Medial Prefrontal-Hippocampal Connectivity and Motor Memory Consolidation in Depression and Schizophrenia

Genzel, Lisa; Dresler, Martin; Cornu, Marion; Jäger, Eugen; Konrad, Boris N.; Adamczyk, Marek; Frieß, Elisabeth; Steiger, Axel; Czisch, Michael; Goya-Maldonado, Roberto

doi:10.1016/j.biopsych.2014.06.004

Cited by 105 publications

(90 citation statements)

References 58 publications

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“…Our findings showed that SCZ patients had mainly altered FC with bilateral cerebellum posterior lobe, anterior and middle cingulate cortex, precuneus, and frontal-temporal system at baseline and follow-up, which align with the most common finding in the literature [25,26], indicating decreased FC between the left hippocampus and bilateral precuneus [27], the abnormal FC degree of hippocampal-prefrontal cortex during a sequential finger-tapping task [25], reduced FC between the hippocampus and distributed brain regions in SCZ patients [24]. Furthermore, numerous diffusion tensor image (DTI) studies have also indicated a disruption of neuronal fibers between the left posterior hippocampus and the PCC [28], and there are these reductions of the anatomical connectivity between the hippocampus and other regions [13].…”

Section: Discussionsupporting

confidence: 92%

A longitudinal study on intrinsic connectivity of hippocampus associated with positive symptom in first-episode schizophrenia

Duan¹,

Gan²,

Yang³

et al. 2015

Behavioural Brain Research

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Section: Discussionsupporting

confidence: 92%

A longitudinal study on intrinsic connectivity of hippocampus associated with positive symptom in first-episode schizophrenia

Duan¹,

Gan²,

Yang³

et al. 2015

Behavioural Brain Research

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“…In healthy individuals, significant performance improvements occur after sleep but not after wake (49, 93-95) and correlate with N2 duration (49) and spindle density (50, 96, 97). In contrast, chronic medicated SZ patients fail to show significant sleep-dependent improvement despite normal learning during training (31, 73, 98-100) and this failure correlated with sleep spindle density in one study (31), but not in two others (73, 100). SZ patients also show reduced sleep-dependent consolidation on a mirror tracing procedural motor task despite intact initial learning.…”

Section: Reduced Spindles Are Associated With Impaired Cognition and mentioning

confidence: 86%

Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?

Manoach

Pan

Purcell

et al. 2016

Biological Psychiatry

190

155

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Although schizophrenia is defined by waking phenomena, abnormal sleep is a common feature. In particular, there is accumulating evidence of a sleep spindle deficit. Sleep spindles, a defining thalamocortical oscillation of non-rapid eye movement Stage 2 sleep, correlate with IQ and are thought to promote long-term potentiation and enhance memory consolidation. Here we review evidence that reduced spindle activity in schizophrenia is an endophenotype that impairs sleep-dependent memory consolidation, contributes to symptoms and is a novel treatment biomarker. Studies showing that spindles can be pharmacologically enhanced in schizophrenia and that increasing spindles improves memory in healthy individuals suggest that treating spindle deficits in schizophrenia may improve cognition. Spindle activity is highly heritable and recent large-scale genome-wide association studies have identified schizophrenia risk genes that may contribute to spindle deficits and illuminate their mechanisms. For example, the schizophrenia risk gene CACNA1I encodes a calcium channel that is abundantly expressed in the thalamic spindle generator and plays a critical role in spindle activity in a mouse knockout. Future genetic studies of animals and humans can delineate the role of this and other genes in spindles. Such cross-disciplinary research, by forging empirical links in causal chains from risk genes to proteins and cellular functions, through to endophenotypes, cognitive impairments, symptoms and diagnosis, has the potential to advance the mechanistic understanding, treatment and prevention of schizophrenia. This review highlights the importance of deficient sleep-dependent memory consolidation among the cognitive deficits of schizophrenia and implicates reduced sleep spindles as a potentially treatable mechanism.

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“…Recent work places deficient sleep-dependent memory consolidation among the cognitive deficits of schizophrenia and implicates reduced sleep spindles, a defining electroencephalographic (EEG) feature of Stage 2 non-rapid eye movement sleep (N2), as a potentially treatable mechanism 4 . Schizophrenia patients have deficient sleep-dependent consolidation of both procedural [5][6][7][8][9][10] and declarative 11 memory that, in some studies, correlates with reduced sleep spindle density (spindles per minute) and number 10,11 . These relations are consistent with a large basic literature showing that spindle activity correlates with measures of intelligence and sleep-dependent memory consolidation 12 .…”

Section: Introductionmentioning

confidence: 99%

Coordination of Slow Waves With Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia

Demanuele

Bartsch

Baran

et al. 2016

Sleep

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Demanuele et al., 2016 1 This study is not a clinical trial. Demanuele et al., 2016 3 Coordination of Slow Waves with Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia AbstractStudy Objectives: Schizophrenia patients have correlated deficits in sleep spindle density and sleep-dependent memory consolidation. In addition to spindle density, memory consolidation is thought to rely on the precise temporal coordination of spindles with slow waves (SWs). We investigated whether this coordination is intact in schizophrenia and its relation to motor procedural memory consolidation.Methods: Twenty-one chronic medicated schizophrenia patients and 17 demographicallymatched healthy controls underwent two nights of polysomnography with training on the finger tapping motor sequence task (MST) on the second night and testing the following morning. We detected SWs (0.5-4Hz) and spindles during non-rapid eye-movement (NREM) sleep. We measured SW-spindle phase-amplitude coupling and its relation with overnight improvement of MST performance.Results: Patients did not differ from controls in the timing of SW-spindle coupling. In both groups spindles peaked during the SW upstate. For patients only, the later in the SW upstate that spindles peaked and the more reliable this phase relationship, the greater the overnight MST improvement.Regression models that included both spindle density and SW-spindle coordination predicted overnight improvement significantly better than either parameter alone suggesting that both contribute to memory consolidation.Conclusions: Schizophrenia patients show intact spindle-SW temporal coordination and these timing relationships, together with spindle density, predict sleep-dependent memory consolidation.These relations were seen only in patients suggesting that their memory is more dependent on optimal spindle-SW timing, possibly due to reduced spindle density. Interventions to improve memory may need to both increase spindle density and optimize the coordination of NREM oscillations.

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Medial Prefrontal-Hippocampal Connectivity and Motor Memory Consolidation in Depression and Schizophrenia

Abstract: While both patient groups showed similar deficits in consolidation associated with hippocampal-prefrontal cortex connectivity, other activity patterns more specific for disease pathology differed.

Cited by 105 publications

References 58 publications

A longitudinal study on intrinsic connectivity of hippocampus associated with positive symptom in first-episode schizophrenia

A longitudinal study on intrinsic connectivity of hippocampus associated with positive symptom in first-episode schizophrenia

Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?

Coordination of Slow Waves With Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia

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