Mediation of pathogen resistance by exudation of antimicrobials from roots

Bais, Harsh P.; Prithiviraj, Balakrishnan; Jha, Ajay Kumar; Ausubel, Frederick M.; Vivanco, Jorge M.

doi:10.1038/nature03356

Cited by 151 publications

(117 citation statements)

References 29 publications

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“…These microarrays contained all ORFs of the two Ti plasmids as well as Ϸ20 chromosomal genes thought to be constitutively expressed and several members of the putative SOS and heat-shock regulons. It seemed conceivable that either or both of these regulons might be AS-inducible, because phenolics are somewhat toxic at the concentrations used (13), and the T-DNA is processed to a single-stranded form (14) that might possibly cause SOS induction (15). As described below, these transcriptional profiling experiments confirmed the induction of virtually all known members of the vir regulons on the Ti plasmids and identified a small number of previously undescribed members.…”

supporting

confidence: 60%

VirA and VirG activate the Ti plasmid repABC operon, elevating plasmid copy number in response to wound-released chemical signals

Cho

Winans

2005

Proc. Natl. Acad. Sci. U.S.A.

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supporting

confidence: 60%

VirA and VirG activate the Ti plasmid repABC operon, elevating plasmid copy number in response to wound-released chemical signals

Cho

Winans

2005

Proc. Natl. Acad. Sci. U.S.A.

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“…In our experiments, genes encoding translocation proteins involved in type III secretion (pscR, pscQ, and pscP) showed a complex pattern of regulation in response to the root exudates. Such complexities in regulation of bacterial gene expression in response to plant root exudates might be expected because exudates comprise a complex mixture of molecular signals and metabolites (15,21,30) and potential inhibitory compounds (31,32).…”

Section: Resultsmentioning

confidence: 99%

Transcriptome profiling of bacterial responses to root exudates identifies genes involved in microbe-plant interactions

Mark

Dow

Kiely

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

226

166

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Molecules exuded by plant roots are thought to act as signals to influence the ability of microbial strains to colonize the roots and to survive in the rhizosphere. Differential bacterial responses to signals from different plant species may mediate the selection of specific rhizosphere populations. Very little, however, is known about the effects of plant exudates on patterns of bacterial gene expression. Here, we have tested the concept that plant root exudates modulate expression of bacterial genes involved in establishing microbe-plant interactions. We have examined the influence on the Pseudomonas aeruginosa PA01 transcriptome of exudates from two varieties of sugarbeet that select for genetically distinct pseudomonad populations in the rhizosphere. The response to the two exudates showed only a partial overlap; the majority of those genes with altered expression was regulated in response to only one of the two exudates. Genes with altered expression included those with functions previously implicated in microbe-plant interactions, such as aspects of metabolism, chemotaxis and type III secretion, and a subset with putative or unknown function. Use of a panel of mutants with targeted disruptions allowed us to identify previously uncharacterized genes with roles in the competitive ability of P. aeruginosa in the rhizosphere within this subset. No genes with host-specific effects were identified. Homologues of the genes identified occur in the genomes of both beneficial and pathogenic root-associated bacteria, suggesting that this strategy may help to elucidate molecular interactions that are important for biocontrol, plant growth promotion, and plant pathogenesis.Pseudomonas ͉ Rhizosphere colonization

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“…And developments of new antimicrobial agents whenever resistant bacteria appear have been repeated [11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and antifungal activities of isoprenoids

Nagaki

Narita

Ichikawa

et al. 2011

Trans. Mat. Res. Soc. Japan

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We assayed biologically significant isoprenoids for antibacterial and antifungal activities. Isoprenoids varied widely with respect to their growth inhibitory activities towards Gram-positive and Gram-negative bacteria and fungal species. Of particular interest was the finding that geraniol acted as a broad spectrum of antibiotic, and significantly inhibited the growth of Gram-positive Staphylococcus aureus 209P and methicillin resistant S. aureus 834, Gram-negative Escherichia coli IFO-3806, and Shigella sonnei, as well as the fungus Trichopyton sp. Farnesol inhibited S. aureus strains 209P and 834 to a greater extent than did geraniol, but did not detectably inhibit Gram-negative bacteria.

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Mediation of pathogen resistance by exudation of antimicrobials from roots

Cited by 151 publications

References 29 publications

VirA and VirG activate the Ti plasmid repABC operon, elevating plasmid copy number in response to wound-released chemical signals

VirA and VirG activate the Ti plasmid repABC operon, elevating plasmid copy number in response to wound-released chemical signals

Transcriptome profiling of bacterial responses to root exudates identifies genes involved in microbe-plant interactions

Antibacterial and antifungal activities of isoprenoids

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