Mediastinal Liposarcoma

Wiedemann, Dominik; Schistek, R; Gassner, Eva; Antretter, Herwig

doi:10.1111/j.1540-8191.2010.01174.x

Cited by 3 publications

(2 citation statements)

References 7 publications

(10 reference statements)

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“…Total surgical resection whenever possible seems reason-able. 53 In one-third of all reported cases (35.8%) only subtotal resection was possible, with a significantly decreased 1-year survival rate (41.7% vs. 89.5%; p ¼ 0.002). In less than 50% of included case reports, adjuvant chemotherapy or radiation is mentioned.…”

Section: Discussionmentioning

confidence: 94%

Cardiac Liposarcoma—A Review of Outcome after Surgical Resection

Deppe

Adler

Madershahian

et al. 2013

Thorac cardiovasc Surg

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Section: Discussionmentioning

confidence: 94%

Cardiac Liposarcoma—A Review of Outcome after Surgical Resection

Deppe

Adler

Madershahian

et al. 2013

Thorac cardiovasc Surg

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“…Current recommendation in treatment for liposarcoma is en bloc removal if possible, as this is the only definitive treatment option 4. As well as the other soft tissue sarcomas, local control is critical and largely depends on the quality of surgery 5.…”

Section: Discussionmentioning

confidence: 99%

Giant liposarcoma of the posterior mediastinum and retroperitoneum

Taki

Watanabe²,

Iwagami³

et al. 2011

Case Reports

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Liposarcomas of the Mediastinum and Thorax

Boland

Colby

Folpe

2012

American Journal of Surgical Pathology

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Liposarcoma rarely occurs in the mediastinum, and most reports predate the current genetically based classification system. We report the clinicopathologic and molecular genetic features of a series of thoracic liposarcomas identified over a 60-year period. Twenty-four confirmed cases were reclassified using the most recent World Health Organization classification. Fluorescent in situ hybridization for CPM amplification and/or DDIT3 rearrangement was performed on selected cases. The 24 cases occurred in 13 men and 11 women (mean age, 53 y; range, 15 to 73 y) and arose in all mediastinal compartments. All subtypes were encountered with 8 well-differentiated liposarcomas, 6 dedifferentiated liposarcomas (3 of 6 confirmed CPM+), 7 pleomorphic liposarcomas (2 of 7 confirmed CPM-, 1 of 7 confirmed DDIT3-), 2 myxoid liposarcomas, and 1 unclassifiable liposarcoma (CPM- and DDIT3-). Unusual histologic features included myxoid well-differentiated liposarcoma mimicking myxoid liposarcoma (2 cases), lipoleiomyosarcoma (1 case), dedifferentiated liposarcoma with "meningothelial"-like dedifferentiation, differentiated myxoid liposarcoma mimicking well-differentiated liposarcoma (CPM-), and pleomorphic liposarcoma with epithelioid and myxoid change. Follow-up information was available for 19 patients (mean, 55 mo; range, 8 to 252 mo). Outcome was strongly associated with histologic subtype, with death from disease occurring in 1 of 6 well-differentiated, 1 of 4 dedifferentiated, 5 of 7 pleomorphic, and 2 of 2 myxoid liposarcomas. The mediastinum shows a preponderance of uncommon subtypes and unusual morphologic variants. Correct classification has important implications, with most patients with well-differentiated/dedifferentiated liposarcoma having a protracted clinical course, in contrast to the more rapid disease progression seen in patients with myxoid and pleomorphic liposarcoma.

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Mediastinal Liposarcoma

Abstract: A 64-year-old male underwent surgical resection of a large liposarcoma of the mediastinum. The management of this unusual tumor is the subject of this case report.

Cited by 3 publications

References 7 publications

Cardiac Liposarcoma—A Review of Outcome after Surgical Resection

Cardiac Liposarcoma—A Review of Outcome after Surgical Resection

Giant liposarcoma of the posterior mediastinum and retroperitoneum

Liposarcomas of the Mediastinum and Thorax

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