Medical and Personal Care Applications of Bacteriocins Produced by Lactic Acid Bacteria

Dicks, Leon M. T.; Heunis, Tiaan; Staden, Anton D. van; Brand, A.M.; Noll, Katia Sutyak; Chikindas, Michael L.

doi:10.1007/978-1-4419-7692-5_19

Cited by 33 publications

(22 citation statements)

References 269 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bacteriocins are effective against four of the aforementioned clinically relevant antibiotic targets. Some bacteriocins have been studied in vivo and were successful in inhibiting the targeted pathogens (for review see [27]). These findings support the necessity for further clinical investigation.…”

Section: Bacteriocins Utilise Some Of the Conventional Drug Targetsmentioning

confidence: 99%

See 1 more Smart Citation

Bacteriocins and their position in the next wave of conventional antibiotics

Cavera

Arthur

Kashtanov

et al. 2015

International Journal of Antimicrobial Agents

161

View full text Add to dashboard Cite

Section: Bacteriocins Utilise Some Of the Conventional Drug Targetsmentioning

confidence: 99%

“…These targets include: (i) bacterial peptidoglycan/cell wall disruption; (ii) protein biosynthesis; (iii) folate biosynthesis; (iv) DNA replication and transcription; and (v) disruption of the bacterial membrane [17,[25][26][27][28][29][30].…”

Section: Bacteriocins Utilise Some Of the Conventional Drug Targetsmentioning

confidence: 99%

Bacteriocins and their position in the next wave of conventional antibiotics

Cavera

Arthur

Kashtanov

et al. 2015

International Journal of Antimicrobial Agents

161

View full text Add to dashboard Cite

“…; Dicks et al . ). Isolation and identification of Lactobacillus pentosus SJ65 using 16S rRNA and multiplex polymerase chain reaction (PCR) from fermented Uttapam batter has already been reported elsewhere (Saraniya and Jeevaratnam ).…”

Section: Introductionmentioning

confidence: 97%

“…Because LAB have the generally recognized as safe status, acting as efficient probiotic to human health, the bacteriocins produced by them are usually nontoxic and safe. Thus, bacteriocins of LAB can be used as biopreservatives in foods or applications preserving human health (Jeevaratnam et al 2005;Dicks et al 2011). Isolation and identification of Lactobacillus pentosus SJ65 using 16S rRNA and multiplex polymerase chain reaction (PCR) from fermented Uttapam batter has already been reported elsewhere (Saraniya and Jeevaratnam 2012).…”

Section: Introductionmentioning

confidence: 98%

Purification and Mode of Action of Antilisterial Bacteriocins Produced byLactobacillus pentosus SJ65 Isolated fromUttapamBatter

Saraniya

Jeevaratnam

2014

Journal of Food Biochemistry

View full text Add to dashboard Cite

Humans and lactic acid bacteria (LAB) have allied relationships for thousands of years, where LAB has been involved in food preservations as well as in preserving human health against several pathogens. This study aims at partial purification of bacteriocins from Lactobacillus pentosus SJ65 isolated from fermented Uttapam batter, a South Indian fermented food source, their characterization and mode of action. The bacteriocin was purified using various strategies such as acetone precipitation, gel permeation and hydrophobic interaction chromatography. The bacteriocin was stable at acidic and neutral pH and up to 100C and exhibited a wide spectrum of activity against clinically relevant gram-positive and gram-negative pathogens. However, Tris-tricine sodium dodecyl sulfate, native polyacrylamide gel electrophoresis and its gel half activity assay against Listeria monocytogenes showed that the purified bacteriocin is composed of two independent peptides with molecular weight of 3.9 and 1.6 kDa. PRACTICAL APPLICATIONSBacteriocins, proteinaceous antimicrobial compounds from lactic acid bacteria, are receiving attention for their contribution in food preservation. In addition, interests are created for their use against human bacterial, fungal infections and cancer treatment. To date, only nisin and pediocin have been approved by the United States Food and Drug Administration for use in food industries as preservatives and marketed worldwide. Other bacteriocins such as lactacins, plantaricins, pentocins, etc., are in their own lines of progress for several applications. Bacteriocins are advantageous being less toxic, having broad spectrum of activity and exhibiting antimicrobial activity at nanomolar concentrations. Thus, bacteriocins can be a potential drug candidate for replacing antibiotics to treat drug-resistant pathogens in the future.

show abstract

“…Bacteriocins are often inseparable from probiotics, being one of the weapons used by these healthy bacteria in their combat against pathogens [22]. The last few years have seen a trend in broadening exploration of possible use of bacteriocins in personal care and medical applications [23]. Bacteriocins from Gram-positive bacteria are increasingly reported as active against Gram-negative microorganisms when used in combination with synergistically acting substances [24], or even alone [25].…”

mentioning

confidence: 99%

Probiotics and Antimicrobial Peptides: The Creatures’ and Substances’ Future in the Twenty-First Century: An Opinion Letter

Chikindas

2014

Probiotics & Antimicro. Prot.

View full text Add to dashboard Cite

Medical and Personal Care Applications of Bacteriocins Produced by Lactic Acid Bacteria

Cited by 33 publications

References 269 publications

Bacteriocins and their position in the next wave of conventional antibiotics

Bacteriocins and their position in the next wave of conventional antibiotics

Purification and Mode of Action of Antilisterial Bacteriocins Produced byLactobacillus pentosus SJ65 Isolated fromUttapamBatter

Probiotics and Antimicrobial Peptides: The Creatures’ and Substances’ Future in the Twenty-First Century: An Opinion Letter

Contact Info

Product

Resources

About