Medicación antihipertensiva y sus reacciones adversas en la cavidad oral. Una revisión integrativa

Armijos, Diego Armando Lalvay; Espin, Andy Oswaldo Castañeda; Carrera, Diego Fernando Cobos

doi:10.33448/rsd-v11i10.32624

Cited by 3 publications

(5 citation statements)

References 20 publications

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“…As explained before, there is no significant correlation between hypertension and oral lesions, the coexistence of both conditions is possibly because of medication used in hypertension that causes hyposalivation. 15 19 20 In this study, 125 elderly (85.03%) use amlodipine as their medication. amlodipine is a first-choice antihypertensive drug from the group of calcium channel blockers that has a mechanism of action by inhibiting the influx of calcium ions into heart muscle cells and vascular smooth muscle so that the relaxing effect results in decreasing BP.…”

Section: Discussionmentioning

confidence: 87%

“…14 Current studies state that there is no recognized oral manifestation of hypertension but medication using antihypertensive drugs can often develop side effects in the oral cavity. 15 This study focuses on normal variant lesions on the tongue because the previous study showed that the tongue is a good indicator of the oral cavity as a mirror of general health and easy accessibility in daily examination. 16 The result of this study showed that fissured tongue is the most common normal variant lesions on the tongue found in the elderly with hypertension (n ¼ 133; 90.48%).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Tongue Normal Variant Lesions in Geriatric Patients with Hypertension in Surabaya: A Multicenter Observational Study

Parmadiati,

Mahdani,

Ernawati

et al. 2023

Journal of Health and Allied Sciences NU

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Introduction The risk of degenerative diseases in the elderly is higher due to aging and decreased body function. This process affects both systemic conditions and locally in the oral cavity. Aside from aging, degenerative disease itself can trigger the incidence of soft tissue abnormalities. Aging can cause structural and functional changes in the systemic vasculature, resulting in a degenerative disease such as hypertension. Elderly who suffers from hypertension can develop oral mucosa abnormalities and most of them are found on the tongue. This study was aimed to identify the prevalence of normal variant lesions on the tongue in the elderly with hypertension. Methods This was an observational descriptive study with a cross-sectional design done in January–March 2020. Samples were elderly obtained from several public health centers in Surabaya that matched the inclusion criteria. Subjective and clinical examinations were performed by oral medicine residents and specialists. Results A total of 401 elderly were screened and 147 elderly (36.65%) met the inclusion criteria which are having hypertension and willing to participate in this study. Those who met the criteria, mainly were female from the 60 to 74 years old age group. Normal variants of tongue obtained from the examination were fissured tongue (90.48%), coated tongue (63.95%), crenated tongue (33.33%), lingual varices (12.24%), and benign migratory glossitis (4.08%). Conclusion From this study, we figured out that fissured tongue was the most common normal variant lesion of the tongue in the elderly with hypertension. Coexistence between hypertension and tongue lesions can be developed from pathological changes of disease or as side effects of medication taken such as antihypertensive drugs.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Prevalence of Tongue Normal Variant Lesions in Geriatric Patients with Hypertension in Surabaya: A Multicenter Observational Study

Parmadiati,

Mahdani,

Ernawati

et al. 2023

Journal of Health and Allied Sciences NU

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“…Ayinampudi et al [22] Hemodialyzed non-diabetic patients (11) Candida observed in 3 samples (27%) The high-risk ratio (1.774) is an indication that the presence of Candida is probably higher in diabetic patients.…”

Section: Reference Group (N) Results Conclusionmentioning

confidence: 99%

“…Medications used in the treatment of hypertension may lead to gingival overgrowth, xerostomia, salivary gland swelling, lichenoid reactions, taste disorders, and parathesis [10]. Most side effects are observed in therapy with the following group of medications: angiotensin-converting enzyme inhibitors, calcium channel blockers, and diuretics [11].…”

Section: Introductionmentioning

confidence: 99%

Oral Findings in Hemodialyzed Patients Diagnosed with Diabetes Mellitus and/or Hypertension—A Systematic Review

Trzcionka,

Mączkowiak,

Korkosz

et al. 2023

JCM

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Chronic kidney disease is classified as a civilization disease and is being diagnosed in an increasing number of patients. Hypertension and diabetes mellitus often coexist in hemodialyzed patients. The aim of the present study was to identify publications on the oral cavity status of multimorbid hemodialyzed adult patients additionally diagnosed with hypertension and/or diabetes mellitus, published between 2012 and 2022 to establish evidence of the impact of hypertension and diabetes mellitus on the oral status of hemodialyzed patients. Scopus and Web of Science databases were searched. Eight articles were included in the review. In total, 3 articles discussed oral hygiene in hemodialyzed patients, 4 discussed periodontal status, 3 discussed mucosa condition and saliva parameters, and 3 discussed the problem of Candidiasis infections. The conclusions were as follows: there is still a limited number of publications discussing the oral status of hemodialyzed patients diagnosed with hypertension; involved articles have proven that coexisting diseases can influence the oral cavity status of hemodialyzed patients and cause periodontal disorders, lower hygiene status, saliva parameters and make the risk of Candida infections higher.

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“…The long-term use of anti-hypertension medications results further in xerostomia [159]. Dry mouth then raises caries prevalence in the mouth of the users.…”

Section: Anti-hypertensivesmentioning

confidence: 99%

An Update on Drug–Nutrient Interactions and Dental Decay in Older Adults

Bell,

Rodrigues,

Antoniadou

et al. 2023

Nutrients

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In recent decades, the global demographic landscape has undergone a discernible shift that has been characterised by a progressive increase in the proportion of elderly individuals, indicative of an enduring global inclination toward extended lifespans. The aging process, accompanied by physiological changes and dietary patterns, contributes to detrimental deviations in micronutrient consumption. This vulnerable aging population faces heightened risks, including dental caries, due to structural and functional modifications resulting from insufficient nutritional sustenance. Factors such as physiological changes, inadequate nutrition, and the prevalence of multiple chronic pathologies leading to polypharmacy contribute to the challenge of maintaining an optimal nutritional status. This scenario increases the likelihood of drug interactions, both between medications and with nutrients and the microbiome, triggering complications such as dental decay and other pathologies. Since the drug industry is evolving and new types of food, supplements, and nutrients are being designed, there is a need for further research on the mechanisms by which drugs interfere with certain nutrients that affect homeostasis, exemplified by the prevalence of caries in the mouths of older adults. Infectious diseases, among them dental caries, exert serious impacts on the health and overall quality of life of the elderly demographic. This comprehensive review endeavours to elucidate the intricate interplay among drugs, nutrients, the microbiome, and the oral cavity environment, with the overarching objective of mitigating the potential hazards posed to both the general health and dental well-being of older adults. By scrutinising and optimising these multifaceted interactions, this examination aims to proactively minimise the susceptibility of the elderly population to a spectrum of health-related issues and the consequences associated with dental decay.

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Medicación antihipertensiva y sus reacciones adversas en la cavidad oral. Una revisión integrativa

Cited by 3 publications

References 20 publications

Prevalence of Tongue Normal Variant Lesions in Geriatric Patients with Hypertension in Surabaya: A Multicenter Observational Study

Prevalence of Tongue Normal Variant Lesions in Geriatric Patients with Hypertension in Surabaya: A Multicenter Observational Study

Oral Findings in Hemodialyzed Patients Diagnosed with Diabetes Mellitus and/or Hypertension—A Systematic Review

An Update on Drug–Nutrient Interactions and Dental Decay in Older Adults

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