Medical Cannabis Use Among Older Adults in Canada: Self-Reported Data on Types and Amount Used, and Perceived Effects

Abstract

Background Medical cannabis use is growing among older adults. In this retrospective study, we aimed to assess the characteristics of older medical cannabis users including the indications, type and amount of cannabis used, perceived changes in symptoms after cannabis use, change in dose of concurrent medications, and adverse effects. Methods Data were collected between October 2014 and October 2020 from patients who were consulting the Canada-wide network of clinics of a medical cannabis provider and who were willing to answer questionnaires based on their medical status. The current study included older adults (≥ 65 years) who completed questionnaires at intake and first follow-up visits. Data were summarized with descriptive statistics, which were compared between men and women with t tests or chi-squared tests. Tests of proportions assessed categorical responses for perceived effects after cannabis use. Logistic regression was used to assess trends in cannabis usage. Results Data included that from 9766 older adult users at intake (mean ± SD age = 73.2 ± 6.8 years, females = 60.0%), among whom 4673 (females = 61.4%) returned for follow-up after 90.6 ± 58 days. The most common primary indication for which medical cannabis was sought was pain (67.7%), which was more common in women, whereas oncological and neurological conditions were more common in men. At follow-up, cannabis oil was used by 81.0% of older adults, among whom compositions containing only or mostly cannabidiol (CBD) had been used by 83.6%. Adverse effects reported by older adults at the follow-up visit included dry mouth (12.8%), drowsiness (8.6%), and dizziness (4.0%). The majority of older adults reported improvements in pain (72.7%, z = 1482.6, p < 0.0001, compared to worsening or no change), sleep (64.5%, z = 549.4, p < 0.0001), and mood (52.8%, z = 16.4, p < 0.0001), with 35.6% reporting use of a reduced dose of opioids and 19.9% a reduced dose of benzodiazepines. Interpretation Among older adults, medical cannabis is used more often by women, with CBD-containing cannabis oils being the most commonly used. Users reported improved pain, sleep, and mood symptoms at follow-up after cannabis use. This study describes the patterns of use of medical cannabis by older adults and highlights the need for research to determine appropriate indications, precise doses of active ingredients, and short- and long-term outcomes among older adults. Supplementary Information The online version contains supplementary material available at 10.1007/s40266-021-00913-y.

Sex-Dependent Prescription Patterns and Clinical Outcomes Associated With the Use of Two Oral Cannabis Formulations in the Multimodal Management of Chronic Pain Patients in Colombia

“…Nevertheless, our results showed that most participants, especially females, initiated their treatment with a CBD-predominant product containing <2 mg/mL of THC. This is in strong agreement with (i) a recent observational study including 9,766 Canadian older adults receiving treatment with medicinal cannabis in which 83.6% were receiving CBMPs containing only or mostly CBD ( 30 ); and (ii) the recommendations by an industry-sponsored multidisciplinary group of global experts who recently developed a set of clinical guidelines for the dosing and administration of cannabinoids to treat chronic pain through a modified Delphi process ( 26 ).…”

Lessons from 20 years of medical cannabis use in Canada

“…It appears that patients who participate in the medical access program increasingly are using cannabis oils instead of dried cannabis. This accords with the results of surveys of individuals who report using cannabis for medical reasons [31][32][33]. Most varieties of cannabis oil sold by Licensed Producers are now high in CBD and low in THC.…”

Impacts of medical and non-medical cannabis on the health of older adults: Findings from a scoping review of the literature

“…More recent US surveys support this finding: more than 75% of adults over 50 who consumed cannabis in the past year had used continuously for at least three years, while less than 6% had initiated use for the first time in the past year [4]. Recent data suggest 6-7% of older adults use cannabis, and amongst them approximately 75% use it for medical purposes [5]. Older adults generally suffer from more chronic health conditions than younger adults (e.g., chronic pain, insomnia) [6,7] and, thus, may be attracted to cannabis for medical purposes [3,8] by marketing efforts that exaggerate the medical and "wellness" benefits of cannabis, while minimizing its harms [9], and by word-of-mouth anecdotal "evidence."…”