Medical and surgical outcomes in childhood glaucoma: A population-based study

Abstract

Introduction To describe the clinical and surgical outcomes among patients under 20 years of age diagnosed with glaucoma in a defined population over a 40-year period. Methods The medical records of all patients (<20 years) diagnosed with glaucoma in Olmsted County, Minnesota, from January 1, 1965, through December 31, 2004, were retrospectively reviewed. Results Thirty children (45 eyes) were diagnosed with various forms of glaucoma during the 40-year study period. During a mean follow-up of 12.5 years (range, 7 days to 32 years), 18 (60%) of the 30 children underwent a mean of 2.7 surgeries (range, 1 to 10), including 6 (20%) patients whose sole surgery consisted of enucleation or evisceration for a blind, painful eye. Twenty-eight (93%) of the 30 children required medical management during the follow-up period, including 14 (47%) treated before their first surgery. At the final follow-up examination, 11 (37%) had a visual acuity of 20/200 or worse. The 10-year Kaplan-Meier risk of vision declining below 20/200 in all glaucoma patients was 22.7% (95% CI, 0-40.9), and patients requiring any glaucoma surgery was 68.3% (95% CI, 42.4-82.6). Conclusions In this population-based study of children diagnosed with glaucoma over a 40-year period, the majority of patients required surgery, with few being successfully controlled by medications alone. A poor visual outcome or the loss of an eye was relatively common.

Incidence, Comorbidity, and Mortality of Primary Congenital Glaucoma in Korea from 2001 to 2015: A Nationwide Population-based Study

“…As expected, visual impairment accounts for the largest number of disabilities in patients with primary congenital glaucoma [ 12 13 ]. Many studies have reported visual prognosis, with 10% losing sight and about 50% having low vision [ 14 15 16 17 18 19 ].…”

Surgical Outcomes in Children with Primary Congenital Glaucoma: A 20-Year Experience

“…It remains an important cause of childhood blindness (3, 7, 8). Primary congenital glaucoma is a recognizable clinical problem in Saudi Arabia, absorbing a significant amount of clinical resources (9) with significant morbidity, leading to lifelong visual disability (10, 11). Some studies revealed that PCG appears in a more severe form in Saudi Arabia than in Western countries (12).…”

The Role of Genetic Ancestry in Brazilian Patients With Primary Congenital Glaucoma

“…7,15,16 The present study was performed to evaluate genetic ancestry and its correlation with clinical data to assess variations in risk factors and disease prognosis.…”