MED1 Deficiency in Macrophages Aggravates Isoproterenol-Induced Cardiac Fibrosis in Mice

Characterization and comparative transcriptomic analysis of skeletal muscle in female Pekin duck and Hanzhong Ma duck during different growth stages using RNA-seq

“…Fibronectin 1 ( FN1 ) belongs to the FN family and is involved in various cellular biological processes related to cell fibrosis. FN1 can serve as a marker for fibroblast activation and is also a gene that promotes muscle fibrosis ( Sawaki et al, 2018 ; Fatima et al, 2022 ). In recent studies, both genomic methylation analysis of sheep skeletal muscle and transcriptome analysis of chicken leg skeletal muscle have indicated that FN1 was involved in the regulation of muscle development ( Xue et al, 2017 ; Yue et al, 2023 ).…”

Interleukin‐13 contributes to the occurrence of oral submucosal fibrosis

“…[11][12][13][14] Furthermore, IL-13 was associated with elevated production of total collagens in normal human skin and keloid fibroblasts (FBs), whereas FBs in various scarring diseases produced more fibrin, suggesting that IL-13 is associated with fibrosis. [15][16][17] Interestingly, a recent report demonstrated that in fibrosis, inhibition of both IL-13 and TGFβ signalling completely attenuated the fibrotic mechanism compared to TGFβ inhibition alone. 18 The Areca nut ranks fourth among the most commonly used addictive substances globally.…”

“…Studies have shown that IL‐13 contributes to the pathogenesis of fibroproliferative diseases, such as pulmonary fibrosis, liver cirrhosis, myocardial fibrosis, progressive kidney disease and pathological skin scarring, among others 11–14 . Furthermore, IL‐13 was associated with elevated production of total collagens in normal human skin and keloid fibroblasts (FBs), whereas FBs in various scarring diseases produced more fibrin, suggesting that IL‐13 is associated with fibrosis 15–17 . Interestingly, a recent report demonstrated that in fibrosis, inhibition of both IL‐13 and TGF‐β signalling completely attenuated the fibrotic mechanism compared to TGF‐β inhibition alone 18 …”