In the last two decades, evidence has accumulated indicating mostchronic illnesses, including cancer, are caused by a dysregulatedinflammatory response at the molecular level. The discovery oftranscription factors like NF-kB, AP-1, and STAT3, as well as theirgene products like tumour necrosis factor, interleukin-1,interleukin-6, chemokines, cyclooxygenase-2, 5 lipooxygenase,matrix metalloproteases, and vascular endothelial growth factor,adhesion molecules, and others, has provided a molecular basis forthe role of inflammation in cancer. Tobacco, stress, dietary agents,obesity, alcohol, infectious agents, irradiation, and environmentalstimuli all activate these inflammatory pathways, which account forup to 95 percent of all malignancies