Mediastinal myxopapillary ependymoma primary or late metastases of paracoccygeal ependymoma: a case report

Satti, Mohamed B.; Firoze, Mohamed; Malaker, K.; Hussain, Mohammed A.; Maniyar, Iqbal H.

doi:10.1016/j.anndiagpath.2005.04.015

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…Occasionally, they occur at other central nervous system (CNS) locations including the cervical and thoracic spinal cord, the fourth ventricle, the lateral ventricles and the brain parenchyma . Less commonly, they have been reported to occur in the absence of a previous or concomitant spinal cord MPE, at sites including the subcutaneous sacrococcygeal region, presacral region and mediastinum, possibly arising from ectopic ependymal rests .…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic features of anaplastic myxopapillary ependymomas

et al. 2019

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Myxopapillary ependymomas (MPE) are considered benign (World Health Organization (WHO) grade I) neoplasms with favorable prognosis. However, malignant behavior occurs in a small subset. To our knowledge, only five anaplastic MPEs have been reported without consensus on diagnostic criteria. We retrieved 14 anaplastic MPEs from the pathology archives of six institutions. Each tumor included at least two of the following features: ≥5 mitoses per 10 high power fields, Ki-67 labeling index (LI) ≥10%, microvascular proliferation (MVP) and spontaneous necrosis. These features were typically encountered in the foci of hypercellularity and reduced mucin. There were eight male and six female patients (age range 6-57 years, median = 16.5). Ten tumors displayed anaplasia at initial resection, and 4 were anaplastic at a second surgery for recurrence (ranging from 9 months to 14 years following initial resection). The Ki-67 LI ranged between 8% and 40% in the anaplastic foci and <3% in the foci of classic MPE. There was documented cerebrospinal fluid (CSF) dissemination in seven cases, recurrence following an anaplastic diagnosis in three cases and bone or soft tissue invasion in two cases. One patient suffered lung metastases. Two cases evaluated by targeted next-generation sequencing and one evaluated by fluorescence in situ hybridization (FISH) showed nonspecific chromosomal gains. We conclude that although rare, anaplastic MPE occurs in both pediatric and adult patients, similar to other ependymomas. At a minimum, closer follow-up is recommended, given the concern for aggressive biologic potential. Further study is needed to determine WHO grading criteria and genetic indicators of tumor progression.

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Section: Introductionmentioning

confidence: 99%

Clinicopathologic features of anaplastic myxopapillary ependymomas

et al. 2019

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“…MPEs are characterized by a subcutaneous location in the sacrococcygeal area or presacral region without any connection to the spinal cord. Several cases of primary ependymomas located in other organs—mediastinum, 5 ovaries, 6,7 lung, 7 breast, 7 and uterine ligaments 8 —have also been reported in the literature. According to previous studies, extra-axial ependymomas tend to metastasize, regardless of the histological grade.…”

Section: Introductionmentioning

confidence: 99%

Myxopapillary Ependymoma of Lumbar Soft Tissue: A Case Report With Gene Expression Evaluation

et al. 2017

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Primary extraspinal myxopapillary ependymoma (MPE) is an exceptionally rare lesion that is mainly located in the subcutaneous sacrococcygeal region. We describe the first case of MPE that presented as an intramuscular tumor mass located in the lumbar area. Absence of the visible connection with the spinal cord and lack of any other tumors in the reported case argue for the primary ectopic origin of the MPE. The differential diagnosis of MPE is discussed. Additionally, we evaluated the expression level of molecular biomarkers that have a prognostic value in central nervous system tumors.

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“…Rare examples of ependymomas involving the posterior mediastinum have been described ( 72 - 76 ). However, we have not seen any in our practice.…”

Section: Malignant Tumors Of Peripheral Nerve Originmentioning

confidence: 99%

Mediastinal tumors of peripheral nerve origin (so-called neurogenic tumors)

Marchevsky¹,

Balzer²

2020

Mediastinum

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The mediastinum can be the site of origin of a variety of benign and malignant tumors of peripheral nerve sheath origin. Although schwannoma is one of the most common tumors found in the posterior mediastinum, peripheral nerve sheath tumors are reported in all compartments of the mediastinum. The majority of peripheral nerve sheath tumors in the mediastinum as in other anatomic sites occur sporadically, and a subset of them, most notably neurofibromas, and to a lesser extent, schwannomas and malignant peripheral nerve sheath tumors, occur in patients with syndromes such as neurofibromatosis 1 (NF1). In this review, the characteristics of mediastinal nerve sheath tumors along with the histologic differential diagnosis are summarized. Primary emphasis is placed upon the use of morphologic criteria for establishing a definitive diagnosis with reference to photomicrographs to illustrate the classic and sometimes unusual features of this varied group of tumors. The judicious application of ancillary testing, most frequently immunohistochemistry, for separating peripheral nerve sheath tumors from each other and from their morphologic mimics is reviewed. Included in the review are the clinicopathologic features, clinical management and prognostic implications of benign and malignant mediastinal peripheral nerve sheath tumors.

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Mediastinal myxopapillary ependymoma primary or late metastases of paracoccygeal ependymoma: a case report

Cited by 6 publications

References 13 publications

Clinicopathologic features of anaplastic myxopapillary ependymomas

Clinicopathologic features of anaplastic myxopapillary ependymomas

Myxopapillary Ependymoma of Lumbar Soft Tissue: A Case Report With Gene Expression Evaluation

Mediastinal tumors of peripheral nerve origin (so-called neurogenic tumors)

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