Mediators Produced by Airway Epithelial Cells Influence Proliferation and Differentiation of Immature Mast Cells

Pompen, M.; Jansen, Henk M.; Out, Theo A.; Lutter, René

doi:10.1159/000237603

Cited by 1 publication

(2 citation statements)

References 6 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have studied the effects of human mast cells on T cells with the use of the human mast cell line HMC‐1. This is an immature mast cell line with tryptase levels being 1/10th of normal human lung mast cells 19,29 . Although the cell‐line cells have been shown to share many characteristics with native mast cells 18 they lack the γ‐chain of the FcεI receptor and have a mutation in the c‐kit receptor.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Products from human mast cell line cells enhance the production of interferon‐γ by CD8⁺ and CD4⁺ T cells

et al. 2002

Self Cite

View full text Add to dashboard Cite

SUMMARYIn patients with allergic asthma, T-cell cytokines are implicated in the regulation of the local inflammation in the airways. The ability of sensitized mast cells to release mediators and cytokines early upon allergen stimulation makes them important candidates for local immunoregulation. We have studied the effects of human mast cells on T cells with the use of the human mast cell line HMC-1. We showed that activated human mast cells or their soluble products induced and enhanced the interferon-c (IFN-c) production by T cells up to about 60-fold. The production of interleukin (IL)-4 was hardly affected and that of IL-5 was slightly enhanced. The enhancement of IFN-c production was induced both in polyclonal CD4 + and CD8 + T cells and in CD4 + and CD8 + T-cell clones. Further characterization of the factors involved demonstrated a molecular mass above 30 000. Our results implicate that by this mechanism mast cells may account for a negative feedback system locally down-regulating allergen-induced T helper 2 responses via IFN-c production by the T cells.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Human mast cell‐line cells (HMC‐1) were from Dr J. Butterfield 17 . Cells were kept in culture medium I as described 19 . Before using mast cells in the assays they were prepared as follows.…”

Section: Methodsmentioning

confidence: 99%

Products from human mast cell line cells enhance the production of interferon‐γ by CD8⁺ and CD4⁺ T cells

et al. 2002

Self Cite

View full text Add to dashboard Cite

show abstract

Mediators Produced by Airway Epithelial Cells Influence Proliferation and Differentiation of Immature Mast Cells

Cited by 1 publication

References 6 publications

Products from human mast cell line cells enhance the production of interferon‐γ by CD8⁺ and CD4⁺ T cells

Products from human mast cell line cells enhance the production of interferon‐γ by CD8⁺ and CD4⁺ T cells

Contact Info

Product

Resources

About

Mediators Produced by Airway Epithelial Cells Influence Proliferation and Differentiation of Immature Mast Cells

Cited by 1 publication

References 6 publications

Products from human mast cell line cells enhance the production of interferon‐γ by CD8+ and CD4+ T cells

Products from human mast cell line cells enhance the production of interferon‐γ by CD8+ and CD4+ T cells

Contact Info

Product

Resources

About

Products from human mast cell line cells enhance the production of interferon‐γ by CD8⁺ and CD4⁺ T cells

Products from human mast cell line cells enhance the production of interferon‐γ by CD8⁺ and CD4⁺ T cells