Mediastinal parathyroid lipoadenoma as cause of primary hyperparathyroidism

Incidentally discovered parathyroid lipoadenoma in thyroid surgery: A case report and review of the literature

“…In addition, it has been reported in the literature that parathyroid lipoadenoma may account for a higher proportion in males than parathyroid adenoma 2 . The age of onset of parathyroid lipoadenomas varies from 24 to 88 years, mostly located in the neck, but up to 15% of parathyroid lipoadenomas are ectopic or located in the mediastinum, much higher than common parathyroid adenomas 3 …”

“…2 The age of onset of parathyroid lipoadenomas varies from 24 to 88 years, mostly located in the neck, but up to 15% of parathyroid lipoadenomas are ectopic or located in the mediastinum, much higher than common parathyroid adenomas. 3 In 1958, Ober and Kaiser 4 first described parathyroid lipoadenoma in a middle-aged man with a gradually enlarging neck mass that was painless and without manifestations of hyperparathyroidism. A large lipoma was found under the sternum on neck exploration.…”

“… 2 The age of onset of parathyroid lipoadenomas varies from 24 to 88 years, mostly located in the neck, but up to 15% of parathyroid lipoadenomas are ectopic or located in the mediastinum, much higher than common parathyroid adenomas. 3 …”

“…Primary hyperparathyroidism is most commonly caused by solitary parathyroid adenomas, accounting for more than 80%–85%; less commonly, parathyroid hyperplasia, parathyroid carcinoma, and multiple parathyroid adenomas. 3 Parathyroid lipoadenoma is a very rare cause of primary hyperparathyroidism with an incidence of 0.5%–1.6% of primary hyperparathyroidism. In parathyroid lipoadenomas, the sensitivity of imaging is significantly reduced by low parathyroid cell concentration and excessive fat content.…”

Incidentally discovered parathyroid lipoadenoma in thyroid surgery: a case report and review of the literature

“…Parathyroid lipoadenomas are rare and are incidentally detected during thyroid cancer surgery in this case. In this paper, 40 literatures with "parathyroid lipoademona" as search term on PubMed [1,2,4,5, and 65 cases of parathyroid lipoadenoma (including this case) were counted. After excluding 18 cases with missing clinical data, 47 cases had complete clinical data, including 30 females and 17 males, with a female-to-male ratio of about 1.8:1, that is, parathyroid lipoadenoma accounted for a higher proportion in females than in males.…”