This article focuses on the transformative potential of mechatronics in up-to-date textiles and clothing industries, with a special focus on its implications for automation, efficiency in production, and product quality. Supported in the mechatronic systems by the sensors and control elements, precise textile production with almost no defects and an improved uniformity property is achieved. To adapt to it, mechatronics makes design changes easily and quickly, to quickly satisfy consumers' spending. Furthermore, mechatronics reduces costs and waste while saving resources in hand with enhancing fabric inspection with new sensor technology. The chapter underscores four key applications—intelligent textile systems, automated manufacturing, smart clothing and wearables, testing and analysis of textiles and clothing—supported by relevant examples from authors' studies.