Median Cleft of the Lower Lip Associated with Lip Pits and Cleft of the Lip and Palate

Congenital pits of the lower lip constitute a rare developmental malformation, transmitted by an autosomal dominant mode, with considerable heterogeneity as regards the expression of the disorder. They are present in van der Woude syndrome (VWS), in which clefts of the upper lip and/or palate are often observed. Literature related to the various parameters associated with and relevant to the disorder is extensive. The purpose of this review is to cover, synthesize and categorize the existing knowledge into distinct entities, in order to facilitate understanding of the aetiopathogenesis of the malformation, its clinical manifestations and histological features, the epidemiology of the syndromic situation and the fundamental approach to an integral differential diagnosis. Special emphasis is given to the rationale underlying the treatment modalities that have been suggested, and the necessity for appropriate genetic counselling, as the disorder shows a high affinity with clefts and a familial type of occurrence.

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Van der Woude syndrome: a review. Cardinal signs, epidemiology, associated features, differential diagnosis, expressivity, genetic counselling and treatment

Rizos¹

2004

The European Journal of Orthodontics

148

101

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Seventeen-Year Follow-Up of a Patient With Median Cleft of the Lower Lip, Mandible, and Tongue With Flexion Contracture: A Case Report

Ishii¹,

Ishii²,

Moriyama³

et al. 2002

The Cleft Palate-Craniofacial Journal

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Etiopathogenesis of Lip, Alveolar Process and Palate Clefts

Wójcicka¹,

Kobus²

2008

Polish Journal of Surgery

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Median Cleft of the Lower Lip Associated with Lip Pits and Cleft of the Lip and Palate

Abstract: From an etiological point of view, this combination of malformations could have happened during the late embryogenic period. Why this combination is uncommon is not known.

Cited by 3 publications

References 6 publications

Van der Woude syndrome: a review. Cardinal signs, epidemiology, associated features, differential diagnosis, expressivity, genetic counselling and treatment

Van der Woude syndrome: a review. Cardinal signs, epidemiology, associated features, differential diagnosis, expressivity, genetic counselling and treatment

Seventeen-Year Follow-Up of a Patient With Median Cleft of the Lower Lip, Mandible, and Tongue With Flexion Contracture: A Case Report

Etiopathogenesis of Lip, Alveolar Process and Palate Clefts

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