Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults.

Abstract

Background and Aims: The triglyceride glucose (TyG) index was regarded as a simple surrogate marker of insulin resistance (IR). It is confirmed that IR was significantly associated with hyperuricemia, and obesity was the risk factor for IR and hyperuricemia. However, the relationship between the TyG index and hyperuricemia and the potential role of obesity in Han Chinese hypertension are not entirely elucidated.Methods and Results： A community-based cross-sectional study was conducted in 4551 hypertension patients aged 40-75 years with clinical and biochemical data. The TyG index was calculated as ln [fasting triglyceride (mg/dl) × fasting blood glucose (mg/dl)/2]. Hyperuricemia was determined as serum uric acid ≥357μmol/L (6 mg/dl) for females and ≥417μmol/L (7 mg/dl) for males. The TyG index was higher in patients with hyperuricemia than in those without (8.99±0.61, 8.70±0.59, P<0.001). The prevalence of hyperuricemia in patients with the lowest (≤8.32), second (8.33-8.66), third (8.67-9.07) and the highest quartile (≥9.08) of the TyG index was 6.0%, 10.4%, 15.4%, 21.4%, respectively. Logistic regression analysis suggested that the higher quartile of TyG index was associated with increased hyperuricemia risk whether in crude or adjusted models (P<0.05). Mediation analysis showed that all of our obesity indexes partially mediated the association between the TyG index and hyperuricemia to some extent.Conclusion：TyG index is significantly associated with hyperuricemia in hypertension patients among Han Chinese, obesity plays a partial mediation role in this relationship.

Long-term Burden of Higher Body Mass Index from Childhood and Adult Hypertension Are Linked Through Triglyceride-Glucose Index: A 30-year prospective cohort study

“…As a result, it is even more important to examine the impact of long-term BMI measures, including the long-term burden and longitudinal trends of BMI, on long-term hypertension and cardiovascular damage. Some studies have shown that increased childhood BMI and its cumulative burden has long-term adverse impact on subclinical changes in adult cardiac structure and arterial stiffness 22,29 . Similar to these studies, we found that the long-term burden and trends of BMI from childhood to adulthood can increase the risk of hypertension in adults after adjusting for demographic variables.…”