2021
DOI: 10.1253/circrep.cr-21-0013
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Mediation of Arterial Stiffness for Hyperuricemia-Related Decline of Cardiac Systolic Function in Healthy Men

Abstract: Background: This prospective observational study examined whether hyperuricemia may be associated with impaired left ventricular (LV) systolic function and increased cardiac load resulting from increased arterial stiffness. Methods and Results: In 1,880 middle-aged (mean [±SD] age 45±9 years) healthy men, serum uric acid (UA) levels, pre-ejection period/ejection time (PEP/ET) ratio, serum N-terminal pro B-type natriuretic peptide (NT-proBNP) levels, and brachial-ankle p… Show more

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Cited by 3 publications
(3 citation statements)
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“…In this study, the mean PEP/ET in the study participants increased from 0.35±0.05 to 0.36±0.05 during the study period. In our previous study conducted in the same cohort 23) , the PEP/ET was higher in subjects with elevated (≥ 125 pg/mL) serum NT-pro-BNP levels (0.38±0.07, n = 38) than in the subjects without elevated serum NT-pro-BNP levels (0.36±0.05, n = 2628) (p = 0.01) 24) . Therefore, it appears that PEP/ET does reflect the cardiac systolic performance, and our results suggest that an annual decline of the cardiac systolic performance may be observed even in apparently healthy middle-aged Japanese men.…”
Section: # Annual Decline Of the Cardiac Systolic Performancementioning
confidence: 71%
“…In this study, the mean PEP/ET in the study participants increased from 0.35±0.05 to 0.36±0.05 during the study period. In our previous study conducted in the same cohort 23) , the PEP/ET was higher in subjects with elevated (≥ 125 pg/mL) serum NT-pro-BNP levels (0.38±0.07, n = 38) than in the subjects without elevated serum NT-pro-BNP levels (0.36±0.05, n = 2628) (p = 0.01) 24) . Therefore, it appears that PEP/ET does reflect the cardiac systolic performance, and our results suggest that an annual decline of the cardiac systolic performance may be observed even in apparently healthy middle-aged Japanese men.…”
Section: # Annual Decline Of the Cardiac Systolic Performancementioning
confidence: 71%
“…They can work on energy fuel (mixtures of MSW dehydrated to 20% relative humidity and hard coal with a mass fraction of 16%) with an estimated lower calorific value of 10.99 MJ/kg [660]. At the same time, thermal methods of MSW disposal have currently received an ambiguous assessment in world practice, since the technological process of any waste incineration plant is definitely accompanied by complex environmental pollution [18][19][20][21], in particular atmospheric pollution. Flue gases of waste incineration plants are a complex multicomponent mixture, in which 27 components have been identified and quantified…”
Section: The Productivity Influence Of the Waste Incinerator Plant On...mentioning
confidence: 99%
“…Introduction. Hyperuricemia (HU) is a common pathological metabolic disorder among patients with chronic heart failure (CHF) and a significant independent predictor of mortality and re-hospitalization due to worsening of the disease course [19,20,21,22]. Research by Q.…”
mentioning
confidence: 99%