2015
DOI: 10.1155/2015/975632
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Mediators, Receptors, and Signalling Pathways in the Anti-Inflammatory and Antihyperalgesic Effects of Acupuncture

Abstract: Acupuncture has been used for millennia to treat allergic diseases including both intermittent rhinitis and persistent rhinitis. Besides the research on the efficacy and safety of acupuncture treatment for allergic rhinitis, research has also investigated how acupuncture might modulate immune function to exert anti-inflammatory effects. A proposed model has previously hypothesized that acupuncture might downregulate proinflammatory neuropeptides, proinflammatory cytokines, and neurotrophins, modulating transie… Show more

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Cited by 46 publications
(36 citation statements)
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“…Previous studies indicated acupuncture could exert its therapeutic effect via an anti-inflammatory effect. 7 Acupuncture could alleviate migraine by decreasing matrix metalloproteinase-2 activity and modulating inflammatory mediators by affecting the CB1 receptor. 8 Our previous study found that EA at the GB20 acupoint decreases calcitonin gene-related peptide (CGRP) expression in the trigeminal ganglion (TG) and alleviates electronic stimulation-induced hyperalgesia.…”
Section: Introductionmentioning
confidence: 99%
“…Previous studies indicated acupuncture could exert its therapeutic effect via an anti-inflammatory effect. 7 Acupuncture could alleviate migraine by decreasing matrix metalloproteinase-2 activity and modulating inflammatory mediators by affecting the CB1 receptor. 8 Our previous study found that EA at the GB20 acupoint decreases calcitonin gene-related peptide (CGRP) expression in the trigeminal ganglion (TG) and alleviates electronic stimulation-induced hyperalgesia.…”
Section: Introductionmentioning
confidence: 99%
“…Acupuncture has been suggested to ameliorate inflammation and nociception by influencing inflammatory cytokines/chemokines 38 . Consistent with previous studies, we observed increased levels of white blood cells (WBCs) and reticulocytes, and decreased hematocrit in whole blood of sickle mice as compared to control mice ( Supplementary Table 1 ).…”
Section: Resultsmentioning
confidence: 99%
“…A review by Takahashi 31 has suggested that acupuncture may regulate the imbalance between the parasympathetic and sympathetic activity. More recently, studies have examined the mechanisms underlying the anti-inflammatory effects of acupuncture in allergic rhinitis, which facilitated modulation of the nervous, endocrine and immune systems 32 33 . Overall, these studies indicated that the anti-inflammatory mechanisms of acupuncture appear to be mediated by down-regulation of pro-inflammatory neuropeptide, neurotrophins, Th2 cytokines and pro-inflammatory cytokines, thus enhancing the Th1/Th2 balance towards Th1 direction.…”
Section: Discussionmentioning
confidence: 99%