Medical comorbidities predict mortality in women with a history of early stage breast cancer

Abstract

Introduction-This analysis was conducted to determine whether comorbid medical conditions predict additional breast cancer events and all-cause mortality in women with a history of early stage breast cancer.

Obesity, type 2 diabetes, and cancer: the insulin and IGF connection

“…Multiple studies have demonstrated that diabetic patients with breast cancer have lower survival rates than patients without diabetes (Yancik et al 2001, Verlato et al 2003. Patterson et al (2010) reported a more than twofold risk of all-cause mortality in women with breast cancer and T2D compared with nondiabetic breast cancer patients. Erickson et al (2011) analyzed archived baseline blood samples from the Women's Healthy Eating and Living Study for hemoglobin A1C, a measure of chronic glycemia, among women with early-stage breast cancer and found that the risk of allcause mortality increased with increasing hemoglobin A1C.…”

Causes of Morbidity and Mortality from Breast Cancer

“…Diabetes was associated with a high incidence of death (OR = 1.41; 95% CI = 1.28 -1.55) compared to patients with normal blood sugar levels regardless of the type of cancer (OR = 1.61; 95% CI = 1.46 -1.78) [10].…”

“…Finally, diabetes is associated with an adverse prognosis for breast cancer. Considering that 85% of deaths have been caused by breast cancer, these findings suggest that multiple comorbidities may reduce the chance of survival and increase the risk of breast cancer [10].…”

Understanding and influencing the maintenance of physical activity and dietary behaviour change in breast cancer survivors

“…As in the general population, overweight and obese breast cancer survivors are at increased risk of co-morbidities, such as type 2 diabetes and cardiovascular disease (Goodwin et al, 2012;Patterson et al, 2010). International and Australian data indicate that 43% of breast cancer survivors have at least one co-morbid condition (Patterson et al, 2010;Thompson et al, 2008).…”

“…International and Australian data indicate that 43% of breast cancer survivors have at least one co-morbid condition (Patterson et al, 2010;Thompson et al, 2008). There is also strong epidemiological evidence to suggest that excess body weight is associated with up to a two-fold increased risk of cancer recurrence and death from breast cancer-specific and all-cause mortality (Chan et al, 2014;Ewertz et al, 2011;Kamineni et al, 2013;Protani et al, 2010).…”