Objective. This study explored the characteristics and associated factors of commercial sex behavior among male college students who engaged in temporary heterosexual behaviors in Zhejiang Province, China. Methods. The participants were male college students with temporary heterosexual behaviors. We developed an online questionnaire to collect information on demographic characteristics, sexual attitudes, sexual behaviors, and HIV/AIDS interventions through stratified cluster sampling. Chi-square (
χ
2
) tests were performed for the different groups of participants. The occurrence of commercial sex behavior among participants was taken as the dependent variable, and logistic regression was used to analyze the factors associated with the participants’ commercial sex behavior. Results. This study investigated the temporary heterosexual behavior of 424 male college students. Among them were 112 students who reported commercial sex behavior (26.42%), whose average age was
20.25
±
1.27
years, and whose household registration of Zhejiang Province accounted for 63.39%. The results of the multivariate logistic regression analysis indicated that acceptance of commercial sex behavior (Adjusted (a)
OR
=
3.53
, 95%
CI
=
1.94
~6.40) and feeling at risk of contracting HIV (
aOR
=
6.44
, 95%
CI
=
2.98
~13.94), seeking temporary sexual partners through the Internet (
aOR
=
2.58
, 95%
CI
=
1.27
~5.25), consistently using condoms during sex (
aOR
=
0.34
, 95%
CI
=
0.16
~0.70), or using condoms sometimes/frequently during sex (
aOR
=
0.30
, 95%
CI
=
0.13
~0.68) were independent factors associated with male college students with temporary heterosexual behavior engaging in commercial sex behavior. Conclusion. Open sexual attitudes, seeking temporary sexual partners through the Internet, high awareness of HIV infection risk, and low condom use are associated factors for male college students engaging in commercial sex behavior. For college students’ HIV/AIDS prevention and education interventions, it is necessary to strengthen the prevention of network influence, increase peer education, increase teacher participation in education, enhance college students’ risk awareness, advocate for the use of condoms, and promote HIV/AIDS prevention and treatment.