Mediastinal Teratoma Associated With Klinefelter’s Syndrome

Klinefelter syndrome: Expanding the phenotype and identifying new research directions

“…Extragonadal germ cell cancer and mediastinal teratomas are increased; the latter is particularly striking, the frequency 34 to 40 times that of the general population. 39 One explanation invoked to explain the increased frequency of cancer in XXY is that constitutional chromosomal abnormalities and extragonadal aneuploid germ cells predispose to malignant degeneration. The analogy might be increased leukemia in Down syndrome and increased neoplasia in other sex chromosomal abnormalities.…”

Mediastinal Tumor and Klinefelter's Syndrome

“…The overall incidence of Klinefelter's syn drome is approximately 1 in 800 males. The incidence of chromatin positive (47,XXY) males with mediastinal germ cell tumors is 7.7% [1]. Besides mediastinal germ cell tumors, other tumors include pros tatic and lung carcinoma, breast cancer, reticulum cell sarcoma, chronic and acute myelogenous leukemia, and acute lymphoblastic leukemia.…”

Establishment and characterization of a prostatic small-cell carcinoma cell line (PSK-1) derived from a patient with Klinefelter syndrome

“…Tumors are mainly related to hormone-dependent tissues, such as male breast cancer [3] and extragonadal germ-cell tumor [4]. Male breast cancer and mediastinal germ-cell tumor have a 20-fold and 30-40-fold increased frequency in KS patients compared to the normal population, respectively [3,15]. However, the exact mechanism for the in- a Singly dispersed cells were plated in 60-mm plastic petri dishes and then cultured for 14 days at 37°C in a 5% CO 2 incubator.…”