Mediastinal intraoperative radioisotope sentinel lymph node mapping in non-small-cell lung cancer

Atinkaya, Cansel; Küçük, N.; Koparal, Hakan; Araş, Gülseren; Sak, Serpil Dizbay; Özdemır, Nezıh

doi:10.1097/01.mnm.0000169381.99894.2f

Cited by 13 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite this limitation, advances in CLI technology and techniques continue to be made not only for diagnostic imaging but also for image-guided drug delivery and intra-operative guidance [42][43][44][65][66][67][68][69][70]. Currently multi-modal systems exist to detect malignancy though optical and radiometric detection [71][72][73][74]. As technologies and techniques are refined in this research area, it is entirely plausible that radiometric and CLI-enhanced detection have a role in providing intra-operative guidance within the context of neuroepithelia tumor resection.…”

Section: Discussionmentioning

confidence: 99%

Imaging of Fibroblast Activation Protein Alpha Expression in a Preclinical Mouse Model of Glioma Using Positron Emission Tomography

et al. 2020

View full text Add to dashboard Cite

Glioblastoma multiforme (GBM) is the most aggressive glioma of the primary central nervous system. Due to the lack of effective treatment options, the prognosis for patients remains bleak. Fibroblast activation protein alpha (FAP), a 170 kDa type II transmembrane serine protease was observed to be expressed on glioma cells and within the glioma tumor microenvironment. To understand the utility of targeting FAP in this tumor type, the immuno-PET radiopharmaceutical [89Zr]Zr-Df-Bz-F19 mAb was prepared and Lindmo analysis was used for its in vitro evaluation using the U87MG cell line, which expresses FAP endogenously. Lindmo analysis revealed an association constant (Ka) of 10−8 M−1 and an immunoreactivity of 52%. Biodistribution studies in U87MG tumor-bearing mice revealed increasing radiotracer retention in tumors over time, leading to average tumor-to-muscle ratios of 3.1, 7.3, 7.2, and 8.3 at 2, 24, 48 and 72 h, respectively. Small animal PET corroborated the biodistribution studies; tumor-to-muscle ratios at 2, 24, 48, and 72 h were 2.0, 5.0, 6.1 and 7.8, respectively. Autoradiography demonstrated accumulated activity throughout the interior of FAP+ tumors, while sequential tumor sections stained positively for FAP expression. Conversely, FAP− tissues retained minimal radioactivity and were negative for FAP expression by immunohistochemistry. These results demonstrate FAP as a promising biomarker that may be exploited to diagnose and potentially treat GBM and other neuroepithelial cancers.

show abstract

Section: Discussionmentioning

confidence: 99%

Imaging of Fibroblast Activation Protein Alpha Expression in a Preclinical Mouse Model of Glioma Using Positron Emission Tomography

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The prevalence of skip metastases in patients with non-small cell lung cancer (NSCLC) varies: 13% accordingly to Tanaka et al (Tanaka et al, 2004), 15% accordingly to Rzyman et al (Rzyman, 2006), 18% accordingly to Libshitz et al (Libshitz et al, 1986), 21% accordingly to Lardinois et al (Lardinois et al, 2003), and 25% accordingly to Soltesz et al (Soltesz et al, 2005). Other authors found a even higher prevalence of N2 disease without compromise of hilar nodes (28.5-37.8%) (Tateishi et al, 1994;Yoshino et al, 1996;Prenzel et al, 2003;Misthos et al, 2004, Atinkaya et al, 2005.…”

Section: Introductionmentioning

confidence: 92%

The problem of direct lymph drainage of the bronchopulmonary segments into the mediastinal and hilar lymph nodes

Topol

Masłoń

2009

Clinical Anatomy

View full text Add to dashboard Cite

The phenomenon of skip metastases depends on the occurrence of direct metastases of non-small cell lung cancer into mediastinal lymph nodes without the involvement of hilar lymph nodes. The medical literature suggests that this prevalence ranges between 13 and 37.8% of cases. The goal of our study was to evaluate the prevalence of subpleural superficial lymphatic vessels carrying the lymph from the bronchopulmonary segments directly to the mediastinal nodes thus skipping the hilar nodes and determine whether there is a tendency towards differentiation in lymph drainage between males and females. During autopsy, 27 left and 27 right lungs were removed from 19 male and eight female cadavers. The lymphatic vessels were visualized at the mediastinal and interlobar surface of the lung by visual inspection. These vessels were then cannulated and injected with drawing ink. The first lymph node to become ink-colored via injection was dissected and histologically examined. The lymph flowed into hilar lymph nodes in 79.5% of the cases and into the mediastinal nodes in 20.5% of all the 83 vessels injected; of these 13.2% were from the right lung and in 7.2% from the left lung. The upper right lobe (5/14 vessels) and its anterior segment (3/14 vessels) were the most common source of the direct lymph drainage to the mediastinum. Vessels of 15.4% in female cadavers (4/26) and 22.8% vessels in male cadavers (13/57) traveled directly to mediastinal nodes skipping the hilar nodes. This difference was not statistically significant.

show abstract

Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Leong

Zuber

Ferris

et al. 2011

Journal of Surgical Oncology

View full text Add to dashboard Cite

The validation of sentinel lymph node (SLN) concept in melanoma and breast cancer has established a new paradigm in cancer metastasis that, in general, cancer cells spread in a orderly fashion from the primary site to the SLNs in the regional nodal basin and then to the distant sites. In this review article, we examine the development of SLN concept in penile carcinoma, melanoma and breast carcinoma and its application to other solid cancers with emphasis of the relationship between micrometastasis in SLNs and clinical outcomes.

show abstract

Mediastinal intraoperative radioisotope sentinel lymph node mapping in non-small-cell lung cancer

Abstract: These results demonstrate the feasibility of this procedure in identifying the first site of potential nodal metastasis of NSCLC. This method may improve the precision of pathological staging.

Cited by 13 publications

References 24 publications

Imaging of Fibroblast Activation Protein Alpha Expression in a Preclinical Mouse Model of Glioma Using Positron Emission Tomography

Imaging of Fibroblast Activation Protein Alpha Expression in a Preclinical Mouse Model of Glioma Using Positron Emission Tomography

The problem of direct lymph drainage of the bronchopulmonary segments into the mediastinal and hilar lymph nodes

Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Contact Info

Product

Resources

About