Mediastinal malignant fibrous histiocytoma developing from a foreign body granuloma

Abstract

A patient with mediastinal malignant fibrous histiocytoma (MFH) apparently developing from a foreign body granuloma is reported. A 72-year-old man was admitted to our hospital complaining of generalized fatigue and palpitations. He had undergone surgery for pulmonary tuberculosis 46 years previously. Radiography and computed tomography of the chest showed a round 5-cm mass with marginal calcification in the right side of the anterior mediastinum. The mass was resected completely via median sternotomy. Intraoperative diagnosis of foreign body granuloma was made, based on gauze fragments found in the mass and intraoperative pathologic findings suggesting benign granulation tissue. The postoperative histopathologic diagnosis was myxoid MFH. To our knowledge, mediastinal MFH developing from a foreign body granuloma has not been reported previously.

Primary Malignant Fibrous Histiocytoma in Mediastinum: Imaging with 18F-FDG PET/CT

“…In the present case, MFH was mainly located in the superior mediastinum, extending to the anterior, middle mediastinum and the lower neck. Most MFHs developed de novo; however, several cases were associated with radiation therapy [10] or previous operation procedures [11]. Our patient had no previous operation and radiation therapy.…”

Retained Surgical Gauze Swab Migration in a Paraplegic Patient: A Case Report and Literature Review

“…Rajkovi, et al described a case of gossypiboma discovered 40 years after index surgery as the cause for chronic lumbar back pain [6]. As a consequence of the inflammatory process introduced by retained surgical bodies, sarcomas developing from chronic inflammatory tissue have been reported throughout the literature [10][11][12]. In the presented case, the exudative process led to migration of surgical gauze to the distal medial thigh over a period of 15 years.…”

A new complication of retained surgical gauze: development of malignant fibrous histiocytoma – report of a case with a literature review

“…Concerning foreign bodies, retained surgical gauze (RSG)-induced MFH has been reported in only one case [2]. In this report, the site of the tumor was the thorax, whereas development of MFH in the abdomen, in association with RSG, has never been reported.…”

“…However, reporting a cancer development as a complication of textiloma is limited to only one case [2]. To our knowledge, this is the second report of malignant transformation at the site of a RSG in a man and the first report of a primary intra-abdominal MFH arising around a textiloma.…”

“…Fortunately, this phenomenon is uncommon in humans. Only a few reports describe the development of tumors in association with foreign bodies, and in most of them, the tumor is a malignant fibrous histiocytoma (MFH) [2-4]. …”