Meconium Aspiration Syndrome (MAS)

Uslu, Sinan; Dursun, Mesut; Bülbül, Ali

doi:10.5350/semb.20150430023217

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…PPHT has been reported at a rate of 6-25% in newborns with HIE who were enrolled in clinical studies of head and whole-body cooling, which is higher than the rate in the general population. [ 11 , 12 ] Shankaran et al [ 13 ] , who investigated the relationship between the degree of hypothermia and PPHT, demonstrated that when patients were cooled to 33.5 and 32 o C for 72 or 120 hours, the need for iNO and extracorporeal membrane oxygenation (ECMO) increased in the group cooled to 32 o C. They also demonstrated that the mild hypothermia used in HIE treatment was not associated with PPHT. Six of our patients (four with MAS and two with IUGR) received therapeutic hypothermia for HIE, and their body temperatures were maintained within the range of 33.5-34.5 o C.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors and Mortality in Newborns with Persistent Pulmonary Hypertension: A Six-Year Single-Center Experience

Sahin

2024

Sisli Etfal

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Objectives Persistent pulmonary hypertension (PPHT) of the newborn is a disorder of circulatory transition resulting in high pulmonary vascular resistance with extrapulmonary right-to-left shunts causing hypoxemia. In this study, our aim was to evaluate the risk factors, administered treatments, and mortality of patients followed in our neonatal intensive care unit (NICU) due to PPHT over the past six years. Methods Patients diagnosed with PPHT and followed in the NICU between January 2017 and November 2022 were included in the study. The sociodemographic characteristics, diagnoses that could lead to pulmonary hypertension, the presence of congenital anomalies, the duration of respiratory support treatment and hospital follow-up, treatments administered for PPHT, and mortality rates were evaluated. Results Out of 21 patients diagnosed with persistent pulmonary hypertension, 9 of them (42.9%) were male. The mean gestational age of the patients was 37.6±3.7 weeks, and their birth weight was 3006±819grams. The APGAR scores at 1 and 5 minutes were 4(2-7) and 6(3-8), respectively. Risk factors during the antenatal period included fetal distress (38.1%), oligohydramnios (23.8%), intrauterine growth restriction (23.8%), gestational diabetes (14.3%), preeclampsia (4.8%), and chorioamnionitis (4.8%). The median duration of invasive mechanical ventilation for cases requiring respiratory support was 20.1 days, while the median duration of non-invasive ventilation was 3.7 days. Patients with a diagnosis of persistent pulmonary hypertension were treated with inhaled nitric oxide (iNO) in 76.2% of cases, milrinone in 66.7% of cases, sildenafil in 52.4% of cases, and iloprost in 14.3% of cases. The length of hospital stay for patients was 38.4 days, and 9 (42.9%) patients died. The patients who died had severe PPHT along with fetal inflammatory response syndrome (FIRS), congenital heart disease, pulmonary hypoplasia, pneumothorax, hypoxic-ischemic encephalopathy (HIE), and congenital anomalies. Conclusion Persistent pulmonary hypertension, characterized by severe hypoxemia, is a neonatal emergency that necessitates early intervention, effective treatment of the underlying cause to prevent potential short-term and long-term morbidities and mortality. Effective treatment of the underlying cause in patients diagnosed with PPHT could reduce morbidity and mortality. It is inevitable to avoid the loss of patients with major abnormalities, severe comorbidities, and unpreventable organ dysfunctions.

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Section: Discussionmentioning

confidence: 99%

Risk Factors and Mortality in Newborns with Persistent Pulmonary Hypertension: A Six-Year Single-Center Experience

Sahin

2024

Sisli Etfal

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“…The European Research Journal 2019;5 (5):776-780 iagnosis of meconium aspiration syndrome (MAS) is made by the presence of respiratory distress and other characteristic radiologic findings in babies born with meconium-stained amniotic fluid (MSAF) [1, 2,]. In the healthy newborn, the first meconium outflow is between 24 th and 48 th hours and it is rarely seen between 20 and 34 weeks of pregnancy [1,2].…”

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confidence: 99%

“…Meconium causes harm in lungs with various mechanisms and that was defined as MAS by the presence of respiratory distress and other characteristic radiologic findings in babies born with MSAF [2,5]. The clinical picture may vary from mild respiratory distress to severe respiratory failure.…”

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confidence: 99%

The incidence and clinical features of meconium aspiration syndrome: a two-year neonatal intensive care experience

Fedakar

2019

The European Research Journal

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Objectives: The aim of this present study was to review the clinical characteristics, risk factors, frequency of meconium aspiration syndrome (MAS), development and maternal demographic characteristics of the newborns born with meconium stained amniotic fluid (MSAF) in our neonatal intensive care unit. Methods: The files of the patients hospitalized in our neonatal intensive care unit between July 31, 2015 and July 31, 2017 and who were diagnosed with MAS or MBAS were examined retrospectively. Results: A total of 1410 patients were included during this period. Of these patients, 98 were term infants and 3 (34 weeks) were preterm infants. One hundred and one infants (7.1%) had MSAF and/or MAS. Of the patients, 63 were boys, 38 were girls. MAS developed in 61 patients (60.3%) who were hospitalized due to MBAS. No difference was detected between two groups in terms of the systemic diseases, age, pregnancy number, gestation week, delivery type, length of hospital stay of mother and birth weight of infant. The fifth minute Apgar score and need for resuscitation were found to be statistically significant in patients with MAS. We did not have any mortality. Conclusion: MAS frequency decreases in parallel with the developments in neonatal care but it is still a major cause of mortality and morbidity. We believe that chance of mortality and morbidity will decrease thanks to the close follow-up and early treatment in infants born with MSAF who are likely to develop MAS.

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Yenidoğanın Doğum Odasında Aspirasyon İlkelerinde Güncel Yaklaşımlar; Ebelerin Rol ve Sorumlulukları

Batman¹

2020

Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi

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Neonatatal mortalite istatistikleri incelendiğinde, önemli bir bölümünün yaşamın ilk günü meydana geldiği görülmektedir. Bu durum yenidoğanın doğum odasındaki bakım ve izleminin ne kadar önemli olduğunu ortaya koymaktadır. Doğum odasında yenidoğanlara yapılan uygulamalar arasında yer alan aspirasyon işlemi yaygın olarak kullanılmaktadır. Aspirasyon işlemine bağlı solunum ve dolaşım sisteminin çalışmasını olumsuz etkileyen birçok komplikasyon gelişebilmektedir. Bu açıdan yenidoğanda dikkatli uygulanması gereken bir girişimdir. Yıllar içerisinde yenidoğanlara doğum odasında yaklaşım uygulamaları değişiklik göstermiştir. Yenidoğan bakımına yön veren Dünya Sağlık Örgütü, Türk Neonatoloji Derneği, Amerikan Kalp Derneği ve Uluslararası Resüsitasyon Komitesi'nin güncel önerileri incelendiğinde, yenidoğanlara rutin aspirasyon işlemi önerilmemektedir. Ebelerin görev ve sorumlulukları arasında yenidoğanın ilk bakım ve muayenesi ve gerektiğinde acil resüsitasyon gerçekleştirmesi de yer almaktadır. Bu durum ebelerin yenidoğanın aspirasyon işleminde anahtar role sahip olduğunu göstermektedir. Bu açıdan ebelerin yenidoğanda aspirasyon ilkeleri hakkında ayrıntılı bilgi sahibi olması ve konuyla ilgili güncel yaklaşımları bilmesi önemli bir konudur. Aspirasyon yenidoğanlara doğum odasında oro-nazofarenks, endotrakeal ve mide içeriği aspirasyonu yöntemlerinde uygulanmakta ve ebelik bakımında önemli yer tutmaktadır. Bu makalede, yenidoğanın doğum odasında aspirasyon ilkelerinde güncel yaklaşımlar ve ebelerin rol ve sorumlulukları literatür bilgisi kapsamında derlenmiştir.

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Meconium Aspiration Syndrome (MAS)

Cited by 3 publications

References 31 publications

Risk Factors and Mortality in Newborns with Persistent Pulmonary Hypertension: A Six-Year Single-Center Experience

Risk Factors and Mortality in Newborns with Persistent Pulmonary Hypertension: A Six-Year Single-Center Experience

The incidence and clinical features of meconium aspiration syndrome: a two-year neonatal intensive care experience

Yenidoğanın Doğum Odasında Aspirasyon İlkelerinde Güncel Yaklaşımlar; Ebelerin Rol ve Sorumlulukları

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