2022
DOI: 10.1186/s12931-022-02122-6
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Mechanosensitive Piezo channels mediate the physiological and pathophysiological changes in the respiratory system

Abstract: Mechanosensitive Piezo ion channels were first reported in 2010 in a mouse neuroblastoma cell line, opening up a new field for studying the composition and function of eukaryotic mechanically activated channels. During the past decade, Piezo ion channels were identified in many species, such as bacteria, Drosophila, and mammals. In mammals, basic life activities, such as the sense of touch, proprioception, hearing, vascular development, and blood pressure regulation, depend on the activation of Piezo ion chann… Show more

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Cited by 12 publications
(8 citation statements)
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“…Piezo channels—vertebrate mechanically activated nonselective cation channels—are a more recently discovered member of the SACs family, 31 whose role has been widely implicated in mechanosensing. Whereas Piezo1 initiates Ca 2+ signals predominantly in various non-excitable cells, 31 Piezo2 mainly functions in sensory neurons and specialized cell types, such as tactile epithelial cells (e.g., Merkel cells 31 ).…”
Section: Mechanotransductionmentioning
confidence: 99%
See 2 more Smart Citations
“…Piezo channels—vertebrate mechanically activated nonselective cation channels—are a more recently discovered member of the SACs family, 31 whose role has been widely implicated in mechanosensing. Whereas Piezo1 initiates Ca 2+ signals predominantly in various non-excitable cells, 31 Piezo2 mainly functions in sensory neurons and specialized cell types, such as tactile epithelial cells (e.g., Merkel cells 31 ).…”
Section: Mechanotransductionmentioning
confidence: 99%
“…Piezo channels—vertebrate mechanically activated nonselective cation channels—are a more recently discovered member of the SACs family, 31 whose role has been widely implicated in mechanosensing. Whereas Piezo1 initiates Ca 2+ signals predominantly in various non-excitable cells, 31 Piezo2 mainly functions in sensory neurons and specialized cell types, such as tactile epithelial cells (e.g., Merkel cells 31 ). Piezo channels can be activated by membrane tension (force-from-lipid), indicating that any physiological force that can cause indentation of the cell membrane on the apical surface-lumen facing side and hence alter the membrane tension, such as that produced with a blunt glass probe or suction to the membrane, can robustly activate the piezo channel.…”
Section: Mechanotransductionmentioning
confidence: 99%
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“…39 Piezo1 is also expressed in ATI cells and is indirectly implicated in the regulation of surfactant production in ATII cells. 40,70 These findings point to a growing recognition for Piezo channels in regulating many aspects of airway and lung physiology.…”
Section: Calcium Signaling In the Airway Epithelium: General Principl...mentioning
confidence: 97%
“…68 In the lung, Piezo1 expression in lung endothelial and smooth muscle cells is associated with pulmonary hypertension and ventilator-induced lung injury. 69,70 Moreover, Piezo1 is expressed in ATII cells in mice and implicated in mechanical stretch-induced apoptosis of alveolar type II cells through the Bcl-2 pathway during acute respiratory distress syndrome. 39 Piezo1 is also expressed in ATI cells and is indirectly implicated in the regulation of surfactant production in ATII cells.…”
Section: Calcium Signaling In the Airway Epithelium: General Principl...mentioning
confidence: 99%