2024
DOI: 10.1002/alz.13832
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Medial temporal lobe gray matter microstructure in preclinical Alzheimer's disease

Christopher Brown,
Sandhitsu Das,
Long Xie
et al.

Abstract: INTRODUCTIONTypical MRI measures of neurodegeneration have limited sensitivity in early disease stages. Diffusion MRI (dMRI) microstructural measures may allow for detection in preclinical stages.METHODSParticipants had dMRI and either beta‐amyloid PET or plasma biomarkers of Alzheimer's pathology within 18 months of MRI. Microstructure was measured in portions of the medial temporal lobe (MTL) with high neurofibrillary tangle (NFT) burden based on a previously developed post mortem 3D‐map. Regressions examine… Show more

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