of the relevant measure of flow strength. The modeling and simulation results imply that for fluid flows that are physiologically relevant and realizable in microfluidic configurations stress-induced intracellular transport across the lipid membrane can be achieved by the gating of reconstituted MS channels, which can be useful for designing drug delivery in medical therapy and understanding complicated mechanotransduction. M echanosensitive (MS) channels are essential to mechanosensation and mechanotransduction in a wide range of cells (1-3). Due to the great diversity of MS channels, the general gating mechanism is found to depend on combinations of the detailed molecular structures (4-7), the gating-associated conformational changes (8-10), and coupling with the lipid bilayer membrane (11)(12)(13)(14). It remains a challenge to elucidate general mechanisms underpinning the gating of MS channels. In this spirit it is useful to have "simple" models to understand the complex response of MS channels and their associated biological functions (15).Stretch-activated (SA) channels are a class of (relatively) simpler MS channels that are stretched open mainly by membrane tension (e.g., due to osmotic shock, stress from fluid flow, or other mechanical sources of tension) for nonselective intracellular transport of ions and macromolecules (16)(17)(18)(19). Their gating mechanisms have been investigated by experiments (18), continuum modeling (20, 21), and molecular dynamics (MD) simulations (22). By exerting an unphysiologically large load onto a membrane patch with a single SA channel in the center, MD simulations show that a SA channel (several nanometers in size) responds to membrane tension within a few nanoseconds (22). Due to computational limitations, MD simulations are restricted to a small lipid patch and a short timescale (approximately microseconds). On the other hand, continuum modeling has been adopted widely in recent studies where the transduction of membrane tension to SA channels is found to depend on the molecular details of lipid binding in the channels (13). For example, the channel gating was shown to depend on the protein surface charge and hydrophobicity (23).Novel technological advancements in microfluidics have made it possible to construct...

show abstract

Mechanosensitive Channel Activation by Diffusio-Osmotic Force

Cited by 15 publications

References 49 publications

Chemically driven fluid transport in long microchannels

Chemically driven fluid transport in long microchannels

Solidification and superlubricity with molecular alkane films

Gating of a mechanosensitive channel due to cellular flows

Contact Info

Product

Resources

About