Mediastinal hibernoma

Udwadia, ZarirF; Kumar, Nand; Bhaduri, Anita

doi:10.1016/s1010-7940(99)00051-2

Cited by 24 publications

(15 citation statements)

References 8 publications

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“…The peak incidence is in the third decade, and they usually arise in the natural distribution of brown fat: the scapular region, interscapular region, and upper thorax. At least four cases have been previously reported in the mediastinum [14][15][16][17]. A review of 170 cases from the Soft Tissue Registry of the Armed Forces Institute of Pathology reported 55 cases in the thigh [18].…”

Section: Discussionmentioning

confidence: 99%

Mediastinal hibernoma simulates a malignant lesion on dual time point FDG imaging

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Mediastinal hibernoma simulates a malignant lesion on dual time point FDG imaging

et al. 2008

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“…1 In the adult, brown fat is usually found in scattered foci as persisting vestigial remnants along the oesophagus, trachea, posterior neck, and interscapular area, and around the great vessels of the mediastinum. [2][3][4][5] Hence, hibernomas are usually seen at one of these sites, even though unusual sites have also been reported. 5 These tumours occur mostly in the third or fourth decade of life with no predominance of sex distribution.…”

Section: Discussionmentioning

confidence: 99%

Mediastinal hibernoma: a case report

Baldi

Santini²,

Mellone³

et al. 2004

J Clin Pathol

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Hibernomas are rare benign tumours that arise most often in adults from the remnants of fetal brown adipose tissue. They usually affect muscle and subcutaneous tissue and are asymptomatic and slow growing. The distribution of this tumour follows the sites of persistence of brown fat. Out of more then 100 cases described in the word literature only three hybernomas were mediastinal. A recent clinicopathological study of 170 cases from the Armed Forces Institute of Pathology confirmed the exceptionality of the intrathoracic location. This report describes a very rare case of mediastinal hibernoma in a young man.A 25 year old man was referred to the thoracic surgery department of the Second University of Naples (Italy) because of a left mediastinal mass, which was discovered on a routine pre-employment physical examination. The patient was completely asymptomatic. Physical examination and laboratory tests were non-contributory. A chest roentgenogram showed considerable enlargement of the mediastinum, involving particularly the left side of the chest ( fig 1A). Computed tomography showed a mixed density voluminous mass with well defined edges and nonhomogeneous density, involving predominantly the left part of the mediastinum (fig 1B). A thoracotomy was performed. A large, tan, lobulated, and encapsulated mass was found in the left mediastinum and was removed completely.The excised tumour specimen was fixed in 10% buffered formalin and paraffin wax embedded. Sections of 5 mm thickness were stained with haematoxylin and eosin, haematoxylin-van Gieson, and periodic acid Schiff-haematoxylin. Other sections were immunohistochemically stained using the standard avidin-biotin peroxidase complex method with S-100 antibody (Dako Corporation, Glostrup, Denmark). Diaminobenzidine was used as final chromogen and haematoxylin as nuclear counterstain. Negative controls were obtained by omitting the primary antibodies.Light microscopic examination revealed a tumour divided into numerous lobules by well vascularised connective tissue (fig 2A). The tumour cells were round or polygonal, multivacuolated with centrally placed nuclei resembling lipoblasts. Immunohistochemically, the cytoplasm of these cells was stained for S-100 protein ( fig 2B). Univacuolated cells with eccentrically placed nuclei resembling mature lipocytes were also present. A delicate fibrocollagenous and vascular capsule was present.These macroscopic and microscopic findings were suggestive of a mediastinal hibernoma. The patient made an uneventful recovery and after a five year follow up period there has been no recurrence.

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“…Intrathoracic cases reported from 2002 on are listed in Table 1. Tumours involving pleural locations as our two cases are extremely uncommon [5,6].…”

Section: Discussionmentioning

confidence: 61%

“…Various hypotheses are put forward to explain the origin of hibernoma at those sites where brown fat is not present in adults. These tumours may arise from aberrant differentiation of mesenchyma cells or by ectopic growth or migration of adipose tissue [5]. Less than 20 cases of intrathoracic hibernoma were described in world literature.…”

Section: Discussionmentioning

confidence: 99%