2015
DOI: 10.1007/s12088-015-0520-1
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Meddling Vibrio cholerae Murmurs: A Neoteric Advancement in Cholera Research

Abstract: Cholera, a known diarrheal disease is associated with various risk factors like hypovolemic shock, rice watery stools, and death in developing countries. The overuse of antibiotics to treat cholera imposed a selective pressure for the emergence and spread of multi-drug resistant Vibrio cholerae strains. The failure of conventional antimicrobial therapy urged the researchers to find an alternative therapy that could meddle the cholera murmurs (Quorum Sensing). It seems to effectively overcome the conventional c… Show more

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Cited by 10 publications
(7 citation statements)
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“…In kindred species like Vibrio cholerae, three QSSs, discerned, function concomitantly [44]: through regulatory small RNAs also termed as regulatory RNAs (Qrr): (1) Cholera Autoinducer-1 (CAI-1)/CqsS is responsible for communication at inter-and intra-species level [45], (2) Autoinducer-2 (AI-2)/LuxP/Q regulates inter species communication [45,46] and (3) QSS III regulated by VarS/ VarA [47]. VarS/VarA-CsrABCD system in association with the QSS of V. cholerae leads to the expression of the EDF signalling EDF (extracellular death factor) peptide, NNWNN Activation of toxin-antitoxin module [91] luxS AI-3/epinephrine/norepinephrine system Senses AI-3 produced by gut flora and epinephrine/ norepinephrine produced by host and induces virulence [93] Proteus mirabilis…”
Section: Vibriomentioning
confidence: 99%
“…In kindred species like Vibrio cholerae, three QSSs, discerned, function concomitantly [44]: through regulatory small RNAs also termed as regulatory RNAs (Qrr): (1) Cholera Autoinducer-1 (CAI-1)/CqsS is responsible for communication at inter-and intra-species level [45], (2) Autoinducer-2 (AI-2)/LuxP/Q regulates inter species communication [45,46] and (3) QSS III regulated by VarS/ VarA [47]. VarS/VarA-CsrABCD system in association with the QSS of V. cholerae leads to the expression of the EDF signalling EDF (extracellular death factor) peptide, NNWNN Activation of toxin-antitoxin module [91] luxS AI-3/epinephrine/norepinephrine system Senses AI-3 produced by gut flora and epinephrine/ norepinephrine produced by host and induces virulence [93] Proteus mirabilis…”
Section: Vibriomentioning
confidence: 99%
“…The review has highlighted the importance of QS pathway in S.mutans and its role in formation of biofilm along with other virulence properties. Quite a few efforts has been taken to modulate QS to reduce the production of biofilm and associated virulence factors like Hentzer and Givskov, Ravichandran et al, Arya et al, Hema et al, and Wright et al, have described the application of antagonists that act as QS inhibitors to attain the inhibition of virulence genes under QS circuit to prevent the various infections caused by Pseudomonas aeruginosa, Vibrio cholerae and Staphylococcus aureus [28,33,[70][71][72][73][74][75][76]. The approach ensures its success in the fact that, anti-quorum compounds may control virulence traits of pathogenic microbes without significant effects on viability of bacterial cells [77].…”
Section: Resultsmentioning
confidence: 99%
“…This further up regulates the gene expression of biofilm and virulence factors including TCP and CT. At HCD state, accumulation of AI leads to the removal of phosphate from LuxO by the phosphatase activity of the AI receptors. The inactive LuxO repress the sRNAs(Qrr1-4) and activates the expression of HapR which further down-regulates the virulence genes expression (Waters et al, 2008 ; Hema et al, 2015a ).…”
Section: Introductionmentioning
confidence: 99%