Intangible cultural heritage (ICH) is humanity’s mutual treasure; the history and civilization of humans are preserved in ICH. In particular, the protection of national ICH has become a principal focus of the Chinese government’s current active promotion of digital protection and innovative ICH development. Since ancient times, the Yangtze Delta region in China has been known as the “country of honey and milk”, and it remains home to many priceless historical and cultural artifacts. This paper combines the Geodetector tool and GIS spatial analysis in order to study as an example the spatial distribution pattern of national ICH in the Yangtze Delta region. The study demonstrates that the quantity and type of structures of national ICH in various provinces and cities differ from one another in terms of spatial distribution characteristics. In general, the spatial agglomeration of ICH is significant, and the spatial divergence between regions is obvious, showing a pattern of spatial distribution characterized by agglomeration in the southeast of the Yangtze Delta region and dispersion in the northwest, presenting different degrees and scales of distribution into groups and bands across each province and city. The indicators of different dimensions were discretized in ArcGIS, then entered into the Geodetector software. The results show that government support is the leading force in promoting the development of ICH, with scores of 0.630 and 0.597 for the secondary indexes. Social humanity serves as an important condition for the development of ICH, and the scores for the relevant secondary indexes were 0.461 and 0.146. Economic development provides the material basis for the further development of ICH, and the scores for these secondary indexes were 0.175 and 0.266. The natural environment determines the basic pattern of the spatial distribution of ICH, and the scores of the relevant secondary indexes in this case were 0.196 and 0.081. The results prove our hypothesis that government support is a core element. Interactions among the factors enhanced their influence on the spatial distribution of ICH. In addition, based on the exploration of the spatial structure of ICH, this research also provides several suggestions for the inheritance and development of ICH in the Yangtze Delta region and puts forward proposals for a future research agenda.