Mediastinum primary small cell neuroendocrine carcinoma

Wang, Hong-Lu; Wu, Xiao; Zhu, Luyi

doi:10.5114/wo.2016.58505

Cited by 3 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Often, collateral venous circulation causes the distension of the superficial veins in the chest wall [7-8]. In one case report, the patient presented with chest distress, dizziness, and a red face and was found to have SVC syndrome secondary to primary MSCNC [2]. Our patient presented with SVC syndrome associated with facial swelling, facial redness, upper extremity swelling, dysphagia, and shortness of breath.…”

Section: Discussionmentioning

confidence: 91%

“…The diagnosis of MSCNC requires both pathological identification via biopsy revealing the characteristic organoid pattern of the tumor, as well as immunohistochemical positivity for the characteristic markers of MSCNC [2,9-11]. Chromogranin A and synaptophysin are currently considered the most specific immunohistochemical markers for neuroendocrine tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Chromogranin A and synaptophysin are currently considered the most specific immunohistochemical markers for neuroendocrine tumors. The basal panels of immunohistochemical markers, such as caudal type homeobox (CDX-2), ISL LIM homeobox 1 (ISL-1), TTF-1, and paired box 6/8 (PAX 6/8) are currently being used to identify neuroendocrine neoplasms [2,10]. A large tumor located in the anterior or middle mediastinum showing scattered punctate calcifications and compressing the adjacent mediastinal structures in the CT scan of the chest should raise suspicion for a small cell neuroendocrine carcinoma [11].…”

Section: Discussionmentioning

confidence: 99%

“…No clear guidelines for MSCN treatment have been established due to the rarity of the disease. Surgical treatment complemented with chemotherapy and radiotherapy might alleviate the MPSCN patients’ symptoms and prolong their survival [2]. The prognosis of patients with primary neuroendocrine tumors remains poor due to the frequency of local recurrence and metastasis after surgical excision.…”

Section: Discussionmentioning

confidence: 99%

“…These types of tumors are frequently discovered secondary to their compression of neighboring mediastinal structures [1]. Diagnosis requires both pathological identification via biopsy revealing the characteristic organoid pattern as well as immunohistochemical positivity for characteristic markers of MSCNC, including chromogranin A, synaptophysin, and neuron-specific enolase, among others [2]. Historically, these tumors are difficult to treat and interventions that initially appear to be effective frequently result in tumor recurrence and metastases.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Primary Mediastinal Small Cell Neuroendocrine Carcinoma Presenting with Superior Vena Cava Syndrome

Costanzo

Kewan

Kerwin

et al. 2019

Cureus

View full text Add to dashboard Cite

A mediastinal small cell neuroendocrine carcinoma (MSCNC) is a rare form of neuroendocrine malignancy. Diagnosis is challenging and requires pathological identification and imaging studies. These tumors are aggressive and recurrence and metastases frequently complicate patient management. Here, we present a case of superior vena cava (SVC) syndrome secondary to circumferential compression by a primary MSCNC.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Primary Mediastinal Small Cell Neuroendocrine Carcinoma Presenting with Superior Vena Cava Syndrome

Costanzo

Kewan

Kerwin

et al. 2019

Cureus

View full text Add to dashboard Cite

show abstract

A Rare Case of Giant Neuroendocrine Tumor of the Thymus Treated with EN Bloc Resection

Fracasso

Albuquerque

Rovani

et al. 2019

ijirms

View full text Add to dashboard Cite

Neuroendocrine tumors (NETs) are epithelial neoplasms with predominant neuroendocrine differentiation that arise in most organs of the body. Neuroendocrine tumors of the thymus (tNET) and mediastinum are very uncommon. We report the case of a 49-year-old male patient with neuroendocrine tumor of the thymus, superiorly in the anterior mediastinum, asymptomatic of the respiratory tract presenting with epigastric pain, treated with the lesion's surgical resection en bloc associated with radiotherapy and chemotherapy.

show abstract

Idiopathic Pulmonary Fibrosis Comorbid With Mediastinal Small Cell Carcinoma: A Clinical Dilemma

Shakir,

Abdul Basit,

Ray

et al. 2024

Cureus

View full text Add to dashboard Cite

We present an interesting case of mediastinal small cell carcinoma (MSCC), an exceedingly rare entity, comorbid with idiopathic pulmonary fibrosis (IPF). A 66-year-old female was first seen in the pulmonology office for abnormal chest computed tomography (CT) findings of right apical bronchiectasis and subpleural fibrotic changes with focal pleural thickening along the fissures, along with a right lower lobe nodule. Pulmonary function testing (PFT) showed an obstructive pattern with modest bronchodilator response, although subsequent PFT showed a worsening restrictive pattern with a worsening DLCO. On a follow-up CT one year later, a soft tissue density with peripheral calcification was found in the anterior mediastinum, later found to be hypermetabolic on a PET scan. Radiographically, fibrosis worsened with the appearance of worsening diffuse bilateral coarse reticular interstitial changes with lower lobe predominance, honeycombing, and areas of ground-glass opacity. A biopsy of the mediastinal lesion showed a high-grade neuroendocrine tumor. Cam5.2, insulinoma-associated protein-1, synaptophysin, and thyroid transcription factor-1 immunostains were positive. She underwent four cycles of chemotherapy with cisplatin and etoposide with a total of 60 Gy of radiation. Mediastinal mass started to decrease in size. Her respiratory status, imaging, and PFTs continued to show evidence of IPF progression. Prednisone resulted in modest clinical and radiographic response. Steroid-sparing therapy with mycophenolate mofetil, although effective, had to be discontinued due to GI bleeding. Anti-fibrotic therapy was deferred due to evidence showing a lack of clinical improvement. We discuss the existing evidence available on IPF management and proceed to highlight the deficiencies in existing data available on the management of IPF and MSCC in these patients. Most of the cases of MSCC reported in the past have managed MSCC using guidance from treatment practices for small cell lung cancer. No reported cases discuss or describe the management of IPF and MSCC in the very rare cohort of patients our case represents.

show abstract

Mediastinum primary small cell neuroendocrine carcinoma

Cited by 3 publications

References 8 publications

Primary Mediastinal Small Cell Neuroendocrine Carcinoma Presenting with Superior Vena Cava Syndrome

Primary Mediastinal Small Cell Neuroendocrine Carcinoma Presenting with Superior Vena Cava Syndrome

A Rare Case of Giant Neuroendocrine Tumor of the Thymus Treated with EN Bloc Resection

Idiopathic Pulmonary Fibrosis Comorbid With Mediastinal Small Cell Carcinoma: A Clinical Dilemma

Contact Info

Product

Resources

About