Medical Complications of Anorexia Nervosa and Bulimia

Westmoreland, Patricia; Krantz, Mori J.; Mehler, Philip S.

doi:10.1016/j.amjmed.2015.06.031

Cited by 324 publications

(259 citation statements)

References 117 publications

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“…By contrast, bone loss in women with anorexia nervosa reflects a decrease in bone formation and an increase in bone resorption. For both adolescents and adults, decreased BMD can occur relatively rapidly in anorexia nervosa, with changes often apparent after just 1 year of disease 115 . Moreover, the duration of illness is associated with a lower BMD 116 , suggesting that bone loss might continue throughout the course of the illness.…”

Section: Skeletal Integritymentioning

confidence: 99%

The endocrine manifestations of anorexia nervosa: mechanisms and management

2016

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Anorexia nervosa is a psychiatric disorder characterized by altered body image, persistent food restriction and low body weight, and is associated with global endocrine dysregulation in both adolescent girls and women. Dysfunction of the hypothalamic-pituitary axis includes hypogonadotrophic hypogonadism with relative oestrogen and androgen deficiency, growth hormone resistance, hypercortisolaemia, non-thyroidal illness syndrome, hyponatraemia, and hypooxytocinaemia. Serum levels of leptin, an anorexigenic adipokine, are suppressed and levels of ghrelin, an orexigenic gut peptide, are elevated in women with anorexia nervosa; however, levels of peptide YY, an anorexigenic gut peptide, are paradoxically elevated. Although most, but not all, of these endocrine disturbances are adaptive to the low energy state of chronic starvation and reverse with treatment of the eating disorder, many contribute to impaired skeletal integrity, as well as neuropsychiatric comorbidities, in individuals with anorexia nervosa. Although 5–15% of those affected by anorexia nervosa are men, only limited data exists regarding the endocrine impact of the disease in adolescent boys and men. Further research is needed to understand the endocrine determinants of bone loss and neuropsychiatric comorbidities in anorexia nervosa in both women and men, as well as to formulate optimal treatment strategies.

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Section: Skeletal Integritymentioning

confidence: 99%

The endocrine manifestations of anorexia nervosa: mechanisms and management

2016

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“…Bulimia occurs mostly in women (female-to-male ratio of 10:1) 2. Acid-base and electrolyte disturbances are the most dangerous medical complications of bulimia and can result in death from cardiac arrhythmias 3. In bulimia, as in our patient, persistent vomiting induces metabolic alkalosis and hypokalaemia due to loss of gastric acid and potassium in the vomitus.…”

Section: Descriptionmentioning

confidence: 51%

Spontaneous bilateral carpopedal spasm in a bulimic patient

Tachamo¹,

Timilsina²,

Lohani

et al. 2017

BMJ Case Reports

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“…Individuals suffering from anorexia nervosa can also struggle with bulimia, i.e., overeating with purging. The symptomatology of anorexia nervosa is extremely complex with a critical absence of medication [18] and different medical complication, including substance abuse and suicide [19,20]. Food restriction can even alternate with bulimia that differs from binge eating [21].…”

Section: Symptomatology Of Anorexia Nervosamentioning

confidence: 99%

Serotonin 4 Receptors: A Cornerstone in Anorexia Nervosa?

Compan¹

2017

Autism Open Access

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Medical Complications of Anorexia Nervosa and Bulimia

Cited by 324 publications

References 117 publications

The endocrine manifestations of anorexia nervosa: mechanisms and management

The endocrine manifestations of anorexia nervosa: mechanisms and management

Spontaneous bilateral carpopedal spasm in a bulimic patient

Serotonin 4 Receptors: A Cornerstone in Anorexia Nervosa?

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