Medial Preoptic Lesions and Male Sexual Behavior: Age and Environmental Interactions

Twiggs, Dennis G.; Popolow, Herbert B.; Gerall, Arnold A.

doi:10.1126/science.663624

Cited by 57 publications

(31 citation statements)

References 11 publications

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“…Thus, it would be important to examine a broader swath of the adolescent/pubertal period for individuals with adverse early life histories that may impact peer-related stressors during the teen years. Nonetheless, there is evidence in animal models that corrective social experiences in the pubertal period can reverse effects of early insults to the HPA axis (Twiggs, Popolow, & Gerall, 1978). …”

Section: Discussionmentioning

confidence: 99%

The confluence of adverse early experience and puberty on the cortisol awakening response

Quevedo

Johnson

Loman

et al. 2011

International Journal of Behavioral Development

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Associations between early deprivation/neglect in the form of institutional care with the cortisol awakening response (CAR) were examined as a function of pubertal status among 12- and 13-year-old post-institutionalized youth. CARs indexed hypothalamic-pituitary-adrenocortical reactivity. Post-institutionalized youth were compared to youth adopted internationally from foster care (adoption control) and to nonadopted youth reared in families comparable in parental education and income to the adoptive families. Post-institutionalized youth exhibited a blunted CAR if they were at earlier but not if they were at later stages of puberty. Similarly, for both groups of internationally adopted youth combined, earlier but not later stages of puberty were associated with more blunted CARs at higher but not lower levels of parent-reported pre-adoption physical and social neglect.

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Section: Discussionmentioning

confidence: 99%

The confluence of adverse early experience and puberty on the cortisol awakening response

Quevedo

Johnson

Loman

et al. 2011

International Journal of Behavioral Development

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“…That is, the dramatic changes in physiology and neurobehavioral function during adolescence may make an individual extremely susceptible to perturbations (Andersen, 2003;Dahl, 2004), but these striking transitions may also afford an important opportunity to intervene and combat these perturbations. There does appear to be experimental support for this assertion such that exposure to an enriching environment during adolescence can offset many of the negative neurobehavioral and physiological consequences of early life adversity (Bredy, Humpartzoomian, Cain, & Meaney, 2003;Bredy, Zhang, Grant, Diorio, & Meaney, 2004;Francis, Diorio, Plotsky, & Meaney, 2002;Laviola et al, 2004;Morley-Fletcher, Rea, Maccari, & Laviola, 2003), including brain damage (Twiggs, Popolow, & Gerall, 1978). Though it remains to be established whether it is necessary for these interventions to occur during adolescence to be most effective, these data do suggest that a window of opportunity exists for interventions during this crucial period of development.…”

Section: Adolescence: a Perfect Time For Intervetion?mentioning

confidence: 98%

Adolescence: A central event in shaping stress reactivity

Romeo

2010

Developmental Psychobiology

267

211

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ABSTRACT:The magnitude and duration of the hormonal stress response change dramatically throughout an organism's lifespan. Although much is known about the factors that modulate stress reactivity during adulthood and how neonatal development and aging influence stress responsiveness, we know relatively little about how stress reactivity changes during the juvenile to adult transition. Recent studies in adolescent boys and girls have suggested that stress is an important factor contributing to an individual's vulnerability to various neuropsychological dysfunctions, including anxiety, depression, and drug abuse. Thus, understanding how exposure to stressors during this crucial period of development lead to negative consequences is of paramount importance. A growing body of literature indicates that pubertal organisms react differentially, both physiologically and behaviorally, to a stressor compared to adults. The purpose of this review, therefore, is to discuss the recent findings regarding the pubertal maturation of stress reactivity, while also highlighting future research directions that will aid in our understanding of stress and adolescent mental health and development. ß 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 244-253, 2010.

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“…Indeed, it has been shown that lesions of the hypothalamic medial preoptic area have a deleterious effect on copulation in males of many species, including fish [Macey et al, 1974], lizards [Wheeler and Crews, 1978], birds [Balthazart and Surlemont, 1990], rats [Larsson and Heimer, 1964;Twiggs et al, 1978], dogs [Hart, 1974], and monkeys [Slimp et al, 1978]. Further, electrical stimulation of the same area has been found to have a facilitatory effect on this biological function [Malsbury, 1971].…”

Section: Introductionmentioning

confidence: 97%

Areas of brain activation in males and females during viewing of erotic film excerpts

Karama

Lecours

Leroux

et al. 2002

Human Brain Mapping

470

131

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Various lines of evidence indicate that men generally experience greater sexual arousal (SA) to erotic stimuli than women. Yet, little is known regarding the neurobiological processes underlying such a gender difference. To investigate this issue, functional magnetic resonance imaging was used to compare the neural correlates of SA in 20 male and 20 female subjects. Brain activity was measured while male and female subjects were viewing erotic film excerpts. Results showed that the level of perceived SA was significantly higher in male than in female subjects. When compared to viewing emotionally neutral film excerpts, viewing erotic film excerpts was associated, for both genders, with bilateral blood oxygen level dependent (BOLD) signal increases in the anterior cingulate, medial prefrontal, orbitofrontal, insular, and occipitotemporal cortices, as well as in the amygdala and the ventral striatum. Only for the group of male subjects was there evidence of a significant activation of the thalamus and hypothalamus, a sexually dimorphic area of the brain known to play a pivotal role in physiological arousal and sexual behavior. When directly compared between genders, hypothalamic activation was found to be significantly greater in male subjects. Furthermore, for male subjects only, the magnitude of hypothalamic activation was positively correlated with reported levels of SA. These findings reveal the existence of similarities and dissimilarities in the way the brain of both genders responds to erotic stimuli. They further suggest that the greater SA generally experienced by men, when viewing erotica, may be related to the functional gender difference found here with respect to the hypothalamus.

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Medial Preoptic Lesions and Male Sexual Behavior: Age and Environmental Interactions

Cited by 57 publications

References 11 publications

The confluence of adverse early experience and puberty on the cortisol awakening response

The confluence of adverse early experience and puberty on the cortisol awakening response

Adolescence: A central event in shaping stress reactivity

Areas of brain activation in males and females during viewing of erotic film excerpts

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