Mediastinal Teratoma with Coexisting Adenocarcinoma and Carcinoid Tumor (Somatic-Type Malignancy): A Case Report with a Review of the Literature

Agarwal, Swati; Mullick, Shalini; Gupta, Kamali; Dewan, Ravindra Kumar

doi:10.5152/ttd.2014.4280

Cited by 9 publications

(9 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical decision of continuing with chemotherapy directed at the GCT component or at the SMT component is challenging and decided on a case-by-case basis, with different outcomes from series to series. 14,[41][42][43] Additional levels of complexity in this decision include the context of paediatric cancers, 41,44 SMT arising in ovarian GCTs, 45 and in extragonadal locations, [46][47][48][49][50] which are rarer but may have their own specificities.…”

Section: Discussionmentioning

confidence: 99%

Morphological spectrum and molecular features of somatic malignant transformation in germ cell tumours

et al. 2022

View full text Add to dashboard Cite

Aims Somatic malignant transformation (SMT) arising in germ cell tumours (GCTs) is an infrequent, but clinically relevant event. There is only limited knowledge on the morphological spectrum of SMT, and the therapeutic management of these patients is poorly defined. In this work we revisit two consecutive case series (n = 756) of GCTs. Clinicopathological data of SMTs arising in GCTs were determined, with a focus on the histopathological spectrum, and molecular aspects were obtained by Fluorescence in situ Hybridization (FISH) and Next Generation Sequencing (NGS). Methods and Results Thirty male patients (28 primary testicular, two primary extragonadal) were included. These patients represent 4% of GCT patients diagnosed at two institutes (University Hospital Zurich and IPO Porto). The most common SMTs were adenocarcinoma (n = 8), embryonic‐type neuroectodermal tumours (ENETs, n = 8), and rhabdomyosarcoma (n = 6), but a wide range of challenging morphologies were depicted, including low‐grade neuroglial tumour, adenosquamous carcinoma, neuroblastoma, and neuroendocrine carcinoma. SMT was found in 15 primary tumour samples and in 27 metastatic samples of these 30 patients, the latter showing poorer overall survival. Adenocarcinoma occurred only in metastasis postchemotherapy and in one primary retroperitoneal GCT with SMT, but not in GCT of the testis. The 12p gains were identified by FISH in all cases. NGS results were available in six patients. Clinical trials and/or targeted treatments based on the molecular profile of SMT were recommended in four patients. Conclusions SMT arising in GCTs represent a diagnostic challenge and should be confirmed by a specialized uropathologist. NGS‐based treatment recommendations may improve the outcome of these patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Morphological spectrum and molecular features of somatic malignant transformation in germ cell tumours

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Histologically, it seems that the malignant component is often carcinomatous (13,14) but this somatic-type only represents 37% of all GCTs with somatic-type malignancies (15). These tumours mostly always occur in males (12), between the ages of 20 to 40 years; however a few cases concerning females have been reported in the literature, mainly as case reports (14,(16)(17)(18)(19)(20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

“…These non-germ cell malignancies are postulated to originate either from totipotential germ cells differentiating to somatic type cells or from pre-existing mature teratoma elements to non-germ cell malignancy (14,20,22). Molecular studies have shown an isochromosome 12p (i[12p]) genotype with no clearly de ned consequence in carcinogenesis, that is shared by both the somatic-type malignancy and its associated germ cell tumor component (12).…”

Section: Discussionmentioning

confidence: 99%

Metastatic Adenocarcinoma to the Breast arising from a Mediastinal Mature Teratoma with Somatic Malignancy: A Case Report with a Review of the Literature

Arhant¹,

Mirdad²,

Berghian³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Malignant transformation in mature teratomas, especially somatic-type malignancies, are extremely rare phenomena with few cases described in the literature. In the mediastinum, these lesions are often accompanied by metastases, ultimately unmasking them. Case presentation We report an exceptional case of metastatic adenocarcinoma to the breast arising from a mediastinal mature teratoma with malignant transformation in a 31-year-old female. The patient initially presented with a breast lesion that was later diagnosed as either a triple negative ductal carcinoma or a metastatic adenocarcinoma of unknown origin. Extensive clinical workup and radiological imagining revealed an anterior mediastinal mass. Subsequent pathological examination of the mass showed a mature teratoma with malignant transformation equivalent to that found in the breast biopsy. Conclusion Mediastinal teratomas with malignant transformation (TMTs) are rare entities; however these tumors should be suspected in cases of suspicious mediastinal masses presenting with unusual clinical and radiological signs, such as metastasis of unknown primary origin. Pathological corroboration of extensive sampling and meticulous microscopic examination is crucial for the diagnosis in order to tailor subsequent treatment.

show abstract

“…[1617] A synchronous primary neuroendocrine tumor and primary adenocarcinoma arising within mature cystic teratoma is extremely rate, and only five cases have been reported [Table 2]. [1819202122] To the best of our knowledge, no prior report described a mature cystic teratoma in CS coexisting with both adenocarcinoma and NET.…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma and neuroendocrine tumor arising within presacral teratoma associated with Currarino syndrome: A case report

Chatani

Onaya

Kato

et al. 2019

Indian Journal of Radiology and Imaging

View full text Add to dashboard Cite

We present a case of a 59-year-old woman with a malignant tumor arising within presacral teratoma associated with Currarino syndrome (CS). A characteristic crescent-shaped sacrum was detected on preoperative image examination and the presacral mass was pathologically diagnosed as a malignant tumor associated with CS. To our knowledge, this is the first case report of presacral teratoma associated with CS coexisting with both adenocarcinoma and a neuroendocrine tumor.

show abstract

Mediastinal Teratoma with Coexisting Adenocarcinoma and Carcinoid Tumor (Somatic-Type Malignancy): A Case Report with a Review of the Literature

Cited by 9 publications

References 9 publications

Morphological spectrum and molecular features of somatic malignant transformation in germ cell tumours

Morphological spectrum and molecular features of somatic malignant transformation in germ cell tumours

Metastatic Adenocarcinoma to the Breast arising from a Mediastinal Mature Teratoma with Somatic Malignancy: A Case Report with a Review of the Literature

Adenocarcinoma and neuroendocrine tumor arising within presacral teratoma associated with Currarino syndrome: A case report

Contact Info

Product

Resources

About