Medical Applications of Cellulose and its Derivatives: Present and Future

Sindhu, Karthika Ammini; Raghavan, Praveen; Thakur, Vijay Kumar

doi:10.1002/9781118872246.ch16

Cited by 43 publications

(26 citation statements)

References 91 publications

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“…Nanocellulose (NC) is a very attractive material due to its unique properties, i.e., lightweight, strength, flexibility, biodegradability and biocompatibility, wide availability and cost efficiency of the sources [ 1 , 2 , 3 ]. The increasingly severe environmental policies and the exceptional properties of NC promote it as a valuable material for a wide range of applications.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Nanocellulose by Submerged Liquid Plasma for Surface Functionalization

et al. 2018

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Tailoring the surface properties of nanocellulose to improve the compatibility of components in polymer nanocomposites is of great interest. In this work, dispersions of nanocellulose in water and acetonitrile were functionalized by submerged plasmas, with the aim of increasing the quality of this reinforcing agent in biopolymer composite materials. Both the morphology and surface chemistry of nanocellulose were influenced by the application of a plasma torch and filamentary jet plasma in a liquid suspension of nanocellulose. Depending on the type of plasma source and gas mixture the surface chemistry was modified by the incorporation of oxygen and nitrogen containing functional groups. The treatment conditions which lead to nanocellulose based polymer nanocomposites with superior mechanical properties were identified. This work provides a new eco-friendly method for the surface functionalization of nanocellulose directly in water suspension, thus overcoming the disadvantages of chemical treatments.

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Section: Introductionmentioning

confidence: 99%

Treatment of Nanocellulose by Submerged Liquid Plasma for Surface Functionalization

et al. 2018

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“…The clinical application of cellulose-containing 3D scaffolds includes repair, reconstruction, and regeneration of almost all types of tissues in the mammalian organism; this polymer endows scaffolds with the ability to support cell adhesion and growth. In wound dressings, it is no accident that these cellulose-based materials have been used since the mid-1970s, in the form of cotton gauze or non-woven mixtures of rayon and polyester or cotton fibers, since they are capable of absorbing excess exudates through their bulk polar groups (-OH) and allow for the production of highly porous structures, permeable to air, steam, and heat, ensuring the patients comfort [83].…”

Section: Cellulosementioning

confidence: 99%

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

et al. 2020

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Wound healing requires careful, directed, and effective therapies to prevent infections and accelerate tissue regeneration. In light of these demands, active biomolecules with antibacterial properties and/or healing capacities have been functionalized onto nanostructured polymeric dressings and their synergistic effect examined. In this work, various antibiotics, nanoparticles, and natural extract-derived products that were used in association with electrospun nanocomposites containing cellulose, cellulose acetate and different types of nanocellulose (cellulose nanocrystals, cellulose nanofibrils, and bacterial cellulose) have been reviewed. Renewable, natural-origin compounds are gaining more relevance each day as potential alternatives to synthetic materials, since the former undesirable footprints in biomedicine, the environment, and the ecosystems are reaching concerning levels. Therefore, cellulose and its derivatives have been the object of numerous biomedical studies, in which their biocompatibility, biodegradability, and, most importantly, sustainability and abundance, have been determinant. A complete overview of the recently produced cellulose-containing nanofibrous meshes for wound healing applications was provided. Moreover, the current challenges that are faced by cellulose acetate- and nanocellulose-containing wound dressing formulations, processed by electrospinning, were also enumerated.

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“…Cell Culture Scaffolds Cellulose and its derivatives have been used for medical applications-such as in renal dialysis, wound dressings, and anti-bacterial composites-for many years (Sindhu et al 2014). The molecular self-assembly of structural oligosaccharides is one of the targets in the investigation of the effects of carbohydrate clusters on cellular responses, such as in hepatocellular carcinoma cells (Yoshiike and Kitaoka 2011;Kitaoka et al 2013), myoblast cells and their alignment , human embryonic kidney 293 cells (HEK293) expressing toll-like receptor 2 (TLR2) (Hatakeyama et al 2019a), and lectin-binding (Ogawa et al 2012;Hatakeyama et al 2019b) activities.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Inherently Distinctive Potentialities and Uses of Nanocellulose Based on its Nanoarchitecture

Uetani

Ranaivoarimanana

Hatakeyama

et al. 2021

BioRes

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Native cellulose is mainly found in phytomass, such as trees and other plants. It has a regular hierarchical nanoarchitecture, in which the extended macromolecular chains are aligned and closely packed in parallel to form the crystalline nanofibrils of cell walls. In the context of material utilization, nanocellulose is a collective term for nano-ordered assemblies of cellulose chains. In recent times, it has been produced in large quantities from woody bioresources. In addition, nanocellulose has some fascinating physicochemical properties, such as high strength, light weight, transparency, birefringence, and low thermal expansion. These properties have enabled broad functional design of nanocellulose-based materials; but most of them are facing serious competition from various products that already exist. However, nanocellulose is not just a green alternative to existing materials. Rather, it is expected to make a profound difference in terms of pioneering novel functions. The present review focuses on the unexpected features of nanocellulose materials, triggered by details of the inherent nanoarchitecture of native cellulose.

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Medical Applications of Cellulose and its Derivatives: Present and Future

Cited by 43 publications

References 91 publications

Treatment of Nanocellulose by Submerged Liquid Plasma for Surface Functionalization

Treatment of Nanocellulose by Submerged Liquid Plasma for Surface Functionalization

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

Inherently Distinctive Potentialities and Uses of Nanocellulose Based on its Nanoarchitecture

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