2003
DOI: 10.1203/01.pdr.0000072784.55140.1e
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Meconium Induces Only Localized Inflammatory Lung Injury in Piglets

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Cited by 30 publications
(31 citation statements)
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“…24 However, several studies showed a benefit of corticosteroids in MAS. 13,15,16 Corticosteroids reduce edema formation through diminished endothelial damage and microvascular permeability.…”
Section: Discussionmentioning
confidence: 99%
“…24 However, several studies showed a benefit of corticosteroids in MAS. 13,15,16 Corticosteroids reduce edema formation through diminished endothelial damage and microvascular permeability.…”
Section: Discussionmentioning
confidence: 99%
“…19 Experimental study in piglet model suggests that meconium-induced inflammation is localized in the meconium-contaminated areas of the lungs with no generalized inflammatory injury. 20 Correspondingly, local accumulation of neutrophils and macrophages and production of IL-1b and tumor-necrosis factor-a (TNFa) cytokines have been observed. 2,20 Current experimental data suggests that intrapulmonary accumulation of activated neutrophils, similar to various forms of acute injury in adult lungs 21 could aggravate the hypoxic respiratory failure.…”
Section: Neutrophil Influxmentioning
confidence: 99%
“…20 Correspondingly, local accumulation of neutrophils and macrophages and production of IL-1b and tumor-necrosis factor-a (TNFa) cytokines have been observed. 2,20 Current experimental data suggests that intrapulmonary accumulation of activated neutrophils, similar to various forms of acute injury in adult lungs 21 could aggravate the hypoxic respiratory failure. Myeloperoxidase activity is usually used as an important indicator of neutrophil accumulation.…”
Section: Neutrophil Influxmentioning
confidence: 99%
“…4 In line with this finding, tissue PLA 2 activity and concentration of human pancreatic PLA 2 in the meconium-contaminated lungs are concentration-dependently elevated and correlate directly with the severity of the meconium-induced lung injury. 4,16,17 In these studies, promotion of lung edema formation and neutrophil influx through insufflated human PLA 2 -I, either in soluble form or within meconium, further substantiates the central role of pulmonary PLA 2 -I in the development of lung injury after meconium aspiration. 16,17 High PLA 2 activity in meconium, mainly due to secretory PLA 2 -I, is additionally shown to be associated with decreased surfactant biophysical activity in the affected lungs.…”
mentioning
confidence: 53%