Mediastinoscopy and Its Application: Thymectomy via the Suprasternal Notch

Yoshimatsu, Hiroshi; Ikeda, Takaaki; Tsuchiya, Masaharu; Shimabukuro, K

doi:10.2302/kjm.20.29

Cited by 18 publications

(2 citation statements)

References 9 publications

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“…culture supernates Thymus was obtained from a patient with myasthenia gravis using the method described by Yoshimatsu et al (1971). Thymic epithelial cultures were prepared as described previously (Mizuno et al, 1978).…”

Section: Source and Preparation Of Thymic Epithelial And Othermentioning

confidence: 99%

“…In this study, the effects of supernates of thymic epithelial cell culture (STEC)-derived from a patient with myasthenia gravis and thymosin fraction 5, a thymic humoral factor, or platelet aggregation induced by adenosine diphosphate (ADP) or thrombin and on the cyclic AMP levels in rabbit platelets were investigated. Source and preparation of thymic epithelial and other culture supernates Thymus was obtained from a patient with myasthenia gravis using the method described by Yoshimatsu et al (1971). Thymic epithelial cultures were prepared as described previously (Mizuno et al, 1978).…”

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confidence: 99%

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In vitro effect of a thymic epithelial culture supernate or thymosin fraction 5 on rabbit platelet aggregation and intracellular cyclic AMP levels

Hashimoto

Itoh

Kawaguchi

et al. 1987

Journal Cellular Physiology

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Supernates of thymic epithelial cell culture (STEC) strongly inhibit aggregation induced by addition of adenosine diphosphate (ADP: 1 microM) or thrombin (0.5 unit per ml) to washed platelet suspensions and accelerated the restoration from ADP-triggered aggregation. At the same time, STEC increased the level of platelet adenosine 3',5'-cyclic monophosphate (cyclic AMP) in a dose-dependent manner. Depending on the concentration used, thymosin fraction 5 increased the level of intracellular cyclic AMP ranging between 5 and 100 micrograms per ml, as well as inhibiting ADP-induced platelet aggregation. The activities of both STEC and thymosin fraction 5 were found to act exclusively on cyclic AMP phosphodiesterase activity in platelets. In contrast the supernates from Chang, HeLa, or HCC-M cells did not affect platelet aggregation induced by ADP, but slightly increased the cyclic AMP level (Chang, HeLa). Within 2 min after the treatment with STEC, more than 50% of the maximum inhibitory activity on platelet aggregation and increases in intracellular cyclic AMP were observed. These activities disappeared following STEC treatment with pronase E. STEC activity was found predominantly in the 1,000-50,000-dalton fractions. These activities were not altered when STEC was treated by adenosine deaminase. The level of prostaglandin E (PGE) derivatives in STEC was about two times that found in the control culture medium. These data suggest that the biological activity of STEC in the platelets might be attributed to thymosinlike polypeptides and PGE1.

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Section: Source and Preparation Of Thymic Epithelial And Othermentioning

confidence: 99%

mentioning

confidence: 99%

In vitro effect of a thymic epithelial culture supernate or thymosin fraction 5 on rabbit platelet aggregation and intracellular cyclic AMP levels

Hashimoto

Itoh

Kawaguchi

et al. 1987

Journal Cellular Physiology

Self Cite

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Prognosis in Occult Thymomas in Myasthenia Gravis Following Transcervical Thymectomy

Papatestas

Pozner²,

Genkins³

et al. 1987

Arch Surg

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Comparative, immunological studies on Lymphangiectasia of the small intestine revealed in protein losing gastroenteropathy and Behçet’s disease

et al. 1976

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Lymphangiectasia of the small intestine was demonstrated in 9 to 18 cases with protein losing gastroenteropathy and in 10 of 26 cases with Behçhet's disease. Protein losing gastroenteropathy was compared to Behçet's disease in view of immunological aspects. Immunoglobulin containing cells in the jejunal mucosa of protein losing gastroenteropathy were decreased, whereas Behçet's disease had normal or increased distribution. This suggested that suggested that immunoglobulin may be lost into the intestinal lumen or that production of those cells may be inhibited in protein losing gastroenteropathy. Decreased DNCB skin reaction and impaired blastoid transformation of peripheral lymphocytes in both of two diseases suggested that there should be immunological defect in those diseases. However, in Behçet's disease, investigation of the thymus disclosed hyperplasia and the presence of lymphoid follicle which does not appear in normal state. In conclusion, protein losing gastroenteropathy is in immunological deficiency state due to the congenital or acquired disorders of lymphatics which implies abnormal protein loss, decreased immunoglobulin containing cells in the jejunal mucosa and decreased sensitivity. On the contrary, in Behçet's disease hyperimmune state is present based on thymic hyperplasia.

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Mediastinoscopy and Its Application: Thymectomy via the Suprasternal Notch

Cited by 18 publications

References 9 publications

In vitro effect of a thymic epithelial culture supernate or thymosin fraction 5 on rabbit platelet aggregation and intracellular cyclic AMP levels

In vitro effect of a thymic epithelial culture supernate or thymosin fraction 5 on rabbit platelet aggregation and intracellular cyclic AMP levels

Prognosis in Occult Thymomas in Myasthenia Gravis Following Transcervical Thymectomy

Comparative, immunological studies on Lymphangiectasia of the small intestine revealed in protein losing gastroenteropathy and Behçet’s disease

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