Medical Cannabis Use Reduces Opioid Prescriptions in Patients With Osteoarthritis

Renslo, Bryan; Greis, Ari C.; Liu, Conan S; Radakrishnan, Anjithaa; Ilyas, Asif M.

doi:10.7759/cureus.21564

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…11 The clinical relevance of this interaction is difficult to assess because of the high variability in the currently published data. 12,13 More importantly, our data indicate that there may be two subpopulations of marijuana utilizers: marijuana only and those who are multidrug users. Those who only use marijuana seem to have a similar or slightly higher requirement for postoperative opioid pain requirements.…”

Section: Discussionmentioning

confidence: 71%

The Effect of Marijuana on Postoperative Spine Patients' Emergency Department Visits, Readmission Rates, and Opioid Consumption

Buddle,

Lee,

Feng

et al. 2024

JAAOS Glob Res Rev

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Objective: To compare postoperative opioid consumption with patients who tested negative for tetrahydrocannabinol (THC) preoperatively with those who were THC-positive and patients who were positive for THC and any other drug and to compare 90-day rates of postoperative emergency department (ED) visits and 90-day readmission rates, using morphine milligram equivalents (MMEs), for those three patient populations. Methods: Three patient groups were confirmed with preoperative urine drug screens. Chart reviews were conducted to determine whether there was an ED visit or hospital readmission 90 days from the index procedure. MMEs were calculated for all patients. Results: There were a total of 252 patients in the THC-negative control group, 54 in the THC-positive group, and 47 in the THC-and-opioid–positive group. The 90-day ED visit and 90-day readmission rates were not statistically significant among the groups. Both the multidrug and THC-only–positive patients showed a higher 90-day MME compared with the control patients. Discussion: Our study demonstrates that THC used may increase opioid consumption. The THC patients to be cautious toward are the multidrug user. Although not statistically significant, multidrug patients were noted for a trend toward increased ED visits and readmissions.

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Section: Discussionmentioning

confidence: 71%

The Effect of Marijuana on Postoperative Spine Patients' Emergency Department Visits, Readmission Rates, and Opioid Consumption

Buddle,

Lee,

Feng

et al. 2024

JAAOS Glob Res Rev

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“…A compreensão do sistema endocanabinóide está em contínua expansão e estudo, no entanto, na sua essência pode ser definida por três componentes principais: os ligantes (endocanabinóides), os receptores para esses ligantes (receptores canabinóides) e as enzimas responsáveis pela síntese e degradação desses ligantes (20) . Os canabinóides podem ser categorizados em três tipos: fitocanabinóides, endocanabinóides e canabinóides sintéticos.…”

Section: Discussionunclassified

Uso Da Cannabis Medicinal Nos Pacientes Com Dor Crônica

Teixeira Silveira,

Carvalho da Cruz Ramos,

Debbo

et al. 2023

SaudColetiv (Barueri)

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A dor crônica (DC) possui um impacto significativo na qualidade de vida (QV) da população. Ela repercute na capacidade funcional, podendo influenciar em maiores níveis de dependência, distúrbios do sono, alterações do humor e apetite. A descoberta do sistema endocanabinóide na dor demonstrou melhorar a QV de indivíduos com DC. Esse estudo busca analisar o uso da cannabis medicinal (CM) através da experiência terapêutica de pacientes diagnosticados com dor crônica, observando a interferência na dor, sono, humor e na QV e a ocorrência de efeitos colaterais (EC) Trata-se de um estudo observacional longitudinal, descritivo e prospectivo. A coleta foi realizada através de um formulário digital respondido no início do uso do canabinoide, após primeiro mês e no terceiro mês de uso. Os dados revelaram uma associação entre o uso da CM com a melhora da QV e uma deterioração significativa da dor, humor e do sono. Não houve EC significativos.

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“…Another study investigated chronic osteoarthritis (OA) patients, most of whom were using either cannabidiol (CBD) or tetrahydrocannabinol (THC) products in a sublingual tincture form. The findings revealed lower pain scores, improved quality of life, and a decrease in morphine milligram equivalents (MME) among these patients with 37.5% of participants achieving 0 MME/day at the 6-month follow-up (Renslo et al 2022 ). A third cross-sectional study investigated the use CBD on arthritic symptoms among OA, rheumatoid, and other autoimmune arthritis patients.…”

Section: Introductionmentioning

confidence: 99%

Understanding the epidemiology and perceived efficacy of cannabis use in patients with chronic musculoskeletal pain

Leroux,

Ajrawat,

Sundararajan

et al. 2024

J Cannabis Res

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Background The belief that cannabis has analgesic and anti-inflammatory properties continues to attract patients with chronic musculoskeletal (MSK) pain towards its use. However, the role that cannabis will play in the management of chronic MSK pain remains to be determined. This study examined 1) the rate, patterns of use, and self-reported efficacy of cannabis use among patients with chronic MSK pain and 2) the interest and potential barriers to cannabis use among patients with chronic MSK pain not currently using cannabis. Methods Self-reported cannabis use and perceived efficacy were prospectively collected from chronic MSK pain patients presenting to the Orthopaedic Clinic at the University Health Network, Toronto, Canada. The primary dependent variable was current or past use of cannabis to manage chronic MSK pain; bivariate and multivariable logistic regression were used to identify patient characteristics independently associated with this outcome. Secondary outcomes were summarized descriptively, including self-perceived efficacy among cannabis users, and interest as well as barriers to cannabis use among cannabis non-users. Results The sample included 629 patients presenting with chronic MSK pain (mean age: 56±15.7 years; 56% female). Overall, 144 (23%) reported past or present cannabis use to manage their MSK pain, with 63.7% perceiving cannabis as very or somewhat effective and 26.6% considering it as slightly effective. The strongest predictor of cannabis use in this study population was a history of recreational cannabis use (OR 12.7, p<0.001). Among cannabis non-users (N=489), 65% expressed interest in using cannabis to manage their chronic MSK pain, but common barriers to use included lack of knowledge regarding access, use and evidence, and stigma. Conclusions One in five patients presenting to an orthopaedic surgeon with chronic MSK pain are using or have used cannabis with the specific intent to manage their pain, and most report it to be effective. Among non-users, two-thirds reported an interest in using cannabis to manage their MSK pain, but common barriers to use existed. Future double-blind placebo-controlled trials are required to understand if this reported efficacy is accurate, and what role, if any, cannabis may play in the management of chronic MSK pain.

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Medical Cannabis Use Reduces Opioid Prescriptions in Patients With Osteoarthritis

Cited by 5 publications

References 28 publications

The Effect of Marijuana on Postoperative Spine Patients' Emergency Department Visits, Readmission Rates, and Opioid Consumption

The Effect of Marijuana on Postoperative Spine Patients' Emergency Department Visits, Readmission Rates, and Opioid Consumption

Uso Da Cannabis Medicinal Nos Pacientes Com Dor Crônica

Understanding the epidemiology and perceived efficacy of cannabis use in patients with chronic musculoskeletal pain

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