Medical and surgical therapies for keloids

Kelly, A. Paul

doi:10.1111/j.1396-0296.2004.04022.x

Cited by 178 publications

(165 citation statements)

References 23 publications

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“…Currently, pressure garments are predominantly used for the prophylaxis of hypertrophic burn scar formation, despite controversial data regarding their value in reducing excessive scarring and little scientific evidence supporting their use (5). The mechanism of action of pressure therapy remains poorly understood; however, possible mechanisms are decreased collagen synthesis attributable to limiting of the supply of blood, oxygen and nutrients to the scar tissue (86)(87)(88) and increased apoptosis (89).…”

Section: Prophylaxismentioning

confidence: 99%

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz

Körting

Pavicic

et al. 2010

Mol Med

1,176

1,012

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Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient's quality of life, both physically and psychologically. Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. However, most therapeutic approaches remain clinically unsatisfactory, most likely owing to poor understanding of the complex mechanisms underlying the processes of scarring and wound contraction. In this review we summarize the current understanding of the pathophysiology underlying keloid and hypertrophic scar formation and discuss established treatments and novel therapeutic strategies.

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Section: Prophylaxismentioning

confidence: 99%

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Gauglitz

Körting

Pavicic

et al. 2010

Mol Med

1,176

1,012

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“…Female predominance has been noted, but this may, in part, be reflected by the number of earlobe keloids secondary to piercing among women [2,9]. Keloids occur most commonly on the chest, shoulders, upper back, back of the neck, and earlobes.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Clinical Study on Role of 5-Flurouracil Versus Triamcinolone in the Treatment of Keloids

Saha

Mukhopadhyay

2012

Indian J Surg

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A wide range of therapies exist for keloids. But despite the multiple treatment modalities available, keloids still remain a significant challenge for both the clinician and the patient. To compare the efficacy of 5-flurouracil (5-FU) versus triamcinolone as a therapeutic agent for the treatment of keloids. A randomized control trial was carried out at a teaching hospital in Kolkata over a period 2.5 years. Fortyfour patients took part in the study, 20 in group F and 24 in group T. The age ranged from 16 to 66 years. The mean age of group F was 34.7±11.0124 years (range 16-66 years) and of group T was 32.96±9.584 years (range 19-60 years). The difference in the age and sex between the two groups was comparable and not statistically significant (p00.096). The response was rated as excellent (76-100% decrease in volume), good (51-75%), fair (26-50%), and poor (less than 25%). The reduction in keloid volume was comparable in both the groups. But side effects were much more in group F compared to group T. About 95% of the patients in group F found the injection very painful. About 6% of the patients in group F presented soon after the first two to three sessions with superficial ulcerations at the injection site accompanied by mild discomfort and discharge. This side effect was not seen in group T. Regarding pain at the injection site and superficial ulceration, the difference between the two groups was found to be statistically significant (p<0.05). The patients treated with 5-FU experienced side effects such as hyperpigmentation, pain at the injection site, and superficial ulceration, which were statistically highly significant. It appears from this study that triamcinolone is a better tolerated and less toxic alternative to 5-FU in the management of keloids.

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“…Kelly et al studied that higher rate of ear lobe piercing was responsible for slight female predominance over males. 4 The most common site of keloid in the present study was ear lobe which accounted for 52.5%. Ear lobe was found to be the common site due to presence of minor trauma in the form of ear piercing.…”

Section: 3mentioning

confidence: 94%

A Study on Molecular Biology and Pathology of Keloid

Dr.Sudha¹

2018

jmscr

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Medical and surgical therapies for keloids

Cited by 178 publications

References 23 publications

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies

A Comparative Clinical Study on Role of 5-Flurouracil Versus Triamcinolone in the Treatment of Keloids

A Study on Molecular Biology and Pathology of Keloid

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