Medical Assistant Mobile Application for Diabetes Control by Simulating a Compartmental Model

Abstract

This paper presents an educational mobile assistant application for type 1 diabetes patients. The proposed application is based on four mathematical models that describe the glucose-insulin-glucagon dynamics using a compartmental model, with additional equations to reproduce aerobic exercise, gastric glucose absorption by the gut, and subcutaneous insulin absorption. The medical assistant was implemented in Java and deployed and validated on several smartphones with Android OS. Multiple daily doses can be simulated to perform intensive insulin therapy. As a result, the proposed application shows the influence of exercise periods, food intakes, and insulin treatments on the glucose concentrations. Four parameter variations are studied, and their corresponding glucose concentration plots are obtained, which show agreement with simulators of the state of the art. The developed application is focused on type-1 diabetes, but this can be extended to consider type-2 diabetes by modifying the current mathematical models.

Applications of Medical Informatics and Data Analysis Methods

“…The paper entitled Medical Assistant Mobile Application for Diabetes Control by Simulating a Compartmental Model authored by Hernandez-Ordonez and his coworkers [19] is very interesting and innovative. The authors present an application for mobile phones to assistant patients with type 1 diabetes.…”

An Intelligent Model-Based Effective Approach for Glycemic Control in Type-1 Diabetes

“…Authors suggested a design of mobile application for diabetic patients based on mathematical models illustrating the effects of blood–glucose concentration. The proposed application caters the effects produced during the process of meal intakes and exercise periods on the blood–glucose concentration [ 10 ]. A two-compartmental model is designed using a minimal model for plasma–glucose concentrations for healthy and T1D patients [ 11 ].…”