Medibots: Dual‐Action Biogenic Microdaggers for Single‐Cell Surgery and Drug Release

Srivastava, Sarvesh Kumar; Medina‐Sánchez, Mariana; Koch, Britta; Schmidt, Oliver G.

doi:10.1002/adma.201504327

Cited by 230 publications

(216 citation statements)

References 70 publications

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“…A rotating magnetic field can also be employed to actuate "microdaggers" to drill holes on cells. Srivastava et al coated calcified porous microneedles from plant with Fe-Ti to facilitate their actuation, so that these microdaggers can be manipulated to drill holes on cells and perform site-specific drug delivery [82].…”

Section: Other Designsmentioning

confidence: 99%

Recent developments in magnetically driven micro- and nanorobots

Chen

Hoop

Mushtaq

et al. 2017

Applied Materials Today

335

211

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Micro-and nanorobots are promising devices for biomedical and environmental applications. The past few years have witnessed rapid developments in this field. This short review intends to address recent progress on magnetically driven micro-and nanorobots developed in our laboratory and by other research groups. Different designs such as helical swimmers, flexible swimmers, surface walkers, and others are categorized and discussed. Specific applications of these robots in the fields of biomedicine or environmental remediation are also reported. Finally, the use of magnetic fields for additional capabilities beyond manipulation is presented.

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Section: Other Designsmentioning

confidence: 99%

Recent developments in magnetically driven micro- and nanorobots

Chen

Hoop

Mushtaq

et al. 2017

Applied Materials Today

335

211

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“…Apart from cells with complete membrane systems, researchers are exploiting many more natural derivatives. For example, Srivastava et al extracted raphides from plants as anticancer drug carriers (Table 2) [80]. After coating with a magnetic layer, drug-loaded raphides played a dual-action role as drug carriers and as microdaggers to kill cancer cells deterministically in a magnetic field ( Figure 3C).…”

Section: Cells/microorganisms As Drug Carriersmentioning

confidence: 99%

Micro- and nano-motors: the New Generation of Drug Carriers

2018

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Micro-and nano-motors are emerging as novel drug delivery platforms, offering advantages such as rapid drug transport, high tissue penetration and motion controllability. They can be propelled and/or guided by endogenous (i.e., chemotaxis) or exogenous stimuli (e.g., ultrasound, magnetic fields, light) toward the area of interest. Moreover, such stimuli can be used to trigger the release of a therapeutic payload when the motor reaches certain location in order to improve the drug targeting. In this review article, we highlight medically oriented micro-/nano-motors, in particular the ones created for targeted drug delivery, and discuss their current limitations and possibilities toward in vivo applications. Drug-delivery systems have greatly evolved since 1952, when the first sustained release systems were introduced (see the graphical abstract) [1]. In the 1980s, self-regulated drug release carriers as well as the first drug delivery nanostructures were developed. From then on, research in this field has been focused on improving the targeting and systemic circulation of those carriers as well as to study different nanoparticle-based drug formulations, topics which have been widely reviewed in the literature [2][3][4][5][6][7]. Several nanocarriers (between 5 and 200 nm diameter) have been explored for therapy (e.g. inorganic, polymeric, liposomes, nanocrystals, nanotubes and dendrimers) [8], many of them already approved by the Food and Drug Administration (FDA) to treat, for example, neurovascular diseases, neurological cancers and neurodegenerative maladies [9]. The study of their pharmacokinetics has led to the creation of new carriers with reduced drug dose and protection from efflux or degradation [10]. Most of these nanocarriers include sophisticated surface biofunctionalization and coatings like polyethylene glycol (PEG) [11] or biomimetic modifications, [12] to increase their specificity and circulation time [13]. However, challenges still remain for those carriers such as the improvement of their targeting (currently only about 0.7% -median -of the administrated nanoparticle dose is found to be delivered to a solid tumor [14]), their penetration ability, drug loading capacity and delivery on the subcellular level. Other type of drug carriers are the cellular ones, which have many advantages such Graphical abstract:

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“…Therefore, motors can be a very attractive platform for solving complicated in vivo problems because macroscopic medical devices that are currently used in therapeutic processes can result in patient discomfort, postoperative complications, and tissue damage . Srivastava et al reported calcified porous microneedles that can function as cell penetrating and drug transporting tools . Extracted from Dracaena sp.…”

Section: Introductionmentioning

confidence: 99%

Wireless Manipulation of Magnetic/Piezoelectric Micromotors for Precise Neural Stem‐Like Cell Stimulation

Liu

Chen

Liu

et al. 2020

Adv Funct Materials

106

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Precise neural electrical stimulation, which is a means of promoting neuronal regeneration, is a promising solution for patients with neurotrauma and neurodegenerative diseases. In this study, wirelessly controllable targeted motion and precise stimulation at the single‐cell level using S.platensis@Fe3O4@tBaTiO3 micromotors are successfully demonstrated for the first time. A highly versatile and multifunctional biohybrid soft micromotor is fabricated via the integration of S.platensis with magnetic Fe3O4 nanoparticles and piezoelectric BaTiO3 nanoparticles. The results show that this micromotor system can achieve navigation in a highly controllable manner under a low‐strength rotating magnetic field. The as‐developed system can achieve single‐cell targeted motion and then precisely induce the differentiation of the targeted neural stem‐like cell by converting ultrasonic energy to an electrical signal in situ owing to the piezoelectric effect. This new approach toward the high‐precision stimulation of neural stem‐like cells opens up new applications for micromotors and has excellent potential for precise neuronal regenerative therapies.

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Medibots: Dual‐Action Biogenic Microdaggers for Single‐Cell Surgery and Drug Release

Cited by 230 publications

References 70 publications

Recent developments in magnetically driven micro- and nanorobots

Recent developments in magnetically driven micro- and nanorobots

Micro- and nano-motors: the New Generation of Drug Carriers

Wireless Manipulation of Magnetic/Piezoelectric Micromotors for Precise Neural Stem‐Like Cell Stimulation

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