Meconium aspiration syndrome: incidence, associated risk factors and outcome‐evidence from a multicentric study in low‐resource settings in Nepal

Paudel, Prajwal; Sunny, Avinash K; Poudel, Prakash; Gurung, Rejina; Gurung, Abhishek; Bastola, Ramchandra; Chaudhary, Ram Narayan; Budhathoki, Shyam Sundar; Ashish, K C

doi:10.1111/jpc.14703

Cited by 15 publications

(10 citation statements)

References 18 publications

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“…The incidence of MAS was high in Nepal with an overall incidence of about 2.0 per 1000 live births. 11 Studies conducted in Nepal have revealed the prevalence of MSAF about 6.5%-14.6%, 8 , 9 , 12 among all live deliveries, the prevalence of MAS among MSAF about 6.6% to 8.6%, 8 , 12 and neonatal mortality from MAS about 5.4% to 11.3%. 8 , 9 , 12 The study conducted in India found the prevalence of MAS among MSAF as 7.7% to 21.5%, 4 - 6 and mortality among MAS as high as 13.8%.…”

Section: Discussionmentioning

confidence: 99%

Neonates Born Through Meconium-stained Amniotic Fluid among Deliveries in a Tertiary Care Centre: A Descriptive Cross-sectional Study

2022

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Introduction: The mortality and morbidity of meconium aspiration syndrome in neonates born with meconium-stained amniotic fluid in developing countries are still high. In Nepal, few studies have estimated the prevalence of meconium-stained amniotic fluid among newborns. The study aimed to find out the prevalence of neonates born through meconium-stained amniotic fluid among deliveries in a tertiary care centre. Methods: This descriptive cross-sectional study was conducted among neonates born in a tertiary care centre from November 2021 to March 2022. Neonates born during the study period with meconium-stained amniotic fluid were studied. Ethical approval was obtained from the Institutional Review Committee. Convenience sampling method was used. With permission from the Department of the Neonatal Intensive Care Unit, the data were collected and entered in a Microsoft Excel sheet. Point estimate and 95% Confidence Interval were calculated. Results: Among 576 neonates, the prevalence of neonates born through meconium-stained amniotic fluid was 77 (13.37%) (10.59-16.15, 95% Confidence Interval). Conclusions: The prevalence of neonates born through meconium-stained amniotic fluid was found to be similar to other studies done in similar settings.

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Section: Discussionmentioning

confidence: 99%

Neonates Born Through Meconium-stained Amniotic Fluid among Deliveries in a Tertiary Care Centre: A Descriptive Cross-sectional Study

2022

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“…13 In the present study, there were 82 (41%) patients who had grade I MSL, 63 (31.5%) patient who had grade II MSL whereas 55 (27.5%) patients who had grade III MSL. Paudel P et al 14 studied incidence, associated risk factors and outcome evidence of meconium aspiration syndrome in Nepal. In their study, 11/122(9%) cases of MAS were among multiparous women, 78/122(63.9%) cases of MAS were among nulliparous women and 33/122(27%) cases of MAS were among primiparous women.…”

Section: Discussionmentioning

confidence: 99%

Maternal and fetal characteristics associated with meconium-stained amniotic fluid

Patel¹,

Patel²,

Shah³

et al. 2020

IJOGR

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Black-green colored odorless material known as meconium is physiologically passed by new born babies with in 48 hours of birth. Presence of meconium in the amniotic fluid could be a dangerous condition. It may expose the baby to multiple condition depending upon the amount of meconium entering in to the respiratory track of the baby. The knowledge of association of various maternal and fetal associated factors with meconium aspiration syndrome is of immense importance for appropriate clinical judgments and decisions. The aim of the present study was to study various maternal and fetal parameters associated with meconium stained amniotic fluid. The present study was a prospective observational study. It was conducted in the Obstetrics and Gynecology department of Tertiary Hospital & Medical Collage & Research Centre, Ahmedabad, Gujarat, India during May 2016 to May 2018 on 200 laboring mothers with meconium stained amniotic fluid who delivered or underwent cesarean section in the institute were included in the study. Majority of them were between 20–30 years of age (59%). The women between 31–35 years of age were 27%. Participants either <20 years or >35 years were 9% and 5% respectively. There were 82 patients who had grade I MSL, 63 patient who had grade II MSL whereas 55 patients who had grade III MSL. Out of 200, there were 196 women who were having associated risk factors like prolonged labour, PROM, hypertension, postdatism, GDM, IUGR and anaemia. MSL as well as MAS has been strongly associated with the parity of the mother. It was also observed that patients who’s age was greater than 35 yrs. All (100%) presented with grade 3 MSL. Fetus whose gestational age was greater than 40 weeks has fewer chances of co-morbidities. It was concluded in the present study that multiparity, higher maternal age, presence of Maternal Risk Factors, C-section, IUGR, oligo-hydraminos, post-datism, GDM, non-reactive CTG, prolonged labor and PROM had significant association with higher grades of meconium stained Liquor. It is strongly recommend that in such patients early and appropriate care along with constant monitoring can prove to be highly beneficial.

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“…Su incidencia varía entre 0,4 y 4 por 1.000 nacidos vivos (1)(2)(3). En los países desarrollados ha disminuido en los últimos años a raíz del cambio de las prácticas obstétricas (4).…”

Section: Introductionunclassified

Síndrome De Aspiración Meconial: Revisión De La Fisiopatología Y Estrategias De Manejo

Encina

2022

Neumol Pediatr

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El síndrome de aspiración meconial, es una condición clínica caracterizada por insuficiencia respiratoria que ocurre en neonatos nacidos a través de líquido amniótico teñido de meconio, y que puede presentarse como una enfermedad grave con riesgo vital. Su incidencia ha disminuido gracias a mejores prácticas obstétricas y atención perinatal y se ha observado una mejoría en la sobrevida, gracias a mejores prácticas en la UCI neonatal. Sin embargo, el abordaje más adecuado sigue siendo un tema de debate, dado que hasta el momento se basa sólo en medidas de soporte, sin que existan medidas que actúen sobre los mecanismos de daño. Por otro lado, la morbilidad a largo plazo entre los sobrevivientes sigue siendo una preocupación importante. Esta revisión ofrece una visión general actualizada de la epidemiología, la fisiopatología, el diagnóstico, el manejo terapéutico, la prevención y el pronóstico de los pacientes que presentan este cuadro.

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Meconium aspiration syndrome: incidence, associated risk factors and outcome‐evidence from a multicentric study in low‐resource settings in Nepal

Cited by 15 publications

References 18 publications

Neonates Born Through Meconium-stained Amniotic Fluid among Deliveries in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Neonates Born Through Meconium-stained Amniotic Fluid among Deliveries in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Maternal and fetal characteristics associated with meconium-stained amniotic fluid

Síndrome De Aspiración Meconial: Revisión De La Fisiopatología Y Estrategias De Manejo

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