Medial Temporal Lobe Atrophy is Related to Learning Strategy Changes in Amnestic Mild Cognitive Impairment

Zhang, Liling; Sun, Wenhao; Xing, Mengya; Wang, Yue; Zhang, Yuanyuan; Sun, Qingna; Cheng, Yan; Shi, Chuan; Zhang, Nan

doi:10.1017/s1355617719000353

Cited by 16 publications

(17 citation statements)

References 73 publications

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“…The differences in cognitive function, such as memory, executive function, and information processing speed, between patients with amnestic mild cognitive impairment (aMCI) and patients with vascular cognitive impairment‐no dementia, who are considered as subjects with potentially prodromal stages for AD and VaD, respectively, were demonstrated in our previous study 17 . Moreover, we also found obvious impairment in the semantic learning strategy, which was attributable to MTA but independent of executive dysfunction and subcortical WMH in patients with aMCI 18 . In the present study, we aimed to establish the neuropsychological characteristics of SIVD patients and to find an optimal cognitive marker for differentiating mild to moderate patients with SIVD and AD.…”

Section: Introductionsupporting

confidence: 59%

A neuropsychological profile and its correlation with neuroimaging markers in patients with subcortical ischaemic vascular dementia

Tian

Zhang

Liu

et al. 2023

Int J Geriat Psychiatry

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Objectives Cognitive and neuroimaging assessments are still the main clinical practice methods for screening and diagnosing vascular dementia (VaD) patients. This study aimed to establish the neuropsychological characteristics of mild‐to‐moderate subcortical ischaemic vascular dementia (SIVD) patients, find an optimal cognitive marker for differentiating them from Alzheimer's disease (AD) patients, and explore the correlation between cognitive function and total small vessel disease (SVD) burden. Methods SIVD (n = 60) and AD (n = 30) patients and cognitively unimpaired healthy controls (HCs; n = 30) were recruited from our longitudinal MRI AD and SIVD study (ChiCTR1900027943) and received a comprehensive neuropsychological assessment and a multimodal MRI scan. Cognitive performance and MRI SVD markers were compared between groups. Combined cognitive scores were established for differentiating between SIVD and AD patients. Correlations between cognitive function and total SVD scores were analysed in dementia patients. Results SIVD patients showed poorer performance in information processing speed and better performance in memory, language, and visuospatial function than AD patients, although all cognitive domains were impaired in both groups compared with HCs. Combined cognitive scores showed an area under the curve of 0.727 (95%CI 0.62–0.84, p < 0.001) for differentiating SIVD and AD patients. Auditory Verbal Learning Test recognition scores were negatively correlated with total SVD scores in SIVD patients. Conclusions Our results suggested that neuropsychological assessments, specifically combined tests including episodic memory, information processing speed, language and visuospatial ability, are useful in the clinical differentiation between SIVD and AD patients. Moreover, cognitive dysfunction was partly correlated with MRI SVD burden in SIVD patients.

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Section: Introductionsupporting

confidence: 59%

A neuropsychological profile and its correlation with neuroimaging markers in patients with subcortical ischaemic vascular dementia

Tian

Zhang

Liu

et al. 2023

Int J Geriat Psychiatry

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“…For instance, apart from learning, delayed recall, and recognition, semantic clustering ratio was also found to be decreased during learning and memory process in subjects with aMCI compared with healthy individuals and subjects with vascular cognitive impairment-no dementia in our previous study (Sun et al, 2016). Our group further revealed that the impaired semantic learning strategy of aMCI was attributable to medial temporal lobe atrophy, which is the early pathologically involved brain area in patients with AD (Zhang et al, 2019).…”

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confidence: 54%

Is semantic learning strategy an early clinical marker for amnestic mild cognitive impairment and Alzheimer’s disease?

Zhang

2019

Int. Psychogeriatr.

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“…SemC refers to a phenomenon by which individuals reorganize items based on a shared semantic feature and then consecutively recall the words based on their superordinate category during the recall process (Becker and Lim, 2003). We have previously observed that SemC was decreased in a learning and memory assessment in persons with amnestic mild cognitive impairment and further revealed that this decline was attributable to medial temporal lobe atrophy (Zhang et al, 2019), indicating that semantic learning strategies play an important role in episodic memory and could be a potential marker for the early diagnosis of AD. In addition to the medial temporal lobe, the prefrontal cortex has been suggested to be involved in the process of semantic clustering during coding and recall.…”

Section: Discussionmentioning

confidence: 99%

Effects of age, sex, and education on California Verbal Learning Test-II performance in a Chinese-speaking population

et al. 2022

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The California Verbal Learning Test-Second Edition (CVLT-II), is a commonly used tool to assess episodic memory. This study analyzed learning and memory characteristics in a cognitively healthy Chinese population, as well as the effects of age, sex and education on CVLT-II factors. In total, 246 healthy people aged 20–80 years and 29 persons with multiple sclerosis (MS) were included in this study and completed the CVLT-II. Factors including total learning, learning strategy, serial position effects, short-delay free and cued recall, long-delay free and cued recall, repetitions and intrusions during recall, hits and false positives of recognition, and total recognition discriminability were calculated. The effects of age, sex and education on these factors were analyzed using ANCOVA or independent two-sample t-tests and further confirmed by multiple regression analysis. The regression-based normative data were then computed by the equivalent scores method. Moreover, differences in learning and memory were compared between persons with MS and age-, sex- and education-matched healthy individuals. Most CVLT-II factors significantly differed between different age and education groups; in particular, better performance in total learning, recall, semantic clustering and recognition was observed in the younger and more educated groups than in the older and less educated groups. Male participants showed higher recency effect scores, more repetitions and fewer hits than female participants. Compared with healthy individuals, persons with MS showed extensive impairments in memory processes, such as learning, recall, learning strategy and recognition (p < 0.05). These findings indicated that verbal learning and memory were highly dependent on age and educational level but not strongly affected by sex. The CVLT-II effectively assesses episodic memory impairment in the Chinese-speaking population.

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Medial Temporal Lobe Atrophy is Related to Learning Strategy Changes in Amnestic Mild Cognitive Impairment

Cited by 16 publications

References 73 publications

A neuropsychological profile and its correlation with neuroimaging markers in patients with subcortical ischaemic vascular dementia

A neuropsychological profile and its correlation with neuroimaging markers in patients with subcortical ischaemic vascular dementia

Is semantic learning strategy an early clinical marker for amnestic mild cognitive impairment and Alzheimer’s disease?

Effects of age, sex, and education on California Verbal Learning Test-II performance in a Chinese-speaking population

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